[3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL

Product Name: [3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL
CAS No.: 206055-91-6
Chemical Name: [3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL
Synonyms: 5-Isoxazolemethanol, 3-(4-bromophenyl)-;[3-(4-bromophenyl)-1,2-oxazol-5-yl]methanol;[3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL;[3-(4-bromophenyl)-5-(hydroxymethyl)]isoxazole
CBNumber: CB2353269
Molecular Formula: C10H8BrNO2
Formula Weight: 254.08
MOL File: 206055-91-6.mol

More

Less

[3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL Property

storage temp.: 2-8°C
form: solid

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: JRD0120
Product name: (3-(4-Bromophenyl)isoxazol-5-yl)methanol
Purity: Aldrich
Packaging: 1g
Price: $259
Updated: 2025/07/31

TRC

Product number: B698325
Product name: [3-(4-Bromo-phenyl)-isoxazol-5-yl]-methanol
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B698325
Product name: [3-(4-Bromo-phenyl)-isoxazol-5-yl]-methanol
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB51003
Product name: [3-(4-Bromophenyl)isoxazol-5-yl]methanol
Packaging: 250mg
Price: $77.5
Updated: 2021/12/16

AK Scientific

Product number: 0564AB
Product name: (3-(4-Bromophenyl)isoxazol-5-yl)methanol
Packaging: 1g
Price: $111
Updated: 2021/12/16

More

Less

[3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL Chemical Properties,Usage,Production

Synthesis

107-19-7

29203-58-5

206055-91-6

The general procedure for the synthesis of 5-bromomethyl-3-(4-bromophenyl)-isoxazole from 2-propyn-1-ol and cis-4-bromo-A-chlorobenzaldehyde oxime was as follows: to 4-bromo-N-hydroxybenzenemethanimidoyl chloride (3.5 g, 14.9 mmol) synthesized in Step 2 of the Preparation of Example 6, alkyne-1-ol (2.74 mL, 45 mmol) and triethylamine ( Et3N, 7.7 mL) in dichloromethane (50 mL) and the reaction mixture was stirred at room temperature for 1.5 hours. Upon completion of the reaction, the reaction endpoint was confirmed by TLC. Subsequently, extraction was performed with dichloromethane (500 mL) and water (200 mL), and the organic layer was washed sequentially with water (100 mL x 2) and brine (50 mL). The organic layer was separated, dried with anhydrous magnesium sulfate, and the solvent was removed by filtration under reduced pressure. The residue was purified by silica gel column chromatography using ethyl acetate and hexane as the unfolding solvents to afford the target product 5-bromomethyl-3-(4-bromophenyl)-isoxazole (3-(4-bromophenyl)isoxazol-5-yl)methanol (11e). The yield was 69%.1H NMR (CDCl3, 400MHz) data were as follows: δ 7.66 (d, 2H, J = 2.4Hz), 7.64 (d, 2H, J = 1.6Hz), 6.53 (s, 1H), 4.81 (s, 2H).

References

[1] Journal of Medicinal Chemistry, 2003, vol. 46, # 2, p. 284 - 302
[2] Patent: US2010/63041, 2010, A1. Location in patent: Page/Page column 32
[3] Patent: WO2008/108602, 2008, A1. Location in patent: Page/Page column 51; 31-32

[3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

[3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL Suppliers

China 31 India 1 United Kingdom 1 United States 13 Global 46

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

Chengdu Forest Science and Technology Development Co., Ltd.

Tel: 18030648795
Fax: 028-61777050
Email: sales@cdforestchem.com
Country: China
ProdList: 1998
Advantage: 58

Changzhou Hopschain Chemical Co.,Ltd.

Tel: 0519-85528066 13775048983
Fax: 0519-85528066
Email: sales@hopschem.com
Country: China
ProdList: 31553
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai Anmike Chemical Co. Ltd.

Tel: 微信 17321281695 18019252918
Fax: 021-31261685
Email: sale@amkchem.com
Country: China
ProdList: 9405
Advantage: 55

Aikon International Limited

Tel: 025-66113011 13155353615
Fax: (7)02557626880
Email: qzhang@aikonchem.com
Country: China
ProdList: 15394
Advantage: 58

Henan Aosman Biotechnology Co., LTD

Tel: 0371-0371-61318675 17719817155
Fax: 0371-61318675
Email: sales@xlinebio.com
Country: China
ProdList: 2857
Advantage: 58

3A Chemicals

Tel: 400-668-9898
Fax: 010-51582189
Email: service@3achem.com
Country: China
ProdList: 20557
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Cool Pharm, Ltd

Tel: 021-58581007 18019463053
Fax: 021-50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12878
Advantage: 58

206055-91-6, [3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOLRelated Search:

(3-(4-(TRIFLUOROMETHYL)PHENYL)ISOXAZOL-5-YL)METHANOL [3-(2-CHLORO-PHENYL)-ISOXAZOL-5-YL]-METHANOL (3-BENZO[1,3]DIOXOL-5-YL-ISOXAZOL-5-YL)-METHANOL [3-(4-FLUORO-PHENYL)-ISOXAZOL-5-YL]-METHANOL [3-(2-METHOXY-PHENYL)-ISOXAZOL-5-YL]-METHANOL [3-(4-CHLOROPHENYL)-5-ISOXAZOLYL]METHANOL [3-(2-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL [3-(3-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL 3-(4-BROMOPHENYL)ISOXAZOLE [3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL

[3-(4-BROMO-PHENYL)-ISOXAZOL-5-YL]-METHANOL

[3-(4-bromophenyl)-1,2-oxazol-5-yl]methanol

[3-(4-bromophenyl)-5-(hydroxymethyl)]isoxazole

5-Isoxazolemethanol, 3-(4-bromophenyl)-

206055-91-6