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Aurothioglucose

Product Name
Aurothioglucose
CAS No.
12192-57-3
Chemical Name
Aurothioglucose
Synonyms
gtg;GGT;GGT 1;brenol;oronol;aurotan;authron;romosol;CS-1197;D22S732
CBNumber
CB4140009
Molecular Formula
C6H11AuO5S
Formula Weight
392.18
MOL File
12192-57-3.mol
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Aurothioglucose Property

Melting point:
>107oC (dec.)
storage temp. 
2-8°C
solubility 
H2O: soluble5mg/mL, clear
form 
powder
color 
white to beige
Merck 
13,887
Stability:
Hygroscopic, Light Sensitive
IARC
3 (Vol. 13, Sup 7) 1987
EPA Substance Registry System
Aurothioglucose (12192-57-3)
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Safety

Hazard Codes 
Xn
Risk Statements 
42/43
Safety Statements 
22-36/37-45
RIDADR 
2811
WGK Germany 
3
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2843300000
Hazardous Substances Data
12192-57-3(Hazardous Substances Data)
Toxicity
LD50 intravenous in chicken: 1gm/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SAB2701966
Product name
Anti-GGT1 antibody produced in rabbit
Packaging
100μL
Price
$496
Updated
2024/03/01
Sigma-Aldrich
Product number
SAB1410523
Product name
Anti-GGT1 antibody produced in rabbit
Purity
purified immunoglobulin, buffered aqueous solution
Packaging
100μg
Price
$524
Updated
2024/03/01
Sigma-Aldrich
Product number
A0606
Product name
Aurothioglucose hydrate
Purity
≥96% (titration)
Packaging
5mg
Price
$201
Updated
2024/03/01
Sigma-Aldrich
Product number
HPA065444
Product name
Anti-GGT1 antibody produced in rabbit
Purity
Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody
Packaging
100μL
Price
$580
Updated
2024/03/01
Sigma-Aldrich
Product number
1045508
Product name
Aurothioglucose hydrate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
100mg
Price
$689
Updated
2024/03/01
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Aurothioglucose Chemical Properties,Usage,Production

Description

Aurothioglucose is highly water soluble, and its aqueous solutions decompose on long standing. It therefore is available as a suspension in sesame oil. Gold content is approximately 50%. Following IM injection, it is highly protein bound (95%), and peak plasma levels are achieved within 2 to 6 hours. Following a single 50-mg dose, the biological half-life ranges from 3 to 27 days, but following successive weekly doses, the half-life increases to 14 to 40 days after the third dose. The therapeutic effect does not correlate with serum plasma gold levels but appears to depend on total accumulated gold. Aurothioglucose is indicated for the adjunctive treatment of adult and juvenile rheumatoid arthritis.

Chemical Properties

yellow crystals,

History

In 1927, aurothioglucose was found to relieve joint pain when used to treat bacterial endocarditis. The area of chrysotherapy had begun. Subsequent investigations led to an extensive study of gold compounds in Great Britain by the Empire Rheumatism Council, which reported in 1961 that sodium aurothiomalate was effective in slowing the development of progressive joint diseases. Both aurothioglucose and sodium aurothiomalate are orally ineffective and are administered by IM injection. In 1985, the first orally effective gold compound for arthritis, auranofin, was introduced in the United States. Several other gold compounds have been evaluated clinically but do not appear to offer advantages in terms of efficacy or toxicity.

Uses

Aurothioglucose hydrate has been used in redox stress survival assay in human cell lines and for inducing obese phenotype in mice.

Uses

To produce obesity in experimental animals.

brand name

Solganal (Schering, USA, Yugoslavia), Aureotan (BYK Gulden, Germany).

Biochem/physiol Actions

Aurothioglucose, a gold compound used clinically to treat rheumatoid arthritis, has recently been found to be a potent PKCiota-Par6 interaction inhibitor, with an IC50 approximately 1 μM. Disruption of this interaction disrupts a rac1 signaling pathway that is required for transformed growth in non-small-cell lung cancer.

Clinical Use

Aurothioglucose is highly water soluble, and its aqueous solutions decompose on long standing. It therefore is available as a suspension in sesame oil. Gold content is approximately 50%. Following IM injection, it is highly protein bound (95%), and peak plasma levels are achieved within 2 to 6 hours. Following a single 50-mg dose, the biological half-life ranges from 3 to 27 days, but following successive weekly doses, the half-life increases to 14 to 40 days after the third dose. The therapeutic effect does not correlate with serum plasma gold levels but appears to depend on total accumulated gold. Aurothioglucose is indicated for the adjunctive treatment of adult and juvenile rheumatoid arthritis.

Safety Profile

Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. A deadly human poison by an unspecified route. An experimental poison by intramuscular route. Moderately toxic by subcutaneous and intravenous routes. Human systemic effects: nausea or vomiting, cholestatic jaundlce, and eye effects. An experimental teratogen. Other experimental reproductive effects. See also GOLD COMPOUNDS. When heated to decomposition it emits very toxic fumes of SOx. Used to treat rheumatoid arthritis.

Synthesis

Synthesis: gold thioglucose is prepared by adding a solution of gold bromide to an aqueous solution of thioglucose that contains sulfur dioxide. After heating, the product is precipitated by the addition of ethanol.

Purification Methods

Purify it by dissolving it in H2O (0.05g in 1mL) and precipitating it by adding EtOH. It yields yellow crystals with a slight mercaptan odour. It decomposes slowly in H2O, and is soluble in propylene glycol but insoluble in EtOH and other common organic solvents. [Caterson & Taylor FEBS Lett 98 351 1979, Cooney et al. Biochem J 259 651 1989.]

Dosage

Aurothioglucose is an antirheumatic used to treat active progressing rheumatoid arthritis and nondisseminated lupus erythematosus. The drug is administered at weekly intervals by intramuscular injection (10 mg, 25 mg, then 50 mg) until 800 mg to 1 g has been given. If improvement takes place, the drug is then administered at levels that balance the urinary excretion of gold. During this maintenance therapy the interval between injections is lengthened to 3 – 4 weeks.

Aurothioglucose Preparation Products And Raw materials

Raw materials

Preparation Products

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Aurothioglucose Suppliers

J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Sinopharm Chemical Reagent Co,Ltd.
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86-21-63210123
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86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
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China
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MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 18112977050
Email
cb6@aikonchem.com
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China
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Sigma-Aldrich
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021-61415566 800-8193336
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orderCN@merckgroup.com
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China
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AN PharmaTech Co Ltd
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sales@anpharma.net
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BOC Sciences
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16314854226
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info@bocsci.com
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United States
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Shandong Xiya Chemical Co., Ltd.
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0539-6365991
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sales@xiyashiji.com
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China
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Beijing Solarbio Science & Tecnology Co., Ltd.
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010-50973186 4009686088
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3193328036@qq.com
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China
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Shandong Ono Chemical Co., Ltd.
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0539-6362799 20)
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0539-6362799(To 20)
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China
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View Lastest Price from Aurothioglucose manufacturers

Career Henan Chemical Co
Product
Aurothioglucose 12192-57-3
Price
US $1.00/KG
Min. Order
1g
Purity
98%
Supply Ability
200kgs
Release date
2020-01-09

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