2-Methyl-5-nitroaniline
- Product Name
- 2-Methyl-5-nitroaniline
- CAS No.
- 99-55-8
- Chemical Name
- 2-Methyl-5-nitroaniline
- Synonyms
- FAST SCARLET G BASE;5-NITRO-O-TOLUIDINE;2-AMINO-4-NITROTOLUENE;PNOT;SCARLET G BASE;pnot[qr];CI 37105;NCI-C01843;dahongseji;ci37105[qr]
- CBNumber
- CB7234387
- Molecular Formula
- C7H8N2O2
- Formula Weight
- 152.15
- MOL File
- 99-55-8.mol
2-Methyl-5-nitroaniline Property
- Melting point:
- 103-106 °C(lit.)
- Boiling point:
- 294.61°C (rough estimate)
- Density
- 1.2333 (estimate)
- refractive index
- 1.6276 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Crystalline Powder
- pka
- 2.34±0.10(Predicted)
- color
- Ochre to yellow-orange
- Water Solubility
- <0.1 g/100 mL at 19 ºC
- BRN
- 879021
- Exposure limits
- ACGIH: TWA 1 mg/m3
- Stability:
- Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, acids, chloroformates.
- CAS DataBase Reference
- 99-55-8(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzenamine, 2-methyl-5-nitro-(99-55-8)
- IARC
- 3 (Vol. 48) 1990
- EPA Substance Registry System
- 2-Methyl-5-nitroaniline (99-55-8)
Safety
- Hazard Codes
- T,Xi
- Risk Statements
- 23/24/25-40-52/53
- Safety Statements
- 36/37-45-61
- RIDADR
- UN 2660 6.1/PG 3
- WGK Germany
- 3
- RTECS
- XU8225000
- Hazard Note
- Irritant
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29214300
- Hazardous Substances Data
- 99-55-8(Hazardous Substances Data)
- Toxicity
- LD50 orl-rat: 574 mg/kg NCIMR* NIH-71-E-2144,73
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H351Suspected of causing cancer
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- M59386
- Product name
- 2-Methyl-5-nitroaniline
- Purity
- 98%
- Packaging
- 100g
- Price
- $62.7
- Updated
- 2024/03/01
- Product number
- 402729
- Product name
- 2-Methyl-5-nitroaniline
- Purity
- 95%
- Packaging
- 100g
- Price
- $104
- Updated
- 2023/06/20
- Product number
- 45984
- Product name
- 2-Methyl-5-nitroaniline
- Purity
- analytical standard
- Packaging
- 100mg
- Price
- $51.1
- Updated
- 2022/05/15
- Product number
- N0115
- Product name
- 2-Methyl-5-nitroaniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $44
- Updated
- 2024/03/01
- Product number
- N0115
- Product name
- 2-Methyl-5-nitroaniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 500g
- Price
- $520
- Updated
- 2024/03/01
2-Methyl-5-nitroaniline Chemical Properties,Usage,Production
Description
2-Methyl-5-nitroaniline, also known as 5-nitro-o-toluidine, is an intermediate compound in the synthesis of a wide range of azo dyes and is an in vivo metabolic product of 2,4-dinitrotoluene.
Chemical Properties
5-Nitro-o-toluidine is a yellow, crystalline solid.
Uses
2-Methyl-5-nitroaniline may be employed as analytical standard for the surfactant mediated transformations (?254nm) of 2,4-dinitrotoluene.
Uses
5-Nitro-o-toluidine is used in the synthesis of numerous dyes.
Preparation
2-Methyl-5-nitrobenzenamine?in concentrated sulfuric acid nitration.
Preparation
o-Toluidine(500 mg, 4.19 mmol) was added with vigorous stirring to a balloon with concentrated sulfuric acid (3.9 ml, 71.4 mmol). The temperature of the reaction is 10 ℃ (salt/ice, cold bath). After that, an acid mixture (0.9 mlHNO3 and 0.9 ml H2SO4) was added to the solution for 2 h. The mixture was placed on ice and basified with NaOH. Finally, 2-methyl-5-nitroaniline was collected by filtration and washed with water.
Definition
ChEBI: A C-nitro compound in which the nitro compound is meta to the amino group and para to the methyl group of o-toluidine.
Air & Water Reactions
Insoluble in water. 2-Methyl-5-nitroaniline is sensitive to moisture, light, or prolonged exposure to air.
Reactivity Profile
2-Methyl-5-nitroaniline is incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides and chloroformates.
Fire Hazard
Flash point data for 2-Methyl-5-nitroaniline are not available; however, 2-Methyl-5-nitroaniline is probably combustible.
Toxicology
Genetic toxicity studies for 2-methyl-5-nitroaniline indicate generally positive results in reverse-mutation assays in Salmonella typhimurium and Escherichia coli, and in Syrian hamster embryo (SHE) cell transformation assays; the compound is weaker in potency than other 2,4-dinitrotoluene metabolites.
Safety Profile
Confirmed carcinogen with experimental carcinogenic data. Moderately toxic by ingestion. Mutation data reported. Decomposes exothermically when heated to 150℃. When heated to decomposition it emits toxic fumes of NOx. See also NITRO COMPOUNDS OF AROMATIC HYDROCARBONS.
Carcinogenicity
There are no data available for evaluating carcinogenic risk to humans. When 5-nitro-o-toluidine was administered in a dietary feeding study to F344 rats (50 or 100 ppm) and B6C3F1 mice (1200 or 2300 ppm) of both sexes, hepatocellular carcinomas were produced in mice but not in rats.
Shipping
UN2660 Nitrotoluidines (mono), Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Purification Methods
Acetylate the aniline, and the acetyl derivative is crystallised to constant melting point; then hydrolyse it with 70% H2SO4 and the free base is regenerated by treatment with NH3 [Bevan et al. J Chem Soc 4284 1956]. [Beilstein 12 H 844. 12 IV 1807.]
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, acid chlorides; acid anhydrides; chloroformates.
Waste Disposal
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.
2-Methyl-5-nitroaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Methyl-5-nitroaniline manufacturers
- Product
- 2-Methyl-5-nitroaniline 99-55-8
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-16
- Product
- 2-Methyl-5-nitroaniline 99-55-8
- Price
- US $50.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5000KG
- Release date
- 2023-08-16
- Product
- 2-Methyl-5-nitroaniline 99-55-8
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2023-02-21