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4-Hydroxy-2,6-dimethylpyridine

Product Name
4-Hydroxy-2,6-dimethylpyridine
CAS No.
13603-44-6
Chemical Name
4-Hydroxy-2,6-dimethylpyridine
Synonyms
2,6-Dimethyl-4-pyridinol;2,6-DIMETHYL-PYRIDIN-4-OL;2,6-Dimethylpyridine-4-ol;4-PYRIDINOL, 2,6-DIMETHYL-;4-HYDROXY-2,6-DIMETHYLPYRIDINE;2,6-DIMETHYL-4-HYDROXYPYRIDINE;2,6-Dimethyl-4-hydroxypyridine>2,6-Dimethyl-4-hydroxypyridine 98%;2,6- two methyl -4- hydroxypyridine;2,6-Dimethyl-4-hydroxypyridine ,98%
CBNumber
CB2345053
Molecular Formula
C7H9NO
Formula Weight
123.15
MOL File
13603-44-6.mol
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4-Hydroxy-2,6-dimethylpyridine Property

Melting point:
230-232°C
Boiling point:
351 °C
Density 
1,053g/cm
refractive index 
1,501-1,503
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly, Heated), Methanol (Slightly)
form 
Solid
pka
5.49±0.23(Predicted)
color 
White to Off-White
InChI
InChI=1S/C7H9NO/c1-5-3-7(9)4-6(2)8-5/h3-4H,1-2H3,(H,8,9)
InChIKey
PRAFLUMTYHBEHE-UHFFFAOYSA-N
SMILES
C1(C)=NC(C)=CC(O)=C1
LogP
0.190 (est)
CAS DataBase Reference
13603-44-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-36/37/39
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D3638
Product name
2,6-Dimethyl-4-hydroxypyridine
Purity
>98.0%(GC)
Packaging
1g
Price
$40
Updated
2025/07/31
TCI Chemical
Product number
D3638
Product name
2,6-Dimethyl-4-hydroxypyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$198
Updated
2025/07/31
TRC
Product number
D473270
Product name
2,6-Dimethyl-4-hydroxypyridine
Packaging
2.5g
Price
$110
Updated
2021/12/16
TRC
Product number
D473270
Product name
2,6-Dimethyl-4-hydroxypyridine
Packaging
25g
Price
$300
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK190019
Product name
2,6-Dimethyl-4-hydroxypyridine
Purity
98%
Packaging
5g
Price
$310
Updated
2021/12/16
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4-Hydroxy-2,6-dimethylpyridine Chemical Properties,Usage,Production

Chemical Properties

Yellow to Brown Cryst

Uses

2,6-Dimethyl-4-hydroxypyridine is a useful synthetic intermediate. It is used in the synthesis of disubstituted pyridinyl-aminohydantoins as selective human BACE1 inhibitors.

Synthesis

520-45-6

13603-44-6

The general procedure for the synthesis of 2,6-dimethyl-4-hydroxypyridine from dehydroacetic acid was as follows: five different batches of dehydroacetic acid (1.5 g, 8.92 mmol) were suspended in concentrated ammonia (4 mL) and placed in a microwave reactor (Discover system, 150 W, CEM Corporation, Matthews, North Carolina, USA) and microwave irradiated at 120°C for 20 min. Upon completion of the reaction, the reaction mixture was cooled and all batches were combined and subsequently evaporated to dryness to afford the target product 2,6-dimethyl-4-hydroxypyridine. The mass of the product was 5.91 g (108% yield), which was analyzed by LC/MS showing a purity of 73%. Unreacted dehydroacetic acid was present as a residual mass balance.The LC/MS retention time was 0.67 min and the mass spectrum (ES+) showed m/z 168 (M + CH3CN + H).

References

[1] Patent: WO2008/57497, 2008, A2. Location in patent: Page/Page column 252-253
[2] Patent: WO2008/57469, 2008, A1. Location in patent: Page/Page column 252-253
[3] Patent: WO2008/57468, 2008, A1. Location in patent: Page/Page column 252-253
[4] Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1988, vol. 42, # 6, p. 373 - 377
[5] Chemische Berichte, 1887, vol. 20, p. 159

4-Hydroxy-2,6-dimethylpyridine Preparation Products And Raw materials

Raw materials

Sodium nitrite 2,6-DIMETHYL-PYRIDIN-4-YLAMINE Sulfuric acid

Preparation Products

2,6-DIMETHYL-PYRIDIN-4-YLAMINE
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4-Hydroxy-2,6-dimethylpyridine Suppliers

Americas 1 Canada 2 China 160 Europe 4 France 1 Germany 4 India 2 Japan 2 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 10 United States 34 USA 1 Global 224
Dishman USA, Inc.
Tel
--
Fax
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Country
Canada
ProdList
743
Advantage
75
AB Chemicals Inc.
Tel
--
Fax
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Email
sales@abcheminc.com
Country
Canada
ProdList
1128
Advantage
47
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View Lastest Price from 4-Hydroxy-2,6-dimethylpyridine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Hydroxy-2,6-dimethylpyridine 13603-44-6
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-12
Honest Joy Holdings Limited
Product
2,6-Dimethyl-4-hydroxypyridine 13603-44-6
Price
US $0.00/KG
Min. Order
1KG
Purity
98.9%
Supply Ability
100 tons
Release date
2022-01-26
Dideu Industries Group Limited
Product
4-Hydroxy-2,6-dimethylpyridine 13603-44-6
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-09-24

13603-44-6, 4-Hydroxy-2,6-dimethylpyridineRelated Search:

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  • 2,6-DIMETHYL-PYRIDIN-4-OL
  • 2,6-DIMETHYL-4-HYDROXYPYRIDINE
  • 2,6-Dimethyl-4-hydroxypyridine 98%
  • 2,6-Dimethyl-4-pyridinol
  • 2,6-Dimethyl-4-hydroxypyridine ,98%
  • 2,6-Dimethylpyridine-4-ol
  • 2,6-Dimethylpyridin-4-ol, 4-Hydroxy-2,6-lutidine
  • 4-HYDROXY-2,6-DIMETHYLPYRIDINE
  • 4-PYRIDINOL, 2,6-DIMETHYL-
  • 2,6- two methyl -4- hydroxypyridine
  • 2,6-Dimethyl-4-hydroxypyridine&gt
  • 4-Hydroxy-2,6-dimethylpyridine ISO 9001：2015 REACH
  • 13603-44-6
  • 13603-44-5
  • Heterocycle-Pyridine series
  • Heterocyclic Building Blocks
  • pharmacetical
  • Pyridine
  • Pyridines derivates
  • Heterocyclic Compounds
  • Pyridines