Hydantoin
- Product Name
- Hydantoin
- CAS No.
- 461-72-3
- Chemical Name
- Hydantoin
- Synonyms
- Imidazolidine-2,4-dione;2,4-IMIDAZOLIDINEDIONE;Maine;NSC 922;NSC 9226;HYDANTOIN;GLYCOLYLUREA;Hydantoin>Hydantoin,99%;glycollylurea
- CBNumber
- CB2352752
- Molecular Formula
- C3H4N2O2
- Formula Weight
- 100.08
- MOL File
- 461-72-3.mol
Hydantoin Property
- Melting point:
- 218-220 °C (lit.)
- Boiling point:
- 187.47°C (rough estimate)
- Density
- 1.4457 (rough estimate)
- vapor pressure
- 0Pa at 25℃
- refractive index
- 1.5110 (estimate)
- storage temp.
- Store below +30°C.
- solubility
- SLIGHTLY SOLUBLE
- pka
- pKa 9.1 (Uncertain)
- form
- Fine Powder
- color
- White to light yellow
- Water Solubility
- SLIGHTLY SOLUBLE
- Merck
- 14,4760
- BRN
- 110598
- LogP
- -1.69
- CAS DataBase Reference
- 461-72-3(CAS DataBase Reference)
- NIST Chemistry Reference
- 2,4-Imidazolidinedione(461-72-3)
- EPA Substance Registry System
- 2,4-Imidazolidinedione (461-72-3)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 24/25-36/37/39-27-26
- WGK Germany
- 3
- RTECS
- MT8210000
- TSCA
- Yes
- HS Code
- 29332100
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 8.04511
- Product name
- Hydantoin
- Purity
- for synthesis
- Packaging
- 100g
- Price
- $48.2
- Updated
- 2024/03/01
- Product number
- 8.04511
- Product name
- Hydantoin
- Purity
- for synthesis
- Packaging
- 500g
- Price
- $164
- Updated
- 2024/03/01
- Product number
- 156361
- Product name
- Hydantoin
- Purity
- 98%
- Packaging
- 100g
- Price
- $41.7
- Updated
- 2024/03/01
- Product number
- 156361
- Product name
- Hydantoin
- Purity
- 98%
- Packaging
- 500g
- Price
- $122
- Updated
- 2024/03/01
- Product number
- H0167
- Product name
- Hydantoin
- Purity
- >99.0%(T)
- Packaging
- 25g
- Price
- $23
- Updated
- 2024/03/01
Hydantoin Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
The product has been used as a substrate (at 40 °C and pH 9.0) to determine the D-hydantoinase activity in adzuki bean extract.
Uses
Reactant for synthesis of: N-benzyl aplysinopsin analogs as anticancer agents, D-glutamic acid based inhibitors, Antidiabetic chromonyl-2,4-thiazolidinediones, GSK-3β, inhibitors with brain permeability, Thiazolidinedione derivatives as 15-PGDH inhibitors, and Radio-sensitizing agents.
Definition
ChEBI: Hydantoin is an imidazolidine-2,4-dione.
Pharmaceutical Applications
Control of generalized convulsive status epilepticus; prevention and treatment of seizures during neurosurgery; short-term substitute for oral phenytoin.
Mechanism of action
Hydantoins are a class of drugs mainly used to treat seizures (anticonvulsant or antiepileptic drugs). Hydantoins reduce seizures by targeting the sodium channel present throughout the nerves. Activation of sodium channels results in the conduction of electrical impulses and the release of neurotransmitters. It could stabilise neuronal membranes by decreasing sodium and calcium ion influx into the neurons. Also decreases post-tetanic potentiation and repetitive discharge.
Pharmacokinetics
Completely absorbed after IM administration. Protein binding: 95%–99%. Rapidly and completely hydrolyzed to phenytoin after IM or IV administration. Time of complete conversion to phenytoin: 4 hr after IM injection; 2 hr after IV infusion. Half-life: 8–15 min (for conversion to phenytoin).
Hydantoin Preparation Products And Raw materials
Raw materials
Preparation Products
Hydantoin Suppliers
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View Lastest Price from Hydantoin manufacturers
- Product
- Hydantoin 461-72-3
- Price
- US $99.00-35.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-05-16
- Product
- Hydantoin 461-72-3
- Price
- US $100.00-75.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-21
- Product
- Hydantoin 461-72-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-01-12