Vinflunine

ChemicalBook > CAS DataBase List > Vinflunine

Product Name: Vinflunine
CAS No.: 162652-95-1
Chemical Name: Vinflunine
Synonyms: VINFLUNINE;vinflunine（97%）;Vinflunine Tartrate;Vinflunine (F12158);Vinflunine USP/EP/BP;Vinflunine 162652-95-1;20',20'-Difluoro-3',4'-dihydrovinorelbine;4'-Deoxy-20',20'-difluoro-8'-norvincaleukoblastine;4'-Deoxy-20',20'-difluoro-5'-norvincaleukoblastine;Aspidospermidine-3-carboxylicacid,4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-1
CBNumber: CB2358406
Molecular Formula: C45H54F2N4O8
Formula Weight: 816.94
MOL File: 162652-95-1.mol

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Vinflunine Property

Density: 1.39±0.1 g/cm3(Predicted)
pka: 11.36±0.60(Predicted)
CAS DataBase Reference: 162652-95-1(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0004596
Product name: VINFLUNINE
Purity: 95.00%
Packaging: 5MG
Price: $501.95
Updated: 2021/12/16

Crysdot

Product number: CD31003132
Product name: Vinflunine
Purity: 98+%
Packaging: 100mg
Price: $966
Updated: 2021/12/16

AvaChem

Product number: 2180
Product name: Vinflunine
Packaging: 100mg
Price: $1680
Updated: 2021/12/16

Crysdot

Product number: CD31003132
Product name: Vinflunine
Purity: 98+%
Packaging: 5mg
Price: $88
Updated: 2021/12/16

AvaChem

Product number: 2180
Product name: Vinflunine
Packaging: 5mg
Price: $135
Updated: 2021/12/16

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Vinflunine Chemical Properties,Usage,Production

Description

Vinflunine (also referred to as PM391) is a semisynthetic analog of the natural vinca alkaloids vinblastine and vincristine that was approved by the European Medicines Agency (EMEA) in 2009 for the treatment of adult patients with advanced or metastatic transitional cell carcinoma of the urothelial tract after failure of a prior platinum-containing regimen. Vinflunine is synthesized from anhydrovinblastine in a superacid media (HF-SbF₅) and in the presence of a chlorinated solvent like CHCl₃ or CCl₄.

Originator

Pierre Fabre (France)

Definition

ChEBI: An organic heteropentacyclic compound and an organic heterotetracyclic compound that is vinorelbine in which the tetrahydropyridine moiety of the heterotetracyclic part of the molecule has been redced to the corresponding piperidine, and in which the ethy group attached to this ring has been replaced by a 1,1-difluoroethyl group.

brand name

Javlor

Clinical Use

Antineoplastic agent (vinca alkaloid):
Treatment of advanced or metastatic bladder cancer

Drug interactions

Potentially hazardous interactions with other drugs
Antibacterials: possible increased risk of ventricular arrhythmias with delamanid; concentration possibly reduced by rifampicin - avoid.
Antidepressants: concentration possibly reduced by St Johns wort - avoid.
Antifungals: concentration increased by ketoconazole and possibly itraconazole (increased risk of neurotoxicity) - avoid.
Antimalarials: avoid with piperaquine with artenimol.
Antipsychotics: avoid with clozapine (increased risk of agranulocytosis).
Antivirals: concentration possibly increased by ritonavir - avoid.
Grapefruit juice: concentration of vinflunine increased - avoid.

Metabolism

Metabolised by the cytochrome CYP3A4 isoenzyme, except for 4-O-deacetylvinflunine (DVFL), the only active metabolite and main metabolite in blood which is formed by multiple esterases. Excretion occurs via the faeces (about two-thirds) and the urine (about one-third).

Vinflunine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Vinflunine manufacturers

NanJing Spring & Autumn Biological Engineering CO., LTD.

Product: Vinflunine 162652-95-1 162652-95-1
Price: US $30.00/mg
Min. Order: 20mg
Purity: ≥98%
Supply Ability: 1000.00 kgs
Release date: 2019-07-17

Career Henan Chemical Co

Product: Vinflunine 162652-95-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%-99%
Supply Ability: 2000kg
Release date: 2019-08-05

162652-95-1, VinflunineRelated Search:

(R)-3-AMINO-4-(3-METHYLPHENYL)BUTANOIC ACID HYDROCHLORIDE 2,4-Dipentylphenol 3-AMINO-4-(4-METHOXY-PHENYL)-BUTYRIC ACID 2-TERT-BUTYL-1H-INDOLE 4-PHENYLCYCLOHEXANOL α-(p-Aminophenyl)butyric acid (2S)-2,3-Dihydroxy-2-methyl-propanoic Acid Methyl Ester 90% TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID 4-AMINOCYCLOHEXANECARBOXYLIC ACID (R)-(-)-2-HYDROXY-4-PHENYLBUTYRIC ACID Vinflunine INDOLE-2-ACETIC ACID 3,3,5,5-TETRAMETHYLCYCLOHEXANOL 1-HYDROXY-CYCLOHEXANECARBOXYLIC ACID L-LEUCIC ACID (2-METHOXY-5-METHYLPHENYL)ACETIC ACID 3-PHENETHYL-PIPERIDINE (2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRIC ACID HYDROCHLORIDE

VINFLUNINE

Vinflunine 162652-95-1

20',20'-Difluoro-3',4'-dihydrovinorelbine

4'-Deoxy-20',20'-difluoro-5'-norvincaleukoblastine

4'-Deoxy-20',20'-difluoro-8'-norvincaleukoblastine

Vinflunine Tartrate

Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-

Vinflunine USP/EP/BP

Vinflunine (F12158)

Aspidospermidine-3-carboxylicacid,4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-1

vinflunine（97%）

162652-95-1

C45H54F2N4O8

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