TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID

Product Name: TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID
CAS No.: 3685-25-4
Chemical Name: TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID
Synonyms: 4-azanylcyclohexane-1-carboxylic acid;4α-Amino-1β-cyclohexanecarboxylic acid;(1α)-4β-Aminocyclohexanecarboxylic acid;TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID;trans-4-Aminocyclohexanecarboxylic ccid;trans-4-Aminocyclohexyl carboxylic acid;trans-4-AminocyclohexanecarboxylicAcid>trans-4-Aminocyclohexane-1-carboxylic acid;Cyclohexanecarboxylic acid, 4-aMino-, trans-;trans-4-Aminocyclohexanecarboxylic Acid
CBNumber: CB9104974
Molecular Formula: C7H13NO2
Formula Weight: 143.18
MOL File: 3685-25-4.mol

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TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID Property

Melting point:: 495 °C
Boiling point:: 56-58 °C(Press: 0.08 Torr)
Density: 1.133±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
Water Solubility: Soluble in water
form: powder to crystal
pka: 4.46±0.10(Predicted)
color: White to Almost white
InChI: InChI=1S/C7H13NO2/c8-6-3-1-5(2-4-6)7(9)10/h5-6H,1-4,8H2,(H,9,10)/t5-,6-
InChIKey: DRNGLYHKYPNTEA-IZLXSQMJSA-N
SMILES: [C@@H]1(C(O)=O)CC[C@@H](N)CC1

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Safety

Safety Statements: 24/25
Hazard Note: Irritant
HS Code: 29159000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A1656
Product name: trans-4-Aminocyclohexanecarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $65
Updated: 2025/07/31

TCI Chemical

Product number: A1656
Product name: trans-4-Aminocyclohexanecarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $212
Updated: 2025/07/31

TCI Chemical

Product number: A1656
Product name: trans-4-Aminocyclohexanecarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $736
Updated: 2025/07/31

TRC

Product number: A615703
Product name: trans-4-Aminocyclohexanecarboxylic Acid
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FT139212
Product name: trans-4-Aminocyclohexanecarboxylic ccid
Packaging: 2g
Price: $65
Updated: 2021/12/16

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TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

The trans-4-Aminocyclohexanecarboxylic acid derivative is a useful building block for the synthesis of a variety of pharmacologically active compounds such as glimepiride (L-370518).

Synthesis

150-13-0

1776-53-0

3685-23-2

The general procedure for the synthesis of 4-aminocyclohexanecarboxylic acid and cis-4-aminocyclohexanecarboxylic acid from p-aminobenzoic acid is as follows: p-aminobenzoic acid (10.0 g, 0.07 mol, 1 equiv.), 5% Ru/C catalyst (2.50 g), and 10% NaOH solution (100.0 mL) were added in an autoclave. The mixture was subjected to 100 bar hydrogen pressure and the reaction was stirred in a 15 bar hydrogen atmosphere. After 20 h of reaction, the progress of the reaction was monitored by thin layer chromatography (TLC) with DCM/MeOH/NH3 (5:5:1, v/v/v) as the unfolding agent and ninhydrin as the color developer to confirm the complete consumption of the starting material. Nuclear magnetic resonance (NMR) analysis showed that the reaction was fully converted and the ratio of cis to trans product was 1:4.6. The reaction was terminated.

References

[1] European Journal of Medicinal Chemistry, 2001, vol. 36, # 3, p. 265 - 286
[2] Biochemische Zeitschrift, 1933, vol. 262, p. 462
[3] Journal of the American Chemical Society, 1938, vol. 60, p. 2341,2343
[4] Chemische Berichte, 1942, vol. 75, p. 425,428
[5] Chemische Berichte, 1943, vol. 76, p. 1019,1023

TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID Suppliers

Americas 1 Belgium 1 China 154 Europe 1 France 2 Germany 5 India 10 Japan 4 United Kingdom 5 United States 35 Global 218

Beijing Advanced Technology Co., Ltd.

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Capot Chemical Co., Ltd

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View Lastest Price from TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 4-Aminocyclohexanecarboxylic acid 3685-25-4
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-24

Shaanxi Dideu Medichem Co. Ltd

Product: TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID 3685-25-4
Price: US $1.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-19

Zhuozhou Wenxi import and Export Co., Ltd

Product: TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID 3685-25-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

3685-25-4, TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACIDRelated Search:

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(1α)-4β-Aminocyclohexanecarboxylic acid

4α-Amino-1β-cyclohexanecarboxylic acid

4-azanylcyclohexane-1-carboxylic acid

rel-(1R,4R)-4-aMinocyclohexane-1-carboxylic acid

Cyclohexanecarboxylic acid, 4-aMino-, trans-

TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID

<i>trans</i>-4-Aminocyclohexanecarboxylic Acid

trans-4-Aminocyclohexane-1-carboxylic acid

trans-4-Aminocyclohexanecarboxylic ccid

trans-4-AminocyclohexanecarboxylicAcid&gt

trans-4-Aminocyclohexyl carboxylic acid

trans-4-Amino-cyclohexanecarboxylic acid, CAS 3685-25-4

3685-25-4

4-Substituted Cyclohexanecarboxylic Acids