3-Iodo-6-nitroindazole
- Product Name
- 3-Iodo-6-nitroindazole
- CAS No.
- 70315-70-7
- Chemical Name
- 3-Iodo-6-nitroindazole
- Synonyms
- Axitinib Intermediate;3-Iodo-6-nitroindazol;3-IODO-6-NITROINDAZOLE;3-LODO-6-NITROINDAZOLE;Axitinib Intermediate 1;3-iodo-6-nitro-2h-indazole;3-IODO-6-NITRO (1H)INDAZOLE;1H-Indazole, 3-iodo-6-nitro-;3-Iodo-6-nitro-1H-indazole ,97%;3-Iodo-6-nitro-1H-indazole
- CBNumber
- CB2357025
- Molecular Formula
- C7H4IN3O2
- Formula Weight
- 289.03
- MOL File
- 70315-70-7.mol
3-Iodo-6-nitroindazole Property
- Melting point:
- 259-261 °C
- Boiling point:
- 458.0±25.0 °C(Predicted)
- Density
- 2.24
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- powder to crystal
- pka
- 9.12±0.40(Predicted)
- color
- Light yellow to Yellow to Orange
- InChI
- InChI=1S/C7H4IN3O2/c8-7-5-2-1-4(11(12)13)3-6(5)9-10-7/h1-3H,(H,9,10)
- InChIKey
- GZCGNGLOCQEDMT-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC([N+]([O-])=O)=C2)C(I)=N1
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-60
- Safety Statements
- 53-22-36/37/39-45
- WGK Germany
- 3
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SYX00220
- Product name
- 3-Iodo-6-nitro-1H-indazole
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $216
- Updated
- 2025/07/31
- Product number
- I1004
- Product name
- 3-Iodo-6-nitroindazole
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $122
- Updated
- 2025/07/31
- Product number
- I1004
- Product name
- 3-Iodo-6-nitroindazole
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $371
- Updated
- 2025/07/31
- Product number
- I715720
- Product name
- 3-Iodo-6-nitro-1H-indazole
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR305075
- Product name
- 3-Iodo-6-nitro-1H-indazole
- Packaging
- 1g
- Price
- $31
- Updated
- 2021/12/16
3-Iodo-6-nitroindazole Chemical Properties,Usage,Production
Chemical Properties
Yellow solid
Synthesis
7597-18-4
70315-70-7
General procedure for the synthesis of 3-iodo-6-nitroindazole from 6-nitro-1H-indazole: 6-nitroindazole (45.08 kg) was dissolved in N,N-dimethylformamide (DMF, 228 kg), and powdered potassium carbonate (77 kg) was added while controlling the temperature of the reaction system ≤30°C. The reaction was carried out by slow dropwise addition of iodine (123 kg) solution in DMF (100 kg) over 5 to 6 hours. A solution of iodine (123 kg) dissolved in DMF (100 kg) was added slowly and dropwise over a period of 5 to 6 hours, during which the reaction temperature was maintained at ≤35°C (note: the reaction is exothermic). The reaction mixture was stirred continuously at 22°C for 1 to 5 hours until high performance liquid chromatography (HPLC) monitoring showed that the reaction was complete. Subsequently, the reaction mixture was slowly added to an aqueous solution (455 kg) containing sodium thiosulfate (68 kg) and potassium carbonate (0.46 kg) and the temperature was controlled to be ≤30°C during addition. The mixture was continued to be stirred at 22°C for 1.5 hours. Water (683 kg) was added to precipitate the product and the slurry was stirred at 22°C for 1 to 2 hours. The solid product was collected by filtration, washed with water (2 x 46 kg) and subsequently dried in a vacuum oven at 50 °C and 25 mmHg for 24 to 48 hours to give a yellowish-white solid 3-iodo-6-nitroindazole (74.7 kg, HPLC purity 86.6%, moisture content 0.2%).
References
[1] Organic Process Research and Development, 2015, vol. 19, # 7, p. 849 - 857
[2] Patent: WO2009/36066, 2009, A1. Location in patent: Page/Page column 51
[3] Patent: WO2006/48745, 2006, A1. Location in patent: Page/Page column 21
[4] Patent: WO2006/48761, 2006, A2. Location in patent: Page/Page column 30
[5] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 5, p. 1327 - 1333
3-Iodo-6-nitroindazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Iodo-6-nitroindazole manufacturers
- Product
- 3-Iodo-6-nitro-1H-indazole 70315-70-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100kg/month
- Release date
- 2023-01-05
- Product
- 3-iodo-6-nitro-1H-indazole 70315-70-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-27
- Product
- 3-Iodo-6-nitro-1H-indazole 70315-70-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100
- Release date
- 2022-02-26