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trans-4-Dimethylaminocrotonic acid hydrochloride

Product Name
trans-4-Dimethylaminocrotonic acid hydrochloride
CAS No.
848133-35-7
Chemical Name
trans-4-Dimethylaminocrotonic acid hydrochloride
Synonyms
(E)-4-(dimethylamino)but-2-enoic acid hydrochloride;(e)-4-(dimethylamino)-2-butenoic acid hydrochloride;THRX-196194;Afatinib intermediate E;trans-4-Dimethylaminocrotonic;(E)-4-(Dimethylamino)-2-buteno;TRANS-4-DIMETHYLAMINOCROTONIC ACID HCL;(E)-4-(DIMETHYLAMINO)BUT-2-ENOIC ACID HCL;4-DiMethylaMino-But-2-Enoic Acid Hcl Salt;(2E)-4-(Dimethylamino)but-2-enoic acid HCl
CBNumber
CB8854829
Molecular Formula
C6H12ClNO2
Formula Weight
165.62
MOL File
848133-35-7.mol
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trans-4-Dimethylaminocrotonic acid hydrochloride Property

Melting point:
162 °C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
Solid
color 
White to Off-White
InChI
InChI=1S/C6H11NO2.ClH/c1-7(2)5-3-4-6(8)9;/h3-4H,5H2,1-2H3,(H,8,9);1H/b4-3+;
InChIKey
UUHNQHFOIVLAQX-BJILWQEISA-N
SMILES
C(/CN(C)C)=C\C(=O)O.Cl
CAS DataBase Reference
848133-35-7(CAS DataBase Reference)
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Safety

HS Code 
2922498590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D5625
Product name
(E)-4-(Dimethylamino)-2-butenoic Acid Hydrochloride
Packaging
1G
Price
$52
Updated
2024/03/01
TCI Chemical
Product number
D5625
Product name
(E)-4-(Dimethylamino)-2-butenoic Acid Hydrochloride
Packaging
5G
Price
$180
Updated
2024/03/01
TRC
Product number
D446630
Product name
trans4-DimethylaminocrotonicAcidHydrochloride
Packaging
2.5g
Price
$225
Updated
2021/12/16
TRC
Product number
D446630
Product name
trans4-DimethylaminocrotonicAcidHydrochloride
Packaging
2g
Price
$180
Updated
2021/12/16
SynQuest Laboratories
Product number
4358-5-32
Product name
trans-4-(Dimethylamino)-2-butenoic acid hydrochloride
Packaging
25g
Price
$266
Updated
2021/12/16
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trans-4-Dimethylaminocrotonic acid hydrochloride Chemical Properties,Usage,Production

Description

trans-4-Dimethylaminocrotonic acid hydrochloride is a very important pharmaceutical intermediate and is an essential part of the structure of the anti-tumour drugs afatinib and neratinib. It is also an important organic synthesis reagent for the preparation of novel pyrazole derivatives and 6-heterocycloalkyl quinazoline derivatives.

Chemical Properties

White Solid

Uses

trans 4-Dimethylaminocrotonic acid HCl is a reagent used in the preparation of tyrosine kinase inhibiting antitumor agents.

Synthesis

trans-4-Dimethylaminocrotonic acid hydrochloride is synthesised using (E)-4-(dimethylamino)-2-butenoic acid methyl ester as a raw material by adding reagents such as water, sodium hydroxide, methanol, and hydrogen chloride through a chemical reaction.

trans-4-Dimethylaminocrotonic acid hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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trans-4-Dimethylaminocrotonic acid hydrochloride Suppliers

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View Lastest Price from trans-4-Dimethylaminocrotonic acid hydrochloride manufacturers

Nanjing Fred Technology Co., Ltd
Product
trans-4-dimethylaminocrotonic acid hydrochloride 848133-35-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-20
hebei hongtan Biotechnology Co., Ltd
Product
trans-4-Dimethylaminocrotonic acid hydrochloride 848133-35-7
Price
US $30.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000kg
Release date
2024-05-16
Jinan Finer Chemical Co., Ltd
Product
trans-4-Dimethylaminocrotonic acid hydrochloride 848133-35-7
Price
US $0.00/Kg/Drum
Min. Order
1g
Purity
99%
Supply Ability
100mt/year
Release date
2021-09-23

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  • 2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride
  • Afatinib int-2 Trans-4-Dimethylaminocrotonic acid hydrochloride
  • 2-Butenoic acid, 4-(dimethylamino)-, (2E)-, hydrochloride
  • trans-4-Dimethylaminocrotonic acid hydrochloride, >=97%
  • trans-4-Dimethylaminocrotonic
  • trans-4-dimethylaminocrotonic acid hydrochloride salt
  • 2-Butenoic acid,4-(dimethylamino)-, hydrochloride (1:1), (2E)-
  • trans-4-Dimethylaminocrotonic acid hydrochloride(848133-35-7)
  • (E)-4-(DIMETHYLAMINO)BUT-2-ENOIC ACID HCL
  • (e)-4-(dimethylamino)-2-butenoic acid hydrochloride
  • 4-DiMethylaMino-But-2-Enoic Acid Hcl Salt
  • trans-4-Dimethylaminocrotonic acid hydrochloride
  • TRANS-4-DIMETHYLAMINOCROTONIC ACID HCL
  • 2-BUTENOIC ACID, 4-(DIMETHYLAMINO)-, HYDROCHLORIDE
  • (E)-4-(dimethylamino)but-2-enoic acid hydrochloride
  • Afatinib intermediate E
  • (2E)-4-(diMethylaMino)but-2-enoic acid hydrochloride
  • trans-4-(DiMethylaMino)-2-butenoic Acid Hydrochloride
  • trans-4-Dimethylaminocrotonic acid hydrochloride (E)-4-(Dimethylamino)-2-butenoic acid hydrochloride
  • (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride, trans
  • 2-Butenoic acid, 4-(dimethylamino)-, hydrochloride (1:1)
  • (2E)-4-(Dimethylamino)but-2-enoic acid?hydrochloride (1:1)
  • (E)-4-Dimethylaminocrotonic Acid Hydrochloride
  • trans-4-Dimethylaminocrotonic acid hydrochloride ISO 9001：2015 REACH
  • THRX-196194
  • (E)-4-(Dimethylamino)-2-buteno
  • (2E)-4-(dimethylamino)-2-Butenoic acid hydrochloride (1:1)
  • (2E)-4-(Dimethylamino)but-2-enoic acid HCl
  • trans-4-Dimethylaminocrotonic acid hydrochloride，(E)-4-(Dimethylamino)But-2-Enoic Acid Hydrochloride
  • 848133-35-7
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  • 848133-35-7