Aurothioglucose
- Product Name
- Aurothioglucose
- CAS No.
- 12192-57-3
- Chemical Name
- Aurothioglucose
- Synonyms
- gtg;GGT;GGT 1;brenol;oronol;aurotan;authron;romosol;CS-1197;D22S732
- CBNumber
- CB4140009
- Molecular Formula
- C6H11AuO5S
- Formula Weight
- 392.18
- MOL File
- 12192-57-3.mol
Aurothioglucose Property
- Melting point:
- >107oC (dec.)
- storage temp.
- 2-8°C
- solubility
- H2O: soluble5mg/mL, clear
- form
- powder
- color
- white to beige
- Merck
- 13,887
- Stability:
- Hygroscopic, Light Sensitive
- IARC
- 3 (Vol. 13, Sup 7) 1987
- EPA Substance Registry System
- Aurothioglucose (12192-57-3)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 42/43
- Safety Statements
- 22-36/37-45
- RIDADR
- 2811
- WGK Germany
- 3
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 2843300000
- Hazardous Substances Data
- 12192-57-3(Hazardous Substances Data)
- Toxicity
- LD50 intravenous in chicken: 1gm/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SAB2701966
- Product name
- Anti-GGT1 antibody produced in rabbit
- Packaging
- 100μL
- Price
- $496
- Updated
- 2024/03/01
- Product number
- SAB1410523
- Product name
- Anti-GGT1 antibody produced in rabbit
- Purity
- purified immunoglobulin, buffered aqueous solution
- Packaging
- 100μg
- Price
- $524
- Updated
- 2024/03/01
- Product number
- HPA065444
- Product name
- Anti-GGT1 antibody produced in rabbit
- Purity
- Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody
- Packaging
- 100μL
- Price
- $580
- Updated
- 2024/03/01
- Product number
- A0606
- Product name
- Aurothioglucose hydrate
- Purity
- ≥96% (titration)
- Packaging
- 5mg
- Price
- $201
- Updated
- 2024/03/01
- Product number
- 1045508
- Product name
- Aurothioglucose hydrate
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 100mg
- Price
- $689
- Updated
- 2024/03/01
Aurothioglucose Chemical Properties,Usage,Production
Description
Aurothioglucose is highly water soluble, and its aqueous solutions decompose on long standing. It therefore is available as a suspension in sesame oil. Gold content is approximately 50%. Following IM injection, it is highly protein bound (95%), and peak plasma levels are achieved within 2 to 6 hours. Following a single 50-mg dose, the biological half-life ranges from 3 to 27 days, but following successive weekly doses, the half-life increases to 14 to 40 days after the third dose. The therapeutic effect does not correlate with serum plasma gold levels but appears to depend on total accumulated gold. Aurothioglucose is indicated for the adjunctive treatment of adult and juvenile rheumatoid arthritis.
Chemical Properties
yellow crystals,
History
In 1927, aurothioglucose was found to relieve joint pain when used to treat bacterial endocarditis. The area of chrysotherapy had begun. Subsequent investigations led to an extensive study of gold compounds in Great Britain by the Empire Rheumatism Council, which reported in 1961 that sodium aurothiomalate was effective in slowing the development of progressive joint diseases. Both aurothioglucose and sodium aurothiomalate are orally ineffective and are administered by IM injection. In 1985, the first orally effective gold compound for arthritis, auranofin, was introduced in the United States. Several other gold compounds have been evaluated clinically but do not appear to offer advantages in terms of efficacy or toxicity.
Uses
Aurothioglucose hydrate has been used in redox stress survival assay in human cell lines and for inducing obese phenotype in mice.
Uses
To produce obesity in experimental animals.
brand name
Solganal (Schering, USA, Yugoslavia), Aureotan (BYK Gulden, Germany).
Biochem/physiol Actions
Aurothioglucose, a gold compound used clinically to treat rheumatoid arthritis, has recently been found to be a potent PKCiota-Par6 interaction inhibitor, with an IC50 approximately 1 μM. Disruption of this interaction disrupts a rac1 signaling pathway that is required for transformed growth in non-small-cell lung cancer.
Clinical Use
Aurothioglucose is highly water soluble, and its aqueous solutions decompose on long standing. It therefore is available as a suspension in sesame oil. Gold content is approximately 50%. Following IM injection, it is highly protein bound (95%), and peak plasma levels are achieved within 2 to 6 hours. Following a single 50-mg dose, the biological half-life ranges from 3 to 27 days, but following successive weekly doses, the half-life increases to 14 to 40 days after the third dose. The therapeutic effect does not correlate with serum plasma gold levels but appears to depend on total accumulated gold. Aurothioglucose is indicated for the adjunctive treatment of adult and juvenile rheumatoid arthritis.
Safety Profile
Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. A deadly human poison by an unspecified route. An experimental poison by intramuscular route. Moderately toxic by subcutaneous and intravenous routes. Human systemic effects: nausea or vomiting, cholestatic jaundlce, and eye effects. An experimental teratogen. Other experimental reproductive effects. See also GOLD COMPOUNDS. When heated to decomposition it emits very toxic fumes of SOx. Used to treat rheumatoid arthritis.
Synthesis
Synthesis: gold thioglucose is prepared by
adding a solution of gold bromide to an aqueous
solution of thioglucose that contains sulfur dioxide. After heating, the product is precipitated by
the addition of ethanol.
Purification Methods
Purify it by dissolving it in H2O (0.05g in 1mL) and precipitating it by adding EtOH. It yields yellow crystals with a slight mercaptan odour. It decomposes slowly in H2O, and is soluble in propylene glycol but insoluble in EtOH and other common organic solvents. [Caterson & Taylor FEBS Lett 98 351 1979, Cooney et al. Biochem J 259 651 1989.]
Dosage
Aurothioglucose is an antirheumatic used to treat active progressing rheumatoid arthritis and nondisseminated lupus erythematosus. The drug is administered at weekly intervals by intramuscular injection (10 mg, 25 mg, then 50 mg) until 800 mg to 1 g has been given. If improvement takes place, the drug is then administered at levels that balance the urinary excretion of gold. During this maintenance therapy the interval between injections is lengthened to 3 – 4 weeks.
Aurothioglucose Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Aurothioglucose manufacturers
- Product
- Aurothioglucose 12192-57-3
- Price
- US $1.00/KG
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 200kgs
- Release date
- 2020-01-09