Methyl 1-benzylazetidine-2-carboxylate

Product Name: Methyl 1-benzylazetidine-2-carboxylate
CAS No.: 18085-37-5
Chemical Name: Methyl 1-benzylazetidine-2-carboxylate
Synonyms: AKOS MSC-0097;1-Benzyl-2-(methoxycarbonyl)azetidine;METHYL 1-BENZYL-2-AZETIDINECARBOXYLATE;METHYL 1-BENZYLAZETIDINE-2-CARBOXYLATE;1-BENZYL-AZETIDINE-2-CARBOXYLIC ACID METHYL ESTER;Methyl 1-Benzylazetidine-2-carboxylate - [M13115];1-(Phenylmethyl)-2-azetidinecarboxylic acid methyl ester;2-Azetidinecarboxylic acid, 1-(phenylMethyl)-, Methyl ester
CBNumber: CB2341545
Molecular Formula: C12H15NO2
Formula Weight: 205.25
MOL File: 18085-37-5.mol

More

Less

Methyl 1-benzylazetidine-2-carboxylate Property

Boiling point:: 273 °C
Density: 1.153
Flash point:: 101 °C
storage temp.: 2-8°C
pka: 6.42±0.40(Predicted)
Appearance: yellow liquid

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

TRC

Product number: M332190
Product name: Methyl1-Benzylazetidine-2-carboxylate
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Chem-Impex

Product number: 17418
Product name: 1-Benzyl-Azetidine-2-carboxylicacidmethylester,95%(HPLC)
Purity: 95%(HPLC)
Packaging: 250MG
Price: $58.02
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-VG
Product name: Methyl 1-benzylazetidine-2-carboxylate
Purity: 97.0%
Packaging: 250mg
Price: $100
Updated: 2021/12/16

Matrix Scientific

Product number: 119464
Product name: Methyl 1-benzylazetidine-2-carboxylate
Purity: 95+%
Packaging: 1g
Price: $100
Updated: 2021/12/16

Chem-Impex

Product number: 17418
Product name: 1-Benzyl-Azetidine-2-carboxylicacidmethylester,≥95%(HPLC)
Purity: ≥95%(HPLC)
Packaging: 1G
Price: $121.14
Updated: 2021/12/16

More

Less

Methyl 1-benzylazetidine-2-carboxylate Chemical Properties,Usage,Production

Synthesis Reference(s)

The Journal of Organic Chemistry, 46, p. 2991, 1981 DOI: 10.1021/jo00328a001

Synthesis

29547-04-4

100-46-9

18085-37-5

Methyl 2,4-dibromobutyrate (10.01 g, 38.49 mmol, 1.0 eq.) was dissolved in methanol (15 mL) and slowly added dropwise to a stirred solution of triethylamine (11.68 g, 16.01 mL, 115.5 mmol, 3.0 eq.) in methanol (40 mL) at 0 °C. After dropwise addition, stirring was continued for 15 minutes. Subsequently, benzylamine (4.33 g, 4.41 mL, 40.4 mmol, 1.05 eq.) was added dropwise to a methanol (25 mL) solution and stirring was continued for 30 minutes after completion of the dropwise addition. The reaction mixture was then slowly warmed to room temperature and stirred overnight. Upon completion of the reaction, the mixture was concentrated under vacuum, diluted with diethyl ether (100 mL) and filtered to remove insoluble solids. The organic phase was washed with water (200 mL) and the aqueous phase was then back-extracted with ether (3 x 50 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated in vacuum. The crude product was purified by column chromatography (25% ethyl acetate/hexane) to afford methyl 1-benzylazetidine-2-carboxylate as an orange oil (2.02 g, 26% yield). Thin layer chromatography (TLC) Rf value was 0.35 (ethyl acetate:hexane = 1:3). IR spectrum (neat, cm?1): 2953, 2837, 1737, 1442, 1201, 1172. 1H NMR (300 MHz, CDCl3) δ: 7.35-7.17 (m, 5H, ArH), 3.84-3.70 (m, 2H CH2Ph), 3.62 (s, 3H, OCH3), 3.58 (d, 1H, J=12.5 Hz, COCH), 3.35-3.27 (m, 1H, NCH2a), 2.98-2.88 (m, 1H, NCH2b), 2.36 (dt, 1H, J= 8.7, 17.6 Hz, CHCH2a), 2.25-2.13 (m, 1H, CHCH2b).13C NMR (75 MHz, CDCl3) δ: 173.10, 137.08, 129.17, 128.36, 127.32, 64.40, 62.45, 51.83, 50.85, 21.72. 50.85, 21.72. high-resolution mass spectrometry (HRMS, ESI) m/z: 206.1198 ([M+H]+, calculated value 206.1175).

References

[1] Tetrahedron, 2012, vol. 68, # 22, p. 4117 - 4128
[2] Tetrahedron, 1989, vol. 45, # 10, p. 3089 - 3098
[3] Tetrahedron Asymmetry, 1998, vol. 9, # 3, p. 429 - 435
[4] Organic Letters, 2010, vol. 12, # 24, p. 5708 - 5711
[5] European Journal of Medicinal Chemistry, 2017, vol. 127, p. 671 - 690

Methyl 1-benzylazetidine-2-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Methyl 1-benzylazetidine-2-carboxylate Suppliers

Canada 1 China 83 Germany 1 India 1 Russia 1 United Kingdom 2 United States 15 Global 104

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Hangzhou Sage Chemical Co., Ltd.

Tel: +86057186818502 13588463833
Fax: Pls mail us for more information!
Email: info@sagechem.com
Country: China
ProdList: 10266
Advantage: 58

Baiyin Chengze Chemical Technology Co., Ltd.

Tel: +86 943-8535351 13389336721
Fax: +86-943-8535351
Email: sales@chengzechem.com
Country: China
ProdList: 289
Advantage: 58

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: +86-28-85122536 85324413
Fax: +86-28-85326443
Email: market@astatech.cn
Country: China
ProdList: 8026
Advantage: 55

Shanghai ChriChem Co., Ltd.

Tel: 021-54880687
Fax: 021-54880687
Country: China
ProdList: 511
Advantage: 55

Amatek Scientific Co. Ltd.

Tel: 0512-56316828 4008675858
Fax: +86-512-56316826
Email: sales@amateksci.com
Country: China
ProdList: 9874
Advantage: 55

Shanghai Carlow Chemicals Co., Ltd.

Tel: 21-33526724 18930996265
Fax: 37023730
Email: info@carlowchem.com
Country: China
ProdList: 1922
Advantage: 58

Taizhou Tongxin Bio-Tech Co., Ltd

Tel: 0523-86818997 18652728585
Email: sales@allyrise.com
Country: China
ProdList: 2966
Advantage: 60

Wuhan Chemduro Pharm Tech Co. Ltd.

Tel: 18040571231/1402788087
Fax: sales@chemduro.com
Country: China
ProdList: 1973
Advantage: 58

More

Less

View Lastest Price from Methyl 1-benzylazetidine-2-carboxylate manufacturers

Career Henan Chemica Co

Product: Methyl 1-benzylazetidine-2-carboxylate 18085-37-5
Price: US $0.37/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg/100kg
Release date: 2020-11-09

18085-37-5, Methyl 1-benzylazetidine-2-carboxylateRelated Search:

(S)-(-)-2-Azetidinecarboxylic acid ISOBUTANE Benzyl nicotinate Benzyl alcohol Methyl salicylate Benzyltriethylammonium chloride Benzyl chloride Kresoxim-methyl 1,2,3,4-Butanetetracarboxylic acid METSULFURON METHYL Methyl acrylate Benzyl benzoate n-Butane Benzyl bromide Methylparaben 1-Bromo-2-methylpropane RESMETHRIN Thiophanate-methyl

METHYL 1-BENZYLAZETIDINE-2-CARBOXYLATE

METHYL 1-BENZYL-2-AZETIDINECARBOXYLATE

1-BENZYL-AZETIDINE-2-CARBOXYLIC ACID METHYL ESTER

AKOS MSC-0097

1-Benzyl-2-(methoxycarbonyl)azetidine

1-(Phenylmethyl)-2-azetidinecarboxylic acid methyl ester

2-Azetidinecarboxylic acid, 1-(phenylMethyl)-, Methyl ester

Methyl 1-Benzylazetidine-2-carboxylate - [M13115]

18085-37-5

Amines and Anilines

Amino Acids and Derivatives