ChemicalBook > CAS DataBase List > Metacycline hydrochloride

Metacycline hydrochloride

Product Name
Metacycline hydrochloride
CAS No.
3963-95-9
Chemical Name
Metacycline hydrochloride
Synonyms
METACYCLINE;METHACYCLINE HYDROCHLORIDE;METHACYCLINE HCL;METACYCLINE HCL;optimycin;MethacycL;metadomus;londomycin;megamycine;adriamicina
CBNumber
CB2355197
Molecular Formula
C22H23ClN2O8
Formula Weight
478.88
MOL File
3963-95-9.mol
More
Less

Metacycline hydrochloride Property

Melting point:
>224°C(dec.)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated), Water (Slightly)
form 
Crystalline Powder
color 
Yellow
BRN 
5470951
CAS DataBase Reference
3963-95-9
EPA Substance Registry System
Methacycline hydrochloride (3963-95-9)
More
Less

Safety

Safety Statements 
24/25-22
WGK Germany 
2
RTECS 
QI9276000
HS Code 
29413020
Toxicity
LD50 in rats, mice (mg/kg): 252, 288 i.p. (Goldenthal)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1594
Product name
Methacycline hydrochloride
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1g
Price
$173
Updated
2024/03/01
Sigma-Aldrich
Product number
1397006
Product name
Methacycline hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
Cayman Chemical
Product number
21338
Product name
Methacycline (hydrochloride)
Purity
≥98%
Packaging
1g
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21338
Product name
Methacycline (hydrochloride)
Purity
≥98%
Packaging
5g
Price
$63
Updated
2024/03/01
Cayman Chemical
Product number
21338
Product name
Methacycline (hydrochloride)
Purity
≥98%
Packaging
10g
Price
$93
Updated
2024/03/01
More
Less

Metacycline hydrochloride Chemical Properties,Usage,Production

Description

Methacycline is a tetracycline-class antibiotic that is active against a wide range of Gram-positive and Gram-negative organisms. It is readily absorbed from the gastrointestinal tract and reaches a maximum concentration at about the fourth hour, declining to a negligible amount in about 24 hours. It is more active than tetracycline against a number of bacteria.

Chemical Properties

yellow crystalline powder

Originator

Rondomycin ,Pfizer ,UK ,1963

Uses

Broad spectrum, semisynthetic antibiotic related to Tetracycline. Antibacterial.

Uses

Methacycline hydrochloride is a salt prepared from methacycline taking advantage of the basic dimethylamino group which protonates and readily forms a salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, methacycline hydrochloride shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal subunits, blocking protein synthesis.

Uses

analgesic, narcotic antagonist

Uses

A broad spectrum, anti bacterial, semisynthetic antibiotic related to Tetracycline

Definition

ChEBI: Methacycline hydrochloride is an organic molecular entity.

Manufacturing Process

To a stirred solution of 4.6 g (0.01 mol) of anhydrous oxytetracycline in 40 ml of dry tetrahydrofuran is added 3.5 g (0.021 mol) of pyridine-sulfur trioxide complex. After 16 hours of stirring at room temperature, the resulting suspension is filtered, and the solid is slurried with 25 ml of 2% hydrochloric acid for 10 minutes, filtered and thoroughly washed with methanol followed by ether. The pale yellow crystalline 5-oxytetracycline-6,12-hemiketal-12-sulfuric acid ester melts at 210°C.
500 mg 5-oxytetracycline-6,12-hemiketal-12-sulfuric acid ester, prepared as described, is added to 4 ml dry liquid hydrogen fluoride, and the mixture is stirred for 1.5 hours at ice bath temperature. The hydrogen fluoride is then evaporated in a stream of nitrogen and the resulting gummy solids are triturated with about 15 ml ether and filtered. The resulting solid hydrofluoride salt is further purified by suspending in water, adjusting the pH to about 4, and extracting the 6-methylene-5-oxytetracycline free base from the aqueous phase with ethyl acetate. The extract is separated and evaporated to dryness under reduced pressure. The resulting residue is triturated with ether and filtered, and the solid is recrystallized from methanol-acetone-etherconcentrated hydrochloric acid to obtain the product as a purified hydrochloride, according to US Patent 3,026,354.

brand name

Rondomycin (Medpointe).

Therapeutic Function

Antibiotic

General Description

The synthesis of methacycline, 6-deoxy-6-demethyl-6-methylene-5-oxytetracycline hydrochloride (Rondomycin), reportedby Blackwood et al. in 1961, was accomplished bychemical modification of oxytetracycline. It has an antibioticspectrum like that of the other tetracyclines but greater potency;about 600 mg of methacycline is equivalent to 1 g oftetracycline. Its particular value lies in its longer serum halflife;doses of 300 mg produce continuous serum antibacterialactivity for 12 hours. Its toxic manifestations and contraindicationsare similar to those of the other tetracyclines.
The greater stability of methacycline, both in vivo and invitro, results from modification at C-6. Removal of the 6-hydroxy group markedly increases the stability of ring C toboth acids and bases, preventing the formation of isotetracyclinesby bases. Anhydrotetracyclines still can form, however,by acid-catalyzed isomerization under strongly acidicconditions. Methacycline hydrochloride is a yellow to darkyellow, crystalline powder that is slightly soluble in waterand insoluble in nonpolar solvents. It should be stored intight, light-resistant containers in a cool place.

Metacycline hydrochloride Preparation Products And Raw materials

Raw materials

Oxytetracycline

Preparation Products

More
Less

Metacycline hydrochloride Suppliers

Australia 1 Austria 1 Belgium 4 Canada 2 China 195 France 1 Germany 6 India 9 Japan 1 South Korea 1 Switzerland 3 The Netherlands 1 United Kingdom 9 United States 26 Venezuela 1 Global 261
Hubei Weideli Chemical Reagent Co.，Ltd.
Tel
13339985473
Email
C13339985473@163.com
Country
China
ProdList
3458
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94838
Advantage
76
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9551
Advantage
66
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8849
Advantage
52
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4550
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4654
Advantage
58
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
4969
Advantage
50
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9872
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17779
Advantage
75
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12338
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9901
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19918
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
18521735133 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25015
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9552
Advantage
55
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3750
Advantage
55
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8073
Advantage
58
Wuhan DKY Technology Co.,Ltd.
Tel
27-81302488 18007166089
Fax
027-81302088
Email
info@dkybpc.com
Country
China
ProdList
2024
Advantage
58
TianJin Alta Scientific Co., Ltd.
Tel
022-65378550-8551
Fax
+86-022-2532-9655
Email
contact@altascientific.com
Country
China
ProdList
2773
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41438
Advantage
60
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9636
Advantage
58
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4951
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15878
Advantage
55
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9911
Advantage
50
Hangzhou J&H Chemical Co., Ltd.
Tel
+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
10015
Advantage
53
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2989
Advantage
60
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9767
Advantage
58
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9503
Advantage
50
Alta Scientific Co., Ltd.
Tel
022-6537-8550 15522853686
Fax
022-2532-9655
Email
sales@altasci.com.cn
Country
China
ProdList
4515
Advantage
55
ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862，442785678，326799392 18721037013
Fax
021-50908862
Email
siyansales@126.com
Country
China
ProdList
9638
Advantage
58
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3868
Advantage
58
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9604
Advantage
55
Raw material medicin reagent co.,Ltd
Tel
025-57798860
Email
sales@njromanme.com
Country
China
ProdList
4534
Advantage
58
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14623
Advantage
60
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29797
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131981
Advantage
58
Shanghai Civic Chemical Technology Co., Ltd.
Tel
021-34053660
Fax
QQ:2881074831
Email
sale2@labgogo.com
Country
China
ProdList
2018
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12308
Advantage
58
Shenzhen Sendi Biological Technology Co., Ltd.
Tel
18124570582 TEL：0755-23574479 2355327139
Fax
0755-23229476 QQ: 2355327139
Email
siliao02@yccreate.com
Country
China
ProdList
6120
Advantage
58
Hubei widely chemical technology Co., Ltd.
Tel
027-59402396 13419635609
Fax
027-83989310
Email
13419635609@163.com
Country
China
ProdList
1994
Advantage
55
Wuhan Wsem Biological Co., Ltd.
Tel
027-83778876 13667159345
Fax
027-83778876
Email
13667159345@163.com
Country
China
ProdList
1942
Advantage
55
Wuhan Magic Biological Technology Co., Ltd.
Tel
18872289958、027-52304252、3400508168
Fax
027-52304252
Email
3400508168@qq.com
Country
China
ProdList
1910
Advantage
55
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
Country
China
ProdList
4587
Advantage
58
Shanghai Kangman Biological Technology Co., Ltd.
Tel
18800375331
Fax
021-50908862
Email
kangmansales@163.com
Country
China
ProdList
7580
Advantage
55
Wellman Pharmaceutical Group Limited
Tel
027-027-83778875 15807197853
Fax
027-83991220
Email
15807197853@163.com
Country
China
ProdList
3978
Advantage
58
Taian Jiaye Biotechnology Co.Ltd
Tel
13127280945
Email
285424065@qq.com
Country
China
ProdList
9980
Advantage
55
More
Less

View Lastest Price from Metacycline hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Metacycline hydrochloride 3963-95-9
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
1000kg
Release date
2021-10-27
Baoji Guokang Bio-Technology Co., Ltd.
Product
Metacycline hydrochloride 3963-95-9
Price
US $210.00/Kg/Bag
Min. Order
1KG
Purity
USP
Supply Ability
1T
Release date
2021-06-03
Zhuozhou Wenxi import and Export Co., Ltd
Product
Methacycline hydrochloride 3963-95-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

3963-95-9, Metacycline hydrochloride Related Search:

Phenylhydrazine hydrochloride Ceftiofur sodium Lincomycin hydrochloride Josamycin Moxifloxacin hydrochloride Mestinon Tariquidar Trifluridine Formestane Floxuridine Norvoncomycin hydrochloride BETAZOLE HYDROCHLORIDE Xylazine Hydrochloride SPECTINOMYCIN DIHYDROCHLORIDE Hydralazine hydrochloride Oxytetracycline METHACYCLINE HCL,METHACYCLINE HYDROCHLORIDE,Methacycline Hydrochloride BP73/USP25 1-ACETYL-1-CYCLOHEXENE

  • Methacycline HCl (PhysioMycine)
  • Rondomycin hydrochloride
  • 6-Methyleneoxytetracycline hydrochloride, Metacycline hydrochloride, LondoMycin
  • (4S,4aR,5S,5aR,12aS)- 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-2-naphthacenecarboxamide, hydrochloride (1:1)
  • Methacycline hydrochloride Solution, 100ppm
  • Hydrochloric acid methacycline
  • 6-DEMETHYL-6-DEOXY-6-METHYLENEOXYTETRACYCLINE MONOHYDROCHLORIDE
  • 6-DEMETHYL-6-DEOXY-6-METHYLENEOXYTETRACYCLNE HYDROCHLORIDE
  • METACYCLINE
  • METACYCLINE HCL
  • METACYCLINE HYDROCHLORIDE
  • METHACYCLINE HCL
  • METHACYCLINE HYDROCHLORIDE
  • 12,12a-pentahydroxy-6-methylene-1,11-dioxo-1monohydrochloride
  • metilenbiotic
  • optimycin
  • physiomycine
  • Metacycline hydrochloride, sec. Standard, 98%
  • 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-, monohydrochloride, (4S,4aR,5S,5aR,12aS)-
  • METHACYCLINE HYDROCHLORIDE (METACYCLINE HYDROCHLORIDE)
  • METACYCLINE HYDROCHLORIDE, 98%, SEC. STANDARD
  • MethacycL
  • Methacycline hydrochlorid
  • 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-, monohydrochloride
  • Metacycline, Adramycin, Rondomycin, Pindex
  • Methacycline hydrochloride, potency: 877 u/mg
  • Metacylcline HLC
  • (4S,4aR,5S,5aR,12aS)-4-(DiMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-Methylene-1,11-dioxo-2-naphthacenecarboxaMide HCl
  • Methacycline hydrochloride (PhysioMycine)
  • adriamicina
  • ciclobiotic
  • germiciclin
  • globociclina
  • londomycin
  • megamycine
  • metadomus
  • methacyclinemonohydrochloride
  • Metacyclin hydrochloride
  • Methacycline Hydrochloride (200 mg)
  • Methacycline Hydrochloride (200 mg)I0C348903ug/mg(ai)
  • Metacycline hydrochloride USP/EP/BP
  • (4S,4aR,5S,5aR,12aS)-4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride
  • Methacycline HydrochlorideQ: What is Methacycline Hydrochloride Q: What is the CAS Number of Methacycline Hydrochloride Q: What is the storage condition of Methacycline Hydrochloride Q: What are the applications of Methacycline Hydrochloride
  • Metacyclinhydrochlorid
  • Methacycline Hydrochloride (1397006)
  • Doxycycline EP Impurity B / Methacycline Impurity
  • (4S,4Ar,5S,5aR,12aS)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methylidene-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide
  • Doxycycline Hyclate EP Impurity B as Hydrochloride
  • Doxycycline Hyclate Impurity B as Hydrochloride
  • Doxycycline EP Impurity B（HCl）
  • Methicycline hydrochloride
  • Methacylcycline Hydrochloride
  • 3963-95-9
  • C22H22N2O8ClH
  • Amines
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals