(S)-(-)-WARFARIN

Product Name: (S)-(-)-WARFARIN
CAS No.: 5543-57-7
Chemical Name: (S)-(-)-WARFARIN
Synonyms: Warfarin,R-;(S)-WARFARIN;(S)-(-)-WARFARIN;Warfarin S-Isomer;Warfarin Impurity 17;Warfarin Impurity 17（Warfarin S-Isomer）;s-(-)-3-acetonybenzyl)-4-hydroxycoumarin;S-(-)-3-(ACETONYLBENZYL)-4-HYDROXYCOUMARIN;Warfarin sodium Impurity 23 ((S)-Warfarin);2-hydroxy-3-(3-keto-1-phenyl-butyl)chromone
CBNumber: CB7267099
Molecular Formula: C19H16O4
Formula Weight: 308.33
MOL File: 5543-57-7.mol

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(S)-(-)-WARFARIN Property

Melting point:: ≥170 °C
storage temp.: 2-8°C
solubility: DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 5 mg/ml
form: A crystalline solid
color: white to pale yellow
CAS DataBase Reference: 5543-57-7(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 61-48/25-52/53
Safety Statements: 53-45-61
RIDADR: UN 2811 6.1/PG 1
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H372Causes damage to organs through prolonged or repeated exposure

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: UC214
Product name: (S)-(?)-Warfarin
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $918
Updated: 2024/03/01

Sigma-Aldrich

Product number: UC214
Product name: (S)-(?)-Warfarin
Purity: ≥97% (HPLC)
Packaging: 10mg
Price: $1660
Updated: 2024/03/01

Cayman Chemical

Product number: 13531
Product name: (-)-Warfarin
Purity: ≥98%
Packaging: 1mg
Price: $74
Updated: 2024/03/01

Cayman Chemical

Product number: 13531
Product name: (-)-Warfarin
Purity: ≥98%
Packaging: 5mg
Price: $241
Updated: 2024/03/01

Cayman Chemical

Product number: 13531
Product name: (-)-Warfarin
Purity: ≥98%
Packaging: 10mg
Price: $444
Updated: 2024/03/01

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(S)-(-)-WARFARIN Chemical Properties,Usage,Production

Description

(–)-Warfarin is a component of (±)-warfarin . It is an anticoagulant that interferes with interconversion of vitamin K and vitamin K epoxide and the role of vitamin K in carboxylation of several clotting cascade proteins, inhibiting the initiation of clotting. In vivo, (–)-warfarin slows formation of the prothrombin complex and exhibits 6.6-fold more potent anticoagulant activity than (+)-warfarin in rats. (–)-Warfarin is primarily metabolized by the cytochrome P450 (CYP) isoform CYP2C9 and genetic polymorphisms in this enyzme, as well as other compounds metabolized by CYP2C9, increase the potential for catastrophic bleeding complications. Formulations containing warfarin have been used to treat and prevent blood clots in atrial fibrillation, heart valve replacement, venous thrombosis, and pulmonary embolism.

Chemical Properties

White Solid

Uses

The S-(-)-form of Warfarin (W498500). Coumarin anticoagulant.

Uses

(S)-(?)-Warfarin has been used in cell cultures.

Definition

ChEBI: (S)-warfarin is a 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one that has (S)-configuration (the racemate is warfarin, an anticoagulant drug and rodenticide). It is a conjugate acid of a (S)-warfarin(1-). It is an enantiomer of a (R)-warfarin.

General Description

Warfarin is an antagonist of vitamin K. It is an oral coumarin anticoagulant.

Biochem/physiol Actions

Warfarin is used to regulate and inhibit thromboembolic disorders. The CYP2C9 (cytochrome P450 family 2 subfamily C member 9)?protein plays a major role in the inactivation of potent S-warfarin.

(S)-(-)-WARFARIN Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-(-)-WARFARIN Suppliers

Canada 2 China 46 France 1 Germany 2 India 3 Japan 1 Switzerland 1 United Kingdom 5 United States 11 Global 72

J & K SCIENTIFIC LTD.

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Sigma-Aldrich

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Shenzhen Regent Biochemical Technology Co., Ltd.

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Shanghai Zhen Li Biological Technology Co., Ltd

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View Lastest Price from (S)-(-)-WARFARIN manufacturers

Career Henan Chemica Co

Product: (S)-(-)-WARFARIN 5543-57-7
Price: US $0.37/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg/100kg
Release date: 2020-11-09

5543-57-7, (S)-(-)-WARFARINRelated Search:

Warfarin 4-Hydroxycoumarin 4,4'-(Disulfanediyl)bis(2,6-di-tert-butylphenol) (S)-8-Hydroxy Warfarin 6-HYDROXYWARFARIN (R)-6-Hydroxy Warfarin 3-(o-Hydroxyphenyl)-5-phenyl-2-cyclohexen-1-one Benzalacetone 3-[α-(2-Hydroxypropyl)benzyl]-4-hydroxycouMarin (R)-7-Hydroxy Warfarin 7-HYDROXYWARFARIN (S)-6-Hydroxy Warfarin Warfarin Impurity 1 8-HYDROXYWARFARIN 2,6-Di-tert-butyl-4-mercaptophenol 7-HYDROXYWARFARIN (R)-(+)-WARFARIN,(R)-WARFARIN (R)-8-HYDROXY WARFARIN

Coumarin, 3-(a-acetonylbenzyl)-4-hydroxy-, (S)-(-)- (8CI)

4-Hydroxy-3-(3-oxo-1-phenyl-butyl)-chromen-2-one

S-(-)-3-Acetonybenzyl)-4-hydroxycoumarin, S-(-)-4-Hydroxy-3-(3-oxo-1-phenybutyl)-2H-1-benzopyran-2-one

(-)-3-[(S)-1-Phenyl-3-oxobutyl]-4-hydroxycoumarin

(-)-3-[(S)-α-Acetonylbenzyl]-4-hydroxycoumarin

(-)-4-Hydroxy-3-[(S)-3-oxo-1-phenylbutyl]-2H-1-benzopyran-2-one

2-hydroxy-3-(3-keto-1-phenyl-butyl)chromone

2-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-4-one

4-Hydroxy-3-[(1S)-3-oxo-1-phenylbutyl]-2H-1-benzopyran-2-one

(S)-(-)-WARFARIN

(S)-WARFARIN

(S)-(+)-4-HYDROXY-3-(3-OXO-1-PHENYBUTYL)-2H-1-BENZOPYRAN-2-ONE

S-(-)-4-HYDROXY-3-(3-OXO-1-PHENYBUTYL)-2H-1-BENZOPYRAN-2-ONE

(S)-(+)-4-HYDROXY-3-(3-OXO-1-PHENYLBUTYL)-2H-1-BENZOPYRAN-2-ONE

S-(-)-3-(ACETONYLBENZYL)-4-HYDROXYCOUMARIN

(S)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone

Warfarin,R-

(S)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one

4-HYDROXY-3-((S)-3-OXO-1-PHENYL-BUTYL)-CHROMEN-2-ONE

s-(-)-3-acetonybenzyl)-4-hydroxycoumarin

2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-, (S)-

2H-1-Benzopyran-2-one, 4-hydroxy-3-[(1S)-3-oxo-1-phenylbutyl]- (9CI)

Warfarin S-Isomer

Warfarin Impurity 17（Warfarin S-Isomer）

Warfarin Impurity 17

S-(-)-WarfarinQ: What is S-(-)-Warfarin Q: What is the CAS Number of S-(-)-Warfarin Q: What is the storage condition of S-(-)-Warfarin Q: What are the applications of S-(-)-Warfarin

Warfarin sodium Impurity 23 ((S)-Warfarin)

5543-57-7

C19H16O4

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Heterocycles