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[3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL

Product Name
[3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL
CAS No.
206055-91-6
Chemical Name
[3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL
Synonyms
5-Isoxazolemethanol, 3-(4-bromophenyl)-;[3-(4-bromophenyl)-1,2-oxazol-5-yl]methanol;[3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL;[3-(4-bromophenyl)-5-(hydroxymethyl)]isoxazole
CBNumber
CB2353269
Molecular Formula
C10H8BrNO2
Formula Weight
254.08
MOL File
206055-91-6.mol
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[3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL Property

storage temp. 
2-8°C
form 
solid
InChI
1S/C10H8BrNO2/c11-8-3-1-7(2-4-8)10-5-9(6-13)14-12-10/h1-5,13H,6H2
InChIKey
CBTFIJPSRUYXHW-UHFFFAOYSA-N
SMILES
OCc1cc(no1)-c2ccc(Br)cc2
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
Storage Class
11 - Combustible Solids
Hazard Classifications
Acute Tox. 4 Oral
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
JRD0120
Product name
(3-(4-Bromophenyl)isoxazol-5-yl)methanol
Purity
Aldrich
Packaging
1g
Price
$259
Updated
2025/07/31
TRC
Product number
B698325
Product name
[3-(4-Bromo-phenyl)-isoxazol-5-yl]-methanol
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
B698325
Product name
[3-(4-Bromo-phenyl)-isoxazol-5-yl]-methanol
Packaging
500mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB51003
Product name
[3-(4-Bromophenyl)isoxazol-5-yl]methanol
Packaging
250mg
Price
$77.5
Updated
2021/12/16
AK Scientific
Product number
0564AB
Product name
(3-(4-Bromophenyl)isoxazol-5-yl)methanol
Packaging
1g
Price
$111
Updated
2021/12/16
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[3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL Chemical Properties,Usage,Production

Synthesis

107-19-7

29203-58-5

206055-91-6

The general procedure for the synthesis of 5-bromomethyl-3-(4-bromophenyl)-isoxazole from 2-propyn-1-ol and cis-4-bromo-A-chlorobenzaldehyde oxime was as follows: to 4-bromo-N-hydroxybenzenemethanimidoyl chloride (3.5 g, 14.9 mmol) synthesized in Step 2 of the Preparation of Example 6, alkyne-1-ol (2.74 mL, 45 mmol) and triethylamine ( Et3N, 7.7 mL) in dichloromethane (50 mL) and the reaction mixture was stirred at room temperature for 1.5 hours. Upon completion of the reaction, the reaction endpoint was confirmed by TLC. Subsequently, extraction was performed with dichloromethane (500 mL) and water (200 mL), and the organic layer was washed sequentially with water (100 mL x 2) and brine (50 mL). The organic layer was separated, dried with anhydrous magnesium sulfate, and the solvent was removed by filtration under reduced pressure. The residue was purified by silica gel column chromatography using ethyl acetate and hexane as the unfolding solvents to afford the target product 5-bromomethyl-3-(4-bromophenyl)-isoxazole (3-(4-bromophenyl)isoxazol-5-yl)methanol (11e). The yield was 69%.1H NMR (CDCl3, 400MHz) data were as follows: δ 7.66 (d, 2H, J = 2.4Hz), 7.64 (d, 2H, J = 1.6Hz), 6.53 (s, 1H), 4.81 (s, 2H).

References

[1] Journal of Medicinal Chemistry, 2003, vol. 46, # 2, p. 284 - 302
[2] Patent: US2010/63041, 2010, A1. Location in patent: Page/Page column 32
[3] Patent: WO2008/108602, 2008, A1. Location in patent: Page/Page column 51; 31-32

[3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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[3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL Suppliers

China 32 India 1 United Kingdom 1 United States 13 Global 47
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206055-91-6, [3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOLRelated Search:

(3-(4-(TRIFLUOROMETHYL)PHENYL)ISOXAZOL-5-YL)METHANOL [3-(2-CHLORO-PHENYL)-ISOXAZOL-5-YL]-METHANOL (3-BENZO[1,3]DIOXOL-5-YL-ISOXAZOL-5-YL)-METHANOL [3-(4-FLUORO-PHENYL)-ISOXAZOL-5-YL]-METHANOL [3-(2-METHOXY-PHENYL)-ISOXAZOL-5-YL]-METHANOL [3-(4-CHLOROPHENYL)-5-ISOXAZOLYL]METHANOL [3-(2-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL [3-(3-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL 3-(4-BROMOPHENYL)ISOXAZOLE [3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL

  • [3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL
  • [3-(4-bromophenyl)-1,2-oxazol-5-yl]methanol
  • [3-(4-bromophenyl)-5-(hydroxymethyl)]isoxazole
  • 5-Isoxazolemethanol, 3-(4-bromophenyl)-
  • 206055-91-6