(S)-(-)-WARFARIN

Product Name: (S)-(-)-WARFARIN
CAS No.: 5543-57-7
Chemical Name: (S)-(-)-WARFARIN
Synonyms: Warfarin,R-;(S)-WARFARIN;(S)-(-)-WARFARIN;Warfarin S-Isomer;Warfarin Impurity 17;Warfarin Impurity 17（Warfarin S-Isomer）;s-(-)-3-acetonybenzyl)-4-hydroxycoumarin;S-(-)-3-(ACETONYLBENZYL)-4-HYDROXYCOUMARIN;Warfarin sodium Impurity 23 ((S)-Warfarin);2-hydroxy-3-(3-keto-1-phenyl-butyl)chromone
CBNumber: CB7267099
Molecular Formula: C19H16O4
Formula Weight: 308.33
MOL File: 5543-57-7.mol

More

Less

(S)-(-)-WARFARIN Property

Melting point:: ≥170 °C
storage temp.: 2-8°C
solubility: DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 5 mg/ml
form: A crystalline solid
color: white to pale yellow
CAS DataBase Reference: 5543-57-7(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: T
Risk Statements: 61-48/25-52/53
Safety Statements: 53-45-61
RIDADR: UN 2811 6.1/PG 1
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H372Causes damage to organs through prolonged or repeated exposure

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: UC214
Product name: (S)-(?)-Warfarin
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $918
Updated: 2024/03/01

Sigma-Aldrich

Product number: UC214
Product name: (S)-(?)-Warfarin
Purity: ≥97% (HPLC)
Packaging: 10mg
Price: $1660
Updated: 2024/03/01

Cayman Chemical

Product number: 13531
Product name: (-)-Warfarin
Purity: ≥98%
Packaging: 1mg
Price: $74
Updated: 2024/03/01

Cayman Chemical

Product number: 13531
Product name: (-)-Warfarin
Purity: ≥98%
Packaging: 5mg
Price: $241
Updated: 2024/03/01

Cayman Chemical

Product number: 13531
Product name: (-)-Warfarin
Purity: ≥98%
Packaging: 10mg
Price: $444
Updated: 2024/03/01

More

Less

(S)-(-)-WARFARIN Chemical Properties,Usage,Production

Description

(–)-Warfarin is a component of (±)-warfarin . It is an anticoagulant that interferes with interconversion of vitamin K and vitamin K epoxide and the role of vitamin K in carboxylation of several clotting cascade proteins, inhibiting the initiation of clotting. In vivo, (–)-warfarin slows formation of the prothrombin complex and exhibits 6.6-fold more potent anticoagulant activity than (+)-warfarin in rats. (–)-Warfarin is primarily metabolized by the cytochrome P450 (CYP) isoform CYP2C9 and genetic polymorphisms in this enyzme, as well as other compounds metabolized by CYP2C9, increase the potential for catastrophic bleeding complications. Formulations containing warfarin have been used to treat and prevent blood clots in atrial fibrillation, heart valve replacement, venous thrombosis, and pulmonary embolism.

Chemical Properties

White Solid

Uses

The S-(-)-form of Warfarin (W498500). Coumarin anticoagulant.

Uses

(S)-(?)-Warfarin has been used in cell cultures.

Definition

ChEBI: (S)-warfarin is a 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one that has (S)-configuration (the racemate is warfarin, an anticoagulant drug and rodenticide). It is a conjugate acid of a (S)-warfarin(1-). It is an enantiomer of a (R)-warfarin.

General Description

Warfarin is an antagonist of vitamin K. It is an oral coumarin anticoagulant.

Biochem/physiol Actions

Warfarin is used to regulate and inhibit thromboembolic disorders. The CYP2C9 (cytochrome P450 family 2 subfamily C member 9)?protein plays a major role in the inactivation of potent S-warfarin.

(S)-(-)-WARFARIN Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

(S)-(-)-WARFARIN Suppliers

Canada 2 China 42 France 1 Germany 2 India 3 Japan 1 Switzerland 1 United Kingdom 5 United States 11 Global 68

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94838
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
Fax: +86-21-50462321
Email: han_yajun@dctc.daicel.com
Country: China
ProdList: 6818
Advantage: 65

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9911
Advantage: 50

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Nanjing XiZe Biotechnology CO., Ltd.

Tel: 025-58362220 15250997978
Fax: 025-58362220
Email: 1511893459@qq.com
Country: China
ProdList: 7715
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Shenzhen Regent Biochemical Technology Co., Ltd.

Tel: 0755-0755-85201366 18938635012
Fax: 0755-85201366
Email: sales@regentsciences.com
Country: China
ProdList: 9288
Advantage: 58

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 1979
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 13028896684
Email: sales@rrkchem.com
Country: China
ProdList: 55791
Advantage: 58

More

Less

View Lastest Price from (S)-(-)-WARFARIN manufacturers

Career Henan Chemica Co

Product: (S)-(-)-WARFARIN 5543-57-7
Price: US $0.37/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg/100kg
Release date: 2020-11-09

5543-57-7, (S)-(-)-WARFARINRelated Search:

Warfarin 4-Hydroxycoumarin 4,4'-(Disulfanediyl)bis(2,6-di-tert-butylphenol) (S)-8-Hydroxy Warfarin 6-HYDROXYWARFARIN (R)-6-Hydroxy Warfarin 3-(o-Hydroxyphenyl)-5-phenyl-2-cyclohexen-1-one Benzalacetone 3-[α-(2-Hydroxypropyl)benzyl]-4-hydroxycouMarin (R)-7-Hydroxy Warfarin 7-HYDROXYWARFARIN (S)-6-Hydroxy Warfarin Warfarin Impurity 1 8-HYDROXYWARFARIN 2,6-Di-tert-butyl-4-mercaptophenol 7-HYDROXYWARFARIN (R)-(+)-WARFARIN,(R)-WARFARIN (R)-8-HYDROXY WARFARIN

Coumarin, 3-(a-acetonylbenzyl)-4-hydroxy-, (S)-(-)- (8CI)

4-Hydroxy-3-(3-oxo-1-phenyl-butyl)-chromen-2-one

S-(-)-3-Acetonybenzyl)-4-hydroxycoumarin, S-(-)-4-Hydroxy-3-(3-oxo-1-phenybutyl)-2H-1-benzopyran-2-one

(-)-3-[(S)-1-Phenyl-3-oxobutyl]-4-hydroxycoumarin

(-)-3-[(S)-α-Acetonylbenzyl]-4-hydroxycoumarin

(-)-4-Hydroxy-3-[(S)-3-oxo-1-phenylbutyl]-2H-1-benzopyran-2-one

2-hydroxy-3-(3-keto-1-phenyl-butyl)chromone

2-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-4-one

4-Hydroxy-3-[(1S)-3-oxo-1-phenylbutyl]-2H-1-benzopyran-2-one

(S)-(-)-WARFARIN

(S)-WARFARIN

(S)-(+)-4-HYDROXY-3-(3-OXO-1-PHENYBUTYL)-2H-1-BENZOPYRAN-2-ONE

S-(-)-4-HYDROXY-3-(3-OXO-1-PHENYBUTYL)-2H-1-BENZOPYRAN-2-ONE

(S)-(+)-4-HYDROXY-3-(3-OXO-1-PHENYLBUTYL)-2H-1-BENZOPYRAN-2-ONE

S-(-)-3-(ACETONYLBENZYL)-4-HYDROXYCOUMARIN

(S)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone

Warfarin,R-

(S)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one

4-HYDROXY-3-((S)-3-OXO-1-PHENYL-BUTYL)-CHROMEN-2-ONE

s-(-)-3-acetonybenzyl)-4-hydroxycoumarin

2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-, (S)-

2H-1-Benzopyran-2-one, 4-hydroxy-3-[(1S)-3-oxo-1-phenylbutyl]- (9CI)

Warfarin S-Isomer

Warfarin Impurity 17（Warfarin S-Isomer）

Warfarin Impurity 17

S-(-)-WarfarinQ: What is S-(-)-Warfarin Q: What is the CAS Number of S-(-)-Warfarin Q: What is the storage condition of S-(-)-Warfarin Q: What are the applications of S-(-)-Warfarin

Warfarin sodium Impurity 23 ((S)-Warfarin)

5543-57-7

C19H16O4

Intermediates & Fine Chemicals

Pharmaceuticals

Aromatics

Chiral Reagents

Heterocycles