trans-4-Dimethylaminocrotonic acid hydrochloride

Product Name: trans-4-Dimethylaminocrotonic acid hydrochloride
CAS No.: 848133-35-7
Chemical Name: trans-4-Dimethylaminocrotonic acid hydrochloride
Synonyms: (E)-4-(dimethylamino)but-2-enoic acid hydrochloride;(e)-4-(dimethylamino)-2-butenoic acid hydrochloride;THRX-196194;Afatinib intermediate E;trans-4-Dimethylaminocrotonic;(E)-4-(Dimethylamino)-2-buteno;TRANS-4-DIMETHYLAMINOCROTONIC ACID HCL;(E)-4-(DIMETHYLAMINO)BUT-2-ENOIC ACID HCL;4-DiMethylaMino-But-2-Enoic Acid Hcl Salt;(2E)-4-(Dimethylamino)but-2-enoic acid HCl
CBNumber: CB8854829
Molecular Formula: C6H12ClNO2
Formula Weight: 165.62
MOL File: 848133-35-7.mol

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trans-4-Dimethylaminocrotonic acid hydrochloride Property

Melting point:: 162 °C
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: Solid
color: White to Off-White
InChI: InChI=1S/C6H11NO2.ClH/c1-7(2)5-3-4-6(8)9;/h3-4H,5H2,1-2H3,(H,8,9);1H/b4-3+;
InChIKey: UUHNQHFOIVLAQX-BJILWQEISA-N
SMILES: C(/CN(C)C)=C\C(=O)O.Cl
CAS DataBase Reference: 848133-35-7(CAS DataBase Reference)

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Safety

HS Code: 2922498590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D5625
Product name: (E)-4-(Dimethylamino)-2-butenoic Acid Hydrochloride
Packaging: 1G
Price: $47
Updated: 2025/07/31

TCI Chemical

Product number: D5625
Product name: (E)-4-(Dimethylamino)-2-butenoic Acid Hydrochloride
Packaging: 5G
Price: $162
Updated: 2025/07/31

TRC

Product number: D446630
Product name: trans4-DimethylaminocrotonicAcidHydrochloride
Packaging: 2g
Price: $180
Updated: 2021/12/16

TRC

Product number: D446630
Product name: trans4-DimethylaminocrotonicAcidHydrochloride
Packaging: 2.5g
Price: $225
Updated: 2021/12/16

ChemScene

Product number: CS-D1794
Product name: (E)-4-(Dimethylamino)-2-butenoic Acid Hydrochloride
Purity: 98.00%
Packaging: 10g
Price: $36
Updated: 2021/12/16

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trans-4-Dimethylaminocrotonic acid hydrochloride Chemical Properties,Usage,Production

Description

trans-4-Dimethylaminocrotonic acid hydrochloride is a very important pharmaceutical intermediate and is an essential part of the structure of the anti-tumour drugs afatinib and neratinib. It is also an important organic synthesis reagent for the preparation of novel pyrazole derivatives and 6-heterocycloalkyl quinazoline derivatives.

Chemical Properties

White Solid

Uses

trans 4-Dimethylaminocrotonic acid HCl is a reagent used in the preparation of tyrosine kinase inhibiting antitumor agents.

Synthesis

trans-4-Dimethylaminocrotonic acid hydrochloride is synthesised using (E)-4-(dimethylamino)-2-butenoic acid methyl ester as a raw material by adding reagents such as water, sodium hydroxide, methanol, and hydrogen chloride through a chemical reaction.

trans-4-Dimethylaminocrotonic acid hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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trans-4-Dimethylaminocrotonic acid hydrochloride Suppliers

Americas 1 Canada 1 China 352 Europe 1 Germany 1 India 9 Japan 1 United Kingdom 3 United States 16 Global 385

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Energy Chemical

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Shijiazhuang Sdyano Fine Chemical Co., Ltd.

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Wuhan Chemwish Technology Co., Ltd

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JinYan Chemicals(ShangHai) Co.,Ltd.

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View Lastest Price from trans-4-Dimethylaminocrotonic acid hydrochloride manufacturers

Jinan Finer Chemical Co., Ltd

Product: trans-4-Dimethylaminocrotonic acid hydrochloride 848133-35-7
Price: US $0.00/Kg/Drum
Min. Order: 1g
Purity: 99%
Supply Ability: 100mt/year
Release date: 2021-09-23

Henan Aochuang Chemical Co.,Ltd.

Product: trans-4-Dimethylaminocrotonic acid hydrochloride 848133-35-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Nanjing Fred Technology Co., Ltd

Product: trans-4-dimethylaminocrotonic acid hydrochloride 848133-35-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-20

848133-35-7, trans-4-Dimethylaminocrotonic acid hydrochlorideRelated Search:

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2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride

Afatinib int-2 Trans-4-Dimethylaminocrotonic acid hydrochloride

2-Butenoic acid, 4-(dimethylamino)-, (2E)-, hydrochloride

trans-4-Dimethylaminocrotonic acid hydrochloride, >=97%

trans-4-Dimethylaminocrotonic

trans-4-dimethylaminocrotonic acid hydrochloride salt

2-Butenoic acid,4-(dimethylamino)-, hydrochloride (1:1), (2E)-

trans-4-Dimethylaminocrotonic acid hydrochloride(848133-35-7)

(E)-4-(DIMETHYLAMINO)BUT-2-ENOIC ACID HCL

(e)-4-(dimethylamino)-2-butenoic acid hydrochloride

4-DiMethylaMino-But-2-Enoic Acid Hcl Salt

trans-4-Dimethylaminocrotonic acid hydrochloride

TRANS-4-DIMETHYLAMINOCROTONIC ACID HCL

2-BUTENOIC ACID, 4-(DIMETHYLAMINO)-, HYDROCHLORIDE

(E)-4-(dimethylamino)but-2-enoic acid hydrochloride

Afatinib intermediate E

(2E)-4-(diMethylaMino)but-2-enoic acid hydrochloride

trans-4-(DiMethylaMino)-2-butenoic Acid Hydrochloride

trans-4-Dimethylaminocrotonic acid hydrochloride (E)-4-(Dimethylamino)-2-butenoic acid hydrochloride

(2E)-4-(dimethylamino)but-2-enoic acid hydrochloride, trans

2-Butenoic acid, 4-(dimethylamino)-, hydrochloride (1:1)

(2E)-4-(Dimethylamino)but-2-enoic acid?hydrochloride (1:1)

(E)-4-Dimethylaminocrotonic Acid Hydrochloride

trans-4-Dimethylaminocrotonic acid hydrochloride ISO 9001：2015 REACH

THRX-196194

(E)-4-(Dimethylamino)-2-buteno

(2E)-4-(dimethylamino)-2-Butenoic acid hydrochloride (1:1)

(2E)-4-(Dimethylamino)but-2-enoic acid HCl

trans-4-Dimethylaminocrotonic acid hydrochloride，(E)-4-(Dimethylamino)But-2-Enoic Acid Hydrochloride

848133-35-7Trans-4-dimethylaminocrotonicacidhydrochloride

trans-4-Dimethylaminocrotonic acid HCl 98%

848133-35-7

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