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trans-4-Dimethylaminocrotonic acid hydrochloride

Product Name
trans-4-Dimethylaminocrotonic acid hydrochloride
CAS No.
848133-35-7
Chemical Name
trans-4-Dimethylaminocrotonic acid hydrochloride
Synonyms
(E)-4-(dimethylamino)but-2-enoic acid hydrochloride;(e)-4-(dimethylamino)-2-butenoic acid hydrochloride;THRX-196194;Afatinib intermediate E;trans-4-Dimethylaminocrotonic;(E)-4-(Dimethylamino)-2-buteno;TRANS-4-DIMETHYLAMINOCROTONIC ACID HCL;(E)-4-(DIMETHYLAMINO)BUT-2-ENOIC ACID HCL;4-DiMethylaMino-But-2-Enoic Acid Hcl Salt;(2E)-4-(Dimethylamino)but-2-enoic acid HCl
CBNumber
CB8854829
Molecular Formula
C6H12ClNO2
Formula Weight
165.62
MOL File
848133-35-7.mol
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trans-4-Dimethylaminocrotonic acid hydrochloride Property

Melting point:
162 °C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
Solid
color 
White to Off-White
InChI
InChI=1S/C6H11NO2.ClH/c1-7(2)5-3-4-6(8)9;/h3-4H,5H2,1-2H3,(H,8,9);1H/b4-3+;
InChIKey
UUHNQHFOIVLAQX-BJILWQEISA-N
SMILES
C(/CN(C)C)=C\C(=O)O.Cl
CAS DataBase Reference
848133-35-7(CAS DataBase Reference)
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Safety

HS Code 
2922498590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D5625
Product name
(E)-4-(Dimethylamino)-2-butenoic Acid Hydrochloride
Packaging
1G
Price
$52
Updated
2024/03/01
TCI Chemical
Product number
D5625
Product name
(E)-4-(Dimethylamino)-2-butenoic Acid Hydrochloride
Packaging
5G
Price
$180
Updated
2024/03/01
TRC
Product number
D446630
Product name
trans4-DimethylaminocrotonicAcidHydrochloride
Packaging
2g
Price
$180
Updated
2021/12/16
TRC
Product number
D446630
Product name
trans4-DimethylaminocrotonicAcidHydrochloride
Packaging
2.5g
Price
$225
Updated
2021/12/16
ChemScene
Product number
CS-D1794
Product name
(E)-4-(Dimethylamino)-2-butenoic Acid Hydrochloride
Purity
98.00%
Packaging
10g
Price
$36
Updated
2021/12/16
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trans-4-Dimethylaminocrotonic acid hydrochloride Chemical Properties,Usage,Production

Description

trans-4-Dimethylaminocrotonic acid hydrochloride is a very important pharmaceutical intermediate and is an essential part of the structure of the anti-tumour drugs afatinib and neratinib. It is also an important organic synthesis reagent for the preparation of novel pyrazole derivatives and 6-heterocycloalkyl quinazoline derivatives.

Chemical Properties

White Solid

Uses

trans 4-Dimethylaminocrotonic acid HCl is a reagent used in the preparation of tyrosine kinase inhibiting antitumor agents.

Synthesis

trans-4-Dimethylaminocrotonic acid hydrochloride is synthesised using (E)-4-(dimethylamino)-2-butenoic acid methyl ester as a raw material by adding reagents such as water, sodium hydroxide, methanol, and hydrogen chloride through a chemical reaction.

trans-4-Dimethylaminocrotonic acid hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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trans-4-Dimethylaminocrotonic acid hydrochloride Suppliers

Jinan XuanDe Chemical Co., Ltd.
Tel
0531-88803958; 18866891188
Fax
0531-82777287
Email
zhaojiangxia@shiningpharm.com
Country
China
ProdList
275
Advantage
58
Sichuan Hainuowei Technology Co. Ltd.
Tel
13708085536
Fax
QQ : 121102042
Email
hanovichem@163.com
Country
China
ProdList
3383
Advantage
56
Established by Hangzhou Boman Biochem Tech Co., Ltd
Tel
13588048971 13588048971
Email
sales@bomanbiochem.com
Country
China
ProdList
409
Advantage
58
FarmaSino Pharmaceuticals (Jiangsu) Co.,Ltd
Tel
15756008279
Email
mqm@farmasino.com
Country
China
ProdList
129
Advantage
58
Mianyang Vandino Pharmaceutical Technology Co., Ltd.
Tel
0816-1568120-1579 15681201579
Fax
15281123955
Email
1755695756@qq.com
Country
China
ProdList
308
Advantage
58
TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.
Tel
022-60182192,1339732154 18722583064
Fax
86-22-60979672
Email
marketing@pharmacn.com
Country
China
ProdList
112
Advantage
61
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
4986
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.
Tel
0311-89250318 031166536426
Fax
4000311741
Email
master@sjzsdyn.com
Country
China
ProdList
2964
Advantage
65
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View Lastest Price from trans-4-Dimethylaminocrotonic acid hydrochloride manufacturers

Nanjing Fred Technology Co., Ltd
Product
trans-4-dimethylaminocrotonic acid hydrochloride 848133-35-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-20
hebei hongtan Biotechnology Co., Ltd
Product
trans-4-Dimethylaminocrotonic acid hydrochloride 848133-35-7
Price
US $30.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000kg
Release date
2024-05-16
Jinan Finer Chemical Co., Ltd
Product
trans-4-Dimethylaminocrotonic acid hydrochloride 848133-35-7
Price
US $0.00/Kg/Drum
Min. Order
1g
Purity
99%
Supply Ability
100mt/year
Release date
2021-09-23

848133-35-7, trans-4-Dimethylaminocrotonic acid hydrochlorideRelated Search:


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