[3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL

Product Name: [3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL
CAS No.: 206055-91-6
Chemical Name: [3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL
Synonyms: 5-Isoxazolemethanol, 3-(4-bromophenyl)-;[3-(4-bromophenyl)-1,2-oxazol-5-yl]methanol;[3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL;[3-(4-bromophenyl)-5-(hydroxymethyl)]isoxazole
CBNumber: CB2353269
Molecular Formula: C10H8BrNO2
Formula Weight: 254.08
MOL File: 206055-91-6.mol

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[3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL Property

storage temp.: 2-8°C
form: solid

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: JRD0120
Product name: (3-(4-Bromophenyl)isoxazol-5-yl)methanol
Purity: Aldrich
Packaging: 1g
Price: $259
Updated: 2025/07/31

TRC

Product number: B698325
Product name: [3-(4-Bromo-phenyl)-isoxazol-5-yl]-methanol
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B698325
Product name: [3-(4-Bromo-phenyl)-isoxazol-5-yl]-methanol
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB51003
Product name: [3-(4-Bromophenyl)isoxazol-5-yl]methanol
Packaging: 250mg
Price: $77.5
Updated: 2021/12/16

AK Scientific

Product number: 0564AB
Product name: (3-(4-Bromophenyl)isoxazol-5-yl)methanol
Packaging: 1g
Price: $111
Updated: 2021/12/16

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[3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL Chemical Properties,Usage,Production

Synthesis

107-19-7

29203-58-5

206055-91-6

The general procedure for the synthesis of 5-bromomethyl-3-(4-bromophenyl)-isoxazole from 2-propyn-1-ol and cis-4-bromo-A-chlorobenzaldehyde oxime was as follows: to 4-bromo-N-hydroxybenzenemethanimidoyl chloride (3.5 g, 14.9 mmol) synthesized in Step 2 of the Preparation of Example 6, alkyne-1-ol (2.74 mL, 45 mmol) and triethylamine ( Et3N, 7.7 mL) in dichloromethane (50 mL) and the reaction mixture was stirred at room temperature for 1.5 hours. Upon completion of the reaction, the reaction endpoint was confirmed by TLC. Subsequently, extraction was performed with dichloromethane (500 mL) and water (200 mL), and the organic layer was washed sequentially with water (100 mL x 2) and brine (50 mL). The organic layer was separated, dried with anhydrous magnesium sulfate, and the solvent was removed by filtration under reduced pressure. The residue was purified by silica gel column chromatography using ethyl acetate and hexane as the unfolding solvents to afford the target product 5-bromomethyl-3-(4-bromophenyl)-isoxazole (3-(4-bromophenyl)isoxazol-5-yl)methanol (11e). The yield was 69%.1H NMR (CDCl3, 400MHz) data were as follows: δ 7.66 (d, 2H, J = 2.4Hz), 7.64 (d, 2H, J = 1.6Hz), 6.53 (s, 1H), 4.81 (s, 2H).

References

[1] Journal of Medicinal Chemistry, 2003, vol. 46, # 2, p. 284 - 302
[2] Patent: US2010/63041, 2010, A1. Location in patent: Page/Page column 32
[3] Patent: WO2008/108602, 2008, A1. Location in patent: Page/Page column 51; 31-32

[3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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[3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL Suppliers

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206055-91-6, [3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOLRelated Search:

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[3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL

[3-(4-bromophenyl)-1,2-oxazol-5-yl]methanol

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206055-91-6