Hydantoin

ChemicalBook > CAS DataBase List > Hydantoin

Product Name: Hydantoin
CAS No.: 461-72-3
Chemical Name: Hydantoin
Synonyms: Imidazolidine-2,4-dione;2,4-IMIDAZOLIDINEDIONE;Maine;NSC 922;NSC 9226;HYDANTOIN;GLYCOLYLUREA;Hydantoin>Hydantoin,99%;glycollylurea
CBNumber: CB2352752
Molecular Formula: C3H4N2O2
Formula Weight: 100.08
MOL File: 461-72-3.mol

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Hydantoin Property

Melting point:: 218-220 °C (lit.)
Boiling point:: 187.47°C (rough estimate)
Density: 1.4457 (rough estimate)
vapor pressure: 0Pa at 25℃
refractive index: 1.5110 (estimate)
storage temp.: Store below +30°C.
solubility: SLIGHTLY SOLUBLE
pka: pKa 9.1 (Uncertain)
form: Fine Powder
color: White to light yellow
Water Solubility: SLIGHTLY SOLUBLE
Merck: 14,4760
BRN: 110598
LogP: -1.69
CAS DataBase Reference: 461-72-3(CAS DataBase Reference)
NIST Chemistry Reference: 2,4-Imidazolidinedione(461-72-3)
EPA Substance Registry System: 2,4-Imidazolidinedione (461-72-3)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 24/25-36/37/39-27-26
WGK Germany: 3
RTECS: MT8210000
TSCA: Yes
HS Code: 29332100

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.04511
Product name: Hydantoin
Purity: for synthesis
Packaging: 100g
Price: $48.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.04511
Product name: Hydantoin
Purity: for synthesis
Packaging: 500g
Price: $164
Updated: 2024/03/01

Sigma-Aldrich

Product number: 156361
Product name: Hydantoin
Purity: 98%
Packaging: 100g
Price: $41.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: 156361
Product name: Hydantoin
Purity: 98%
Packaging: 500g
Price: $122
Updated: 2024/03/01

TCI Chemical

Product number: H0167
Product name: Hydantoin
Purity: >99.0%(T)
Packaging: 25g
Price: $23
Updated: 2024/03/01

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Hydantoin Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

The product has been used as a substrate (at 40 °C and pH 9.0) to determine the D-hydantoinase activity in adzuki bean extract.

Uses

Reactant for synthesis of: N-benzyl aplysinopsin analogs as anticancer agents, D-glutamic acid based inhibitors, Antidiabetic chromonyl-2,4-thiazolidinediones, GSK-3β, inhibitors with brain permeability, Thiazolidinedione derivatives as 15-PGDH inhibitors, and Radio-sensitizing agents.

Definition

ChEBI: Hydantoin is an imidazolidine-2,4-dione.

Pharmaceutical Applications

Control of generalized convulsive status epilepticus; prevention and treatment of seizures during neurosurgery; short-term substitute for oral phenytoin.

Mechanism of action

Hydantoins are a class of drugs mainly used to treat seizures (anticonvulsant or antiepileptic drugs). Hydantoins reduce seizures by targeting the sodium channel present throughout the nerves. Activation of sodium channels results in the conduction of electrical impulses and the release of neurotransmitters. It could stabilise neuronal membranes by decreasing sodium and calcium ion influx into the neurons. Also decreases post-tetanic potentiation and repetitive discharge.

Pharmacokinetics

Completely absorbed after IM administration. Protein binding: 95%–99%. Rapidly and completely hydrolyzed to phenytoin after IM or IV administration. Time of complete conversion to phenytoin: 4 hr after IM injection; 2 hr after IV infusion. Half-life: 8–15 min (for conversion to phenytoin).

Hydantoin Preparation Products And Raw materials

Raw materials

Orotic acid SYNTHETIC RESIN

Preparation Products

(S)-2-AMINO-3-(6-METHOXY-1H-INDOL-3-YL)-PROPIONIC ACID 5-METHOXY-DL-TRYPTOPHAN L-Valine S-α-cyano-3-phenoxy benzyl alcohol Glycine BANISTERINE MONOHYDRATE OROTIC ACID MONOHYDRATE

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View Lastest Price from Hydantoin manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Hydantoin 461-72-3
Price: US $99.00-35.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-16

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: Hydantoin 461-72-3
Price: US $100.00-75.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-21

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Hydantoin 461-72-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-12

461-72-3, HydantoinRelated Search:

Imidazolidinyl urea N-Vinyl-2-pyrrolidone Polyvinylpyrrolidone 1,3-Dibromo-5,5-dimethylhydantoin Ketoprofen Phenytoin sodium Imidazolidine Ethyltrichlorosilane tert-Butyl acetate Abiraterone acetate Ethylmagnesium bromide 2-Imidazolidone dehydroleucine 5 - (1-hydroxy-2-methylpropyl) hydantoin 4-methyl-2-oxopentadide 3-methyl-2-oxopentadide Iprodione Halogenated hydantoin

2,4-IMIDAZOLIDINEDIONE

2,4-IMIDAZOLINEDIONE

2,4-(3H,5H)-IMIDAZOLEDIONE

Imidazolidine-2,4-dione

HYDANTOIN

GLYCOLYLUREA

2-hydroxy-2-imidazolin-4(or5)-on

imidazole-2,4-dione

2-Imidazolin-4(or 5)-one, 2-hydroxy-

Imidazole-2,4(3H,5H)-dione

Hydantoin,99%

NSC 922

glycollylurea

2,4-Imidazolidinedione 、2-hydroxy-2-imidazolin-4(or 5)-on 、glycolylurea 、hydantoin

NSC 9226

2,5-Imidazolidinedione

Imidazolidine-2,5-dione

Glycolylurea 2,4-Imidazolidinedione

Hydantoin, 99% 100GR

HYDANTOIN FOR SYNTHESIS 100 G

HYDANTOIN FOR SYNTHESIS 500 G

Hydantoin , 99.0%(T)

CHEMICAL - HYDANTOIN LIKE COMPOUND - (DT

Hydantoin&gt

Maine

dimethyl-substituted hydantoin

461-72-3

C3H4N2O2

Heterocyclic Building Blocks

Imidazolines/Imidazolidines

Building Blocks

Chemical Synthesis

Heterocyclic Building Blocks

Chemical Amines

Amines

Heterocycles

Building Blocks

Heterocyclic Building Blocks

Imidazolines/Imidazolidines

FINE Chemical & INTERMEDIATES

Pharmaceutical Intermediates

bc0001

461-72-3