(R)-(+)-WARFARIN
- Product Name
- (R)-(+)-WARFARIN
- CAS No.
- 5543-58-8
- Chemical Name
- (R)-(+)-WARFARIN
- Synonyms
- (R)-WARFARIN;Dextrowarfarin;(R)-(+)-WARFARIN;Warfarin R-Isomer;Warfarin Impurity 16;Warfarin Impurity 16(Warfarin R-Isomer);r-(+)-3-acetonybenzyl)-4-hydroxycoumarin;R-(+)-3-(ACETONYLBENZYL)-4-HYDROXYCOUMARIN;(S)-3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin;(+)-3-[(R)-α-Acetonylbenzyl]-4-hydroxycoumarin
- CBNumber
- CB2351124
- Molecular Formula
- C19H16O4
- Formula Weight
- 308.33
- MOL File
- 5543-58-8.mol
(R)-(+)-WARFARIN Property
- Melting point:
- ≥170 °C
- Boiling point:
- 515.2±50.0 °C(Predicted)
- Density
- 1.307±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMF: soluble
- pka
- 4.50±1.00(Predicted)
- form
- A crystalline solid
- color
- white to pale yellow
Safety
- Hazard Codes
- T
- Risk Statements
- 61-48/25-52/53
- Safety Statements
- 53-45-61
- RIDADR
- UN 2811 6.1/PG 1
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H372Causes damage to organs through prolonged or repeated exposure
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- UC213
- Product name
- (R)-(+)-Warfarin
- Purity
- ≥97% (HPLC)
- Packaging
- 10mg
- Price
- $1520
- Updated
- 2022/05/15
- Product number
- 13526
- Product name
- (+)-Warfarin
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $77
- Updated
- 2024/03/01
- Product number
- 13526
- Product name
- (+)-Warfarin
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $211
- Updated
- 2024/03/01
- Product number
- 13526
- Product name
- (+)-Warfarin
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $383
- Updated
- 2024/03/01
- Product number
- 13526
- Product name
- (+)-Warfarin
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $861
- Updated
- 2024/03/01
(R)-(+)-WARFARIN Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
(R)-(+)-warfarin has been used to investigate whether enantiomers of warfarin stereoselectively interact with pregnane X nuclear receptor (PXR) to upregulate main drug/xenobiotic-metabolizing enzymes cytochrome P450 3A4 (CYP3A4) and cytochrome P450 2C9 (CYP2C9). It has also been used in HepG2 cells to study protein profiles
Uses
The R-(+)-form of Warfarin (W498500). Coumarin anticoagulant.
Definition
ChEBI: (R)-warfarin is a 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one that has (R)-configuration (the racemate is warfarin, an anticoagulant drug and rodenticide). It is a conjugate acid of a (R)-warfarin(1-). It is an enantiomer of a (S)-warfarin.
General Description
The chiral carbon at position 9 produces two enantiomers, R- and S-warfarin. Commercially available warfarin (Coumadin or Jantoven) is a racemic mixture of S- and R-enantiomers.
Biochem/physiol Actions
Warfarin acts as a vitamin K antagonist. It is widely used to treat thromboembolic disorders. (R)-warfarin interacts with pregnane X receptor (PXR) and induces cytochrome P450 3A4 (CYP3A4) and CYP2C9 mRNAs expression in primary human hepatocyte cultures.
(R)-(+)-WARFARIN Preparation Products And Raw materials
Raw materials
Preparation Products
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