4-Hydroxy-2,6-dimethylpyridine

Product Name: 4-Hydroxy-2,6-dimethylpyridine
CAS No.: 13603-44-6
Chemical Name: 4-Hydroxy-2,6-dimethylpyridine
Synonyms: 2,6-Dimethyl-4-pyridinol;2,6-DIMETHYL-PYRIDIN-4-OL;2,6-Dimethylpyridine-4-ol;4-PYRIDINOL, 2,6-DIMETHYL-;4-HYDROXY-2,6-DIMETHYLPYRIDINE;2,6-DIMETHYL-4-HYDROXYPYRIDINE;2,6-Dimethyl-4-hydroxypyridine>2,6-Dimethyl-4-hydroxypyridine 98%;2,6- two methyl -4- hydroxypyridine;2,6-Dimethyl-4-hydroxypyridine ,98%
CBNumber: CB2345053
Molecular Formula: C7H9NO
Formula Weight: 123.15
MOL File: 13603-44-6.mol

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4-Hydroxy-2,6-dimethylpyridine Property

Melting point:: 230-232°C
Boiling point:: 351 °C
Density: 1,053g/cm
refractive index: 1,501-1,503
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly, Heated), Methanol (Slightly)
form: Solid
pka: 5.49±0.23(Predicted)
color: White to Off-White
InChI: InChI=1S/C7H9NO/c1-5-3-7(9)4-6(2)8-5/h3-4H,1-2H3,(H,8,9)
InChIKey: PRAFLUMTYHBEHE-UHFFFAOYSA-N
SMILES: C1(C)=NC(C)=CC(O)=C1
LogP: 0.190 (est)
CAS DataBase Reference: 13603-44-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-36/37/39
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D3638
Product name: 2,6-Dimethyl-4-hydroxypyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $40
Updated: 2025/07/31

TCI Chemical

Product number: D3638
Product name: 2,6-Dimethyl-4-hydroxypyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $198
Updated: 2025/07/31

TRC

Product number: D473270
Product name: 2,6-Dimethyl-4-hydroxypyridine
Packaging: 2.5g
Price: $110
Updated: 2021/12/16

TRC

Product number: D473270
Product name: 2,6-Dimethyl-4-hydroxypyridine
Packaging: 25g
Price: $300
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK190019
Product name: 2,6-Dimethyl-4-hydroxypyridine
Purity: 98%
Packaging: 5g
Price: $310
Updated: 2021/12/16

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4-Hydroxy-2,6-dimethylpyridine Chemical Properties,Usage,Production

Chemical Properties

Yellow to Brown Cryst

Uses

2,6-Dimethyl-4-hydroxypyridine is a useful synthetic intermediate. It is used in the synthesis of disubstituted pyridinyl-aminohydantoins as selective human BACE1 inhibitors.

Synthesis

520-45-6

13603-44-6

The general procedure for the synthesis of 2,6-dimethyl-4-hydroxypyridine from dehydroacetic acid was as follows: five different batches of dehydroacetic acid (1.5 g, 8.92 mmol) were suspended in concentrated ammonia (4 mL) and placed in a microwave reactor (Discover system, 150 W, CEM Corporation, Matthews, North Carolina, USA) and microwave irradiated at 120°C for 20 min. Upon completion of the reaction, the reaction mixture was cooled and all batches were combined and subsequently evaporated to dryness to afford the target product 2,6-dimethyl-4-hydroxypyridine. The mass of the product was 5.91 g (108% yield), which was analyzed by LC/MS showing a purity of 73%. Unreacted dehydroacetic acid was present as a residual mass balance.The LC/MS retention time was 0.67 min and the mass spectrum (ES+) showed m/z 168 (M + CH3CN + H).

References

[1] Patent: WO2008/57497, 2008, A2. Location in patent: Page/Page column 252-253
[2] Patent: WO2008/57469, 2008, A1. Location in patent: Page/Page column 252-253
[3] Patent: WO2008/57468, 2008, A1. Location in patent: Page/Page column 252-253
[4] Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1988, vol. 42, # 6, p. 373 - 377
[5] Chemische Berichte, 1887, vol. 20, p. 159

4-Hydroxy-2,6-dimethylpyridine Preparation Products And Raw materials

Raw materials

Sodium nitrite 2,6-DIMETHYL-PYRIDIN-4-YLAMINE Sulfuric acid

Preparation Products

2,6-DIMETHYL-PYRIDIN-4-YLAMINE

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4-Hydroxy-2,6-dimethylpyridine Suppliers

Americas 1 Canada 2 China 160 Europe 4 France 1 Germany 4 India 2 Japan 2 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 10 United States 34 USA 1 Global 224

Changzhou Yanji Biotechnology Co., Ltd.

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TCI (Shanghai) Development Co., Ltd.

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Energy Chemical

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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

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Changzhou Huanling Chemical Co., Ltd.

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Pure Chemistry Scientific Inc.

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View Lastest Price from 4-Hydroxy-2,6-dimethylpyridine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Hydroxy-2,6-dimethylpyridine 13603-44-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-12

Honest Joy Holdings Limited

Product: 2,6-Dimethyl-4-hydroxypyridine 13603-44-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.9%
Supply Ability: 100 tons
Release date: 2022-01-26

Dideu Industries Group Limited

Product: 4-Hydroxy-2,6-dimethylpyridine 13603-44-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-09-24

13603-44-6, 4-Hydroxy-2,6-dimethylpyridineRelated Search:

4-Hydroxy-2,6-dimethylpyridine 2,6-DIMETHYL-3-HYDROXYPYRIDINE Pirenoxine Clopidol Chelidamic acid 5-Bromo-3-cyano-2-hydroxy-4,6-dimethylpyridine, 98% 3-HYDROXY-2,5-DIMETHYLPYRIDINE-4-CARBOXALDEHYDE 2-Hydroxy-4,6-dimethylpyridine 5,7-DIMETHYLPYRIDO[2,3-D]PYRIMIDIN-4(3H)-ONE 2-HYDROXY-5,6-DIMETHYLPYRIDINE-3-CARBONITRILE 2-Hydroxy-4,6-dimethylpyridine-3-carbonitrile ,98%,2-hydroxy-4,6-dimethylpyridine-3-carbonitrile,3-Cyano-2-hydroxy-4,6-dimethylpyridine, 98% 2,6-Lutidine 4'-METHOXY-2,2':6',2''-TERPYRIDINE 4'-HYDROXY-2,2':6',2''-TERPYRIDINE COLLISMYCIN A 4-[2,6-BIS(TRIFLUOROMETHYL)PYRIDIN-4-YLOXY]ANILINE 5,8-DIHYDRO-4,6-DIHYDROXY-5,8-DIOXO-2-QUINOLINECARBOXYLIC ACID 4'-ETHOXY-2,2':6',2''-TERPYRIDINE

2,6-DIMETHYL-PYRIDIN-4-OL

2,6-DIMETHYL-4-HYDROXYPYRIDINE

2,6-Dimethyl-4-hydroxypyridine 98%

2,6-Dimethyl-4-pyridinol

2,6-Dimethyl-4-hydroxypyridine ,98%

2,6-Dimethylpyridine-4-ol

2,6-Dimethylpyridin-4-ol, 4-Hydroxy-2,6-lutidine

4-HYDROXY-2,6-DIMETHYLPYRIDINE

4-PYRIDINOL, 2,6-DIMETHYL-

2,6- two methyl -4- hydroxypyridine

2,6-Dimethyl-4-hydroxypyridine&gt

4-Hydroxy-2,6-dimethylpyridine ISO 9001：2015 REACH

13603-44-6

13603-44-5

Heterocycle-Pyridine series

Heterocyclic Building Blocks

pharmacetical

Pyridine

Pyridines derivates

Heterocyclic Compounds

Pyridines