trans-4-Dimethylaminocrotonic acid hydrochloride
- Product Name
- trans-4-Dimethylaminocrotonic acid hydrochloride
- CAS No.
- 848133-35-7
- Chemical Name
- trans-4-Dimethylaminocrotonic acid hydrochloride
- Synonyms
- (E)-4-(dimethylamino)but-2-enoic acid hydrochloride;(e)-4-(dimethylamino)-2-butenoic acid hydrochloride;THRX-196194;Afatinib intermediate E;trans-4-Dimethylaminocrotonic;(E)-4-(Dimethylamino)-2-buteno;TRANS-4-DIMETHYLAMINOCROTONIC ACID HCL;(E)-4-(DIMETHYLAMINO)BUT-2-ENOIC ACID HCL;4-DiMethylaMino-But-2-Enoic Acid Hcl Salt;(2E)-4-(Dimethylamino)but-2-enoic acid HCl
- CBNumber
- CB8854829
- Molecular Formula
- C6H12ClNO2
- Formula Weight
- 165.62
- MOL File
- 848133-35-7.mol
trans-4-Dimethylaminocrotonic acid hydrochloride Property
- Melting point:
- 162 °C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C6H11NO2.ClH/c1-7(2)5-3-4-6(8)9;/h3-4H,5H2,1-2H3,(H,8,9);1H/b4-3+;
- InChIKey
- UUHNQHFOIVLAQX-BJILWQEISA-N
- SMILES
- C(/CN(C)C)=C\C(=O)O.Cl
- CAS DataBase Reference
- 848133-35-7(CAS DataBase Reference)
Safety
- HS Code
- 2922498590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D5625
- Product name
- (E)-4-(Dimethylamino)-2-butenoic Acid Hydrochloride
- Packaging
- 1G
- Price
- $52
- Updated
- 2024/03/01
- Product number
- D5625
- Product name
- (E)-4-(Dimethylamino)-2-butenoic Acid Hydrochloride
- Packaging
- 5G
- Price
- $180
- Updated
- 2024/03/01
- Product number
- D446630
- Product name
- trans4-DimethylaminocrotonicAcidHydrochloride
- Packaging
- 2.5g
- Price
- $225
- Updated
- 2021/12/16
- Product number
- D446630
- Product name
- trans4-DimethylaminocrotonicAcidHydrochloride
- Packaging
- 2g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 4358-5-32
- Product name
- trans-4-(Dimethylamino)-2-butenoic acid hydrochloride
- Packaging
- 25g
- Price
- $266
- Updated
- 2021/12/16
trans-4-Dimethylaminocrotonic acid hydrochloride Chemical Properties,Usage,Production
Description
trans-4-Dimethylaminocrotonic acid hydrochloride is a very important pharmaceutical intermediate and is an essential part of the structure of the anti-tumour drugs afatinib and neratinib. It is also an important organic synthesis reagent for the preparation of novel pyrazole derivatives and 6-heterocycloalkyl quinazoline derivatives.
Chemical Properties
White Solid
Uses
trans 4-Dimethylaminocrotonic acid HCl is a reagent used in the preparation of tyrosine kinase inhibiting antitumor agents.
Synthesis
trans-4-Dimethylaminocrotonic acid hydrochloride is synthesised using (E)-4-(dimethylamino)-2-butenoic acid methyl ester as a raw material by adding reagents such as water, sodium hydroxide, methanol, and hydrogen chloride through a chemical reaction.
trans-4-Dimethylaminocrotonic acid hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from trans-4-Dimethylaminocrotonic acid hydrochloride manufacturers
- Product
- trans-4-dimethylaminocrotonic acid hydrochloride 848133-35-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-20
- Product
- trans-4-Dimethylaminocrotonic acid hydrochloride 848133-35-7
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 2000kg
- Release date
- 2024-05-16
- Product
- trans-4-Dimethylaminocrotonic acid hydrochloride 848133-35-7
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100mt/year
- Release date
- 2021-09-23