ChemicalBook > CAS DataBase List > trans-4-Dimethylaminocrotonic acid hydrochloride

trans-4-Dimethylaminocrotonic acid hydrochloride

Product Name
trans-4-Dimethylaminocrotonic acid hydrochloride
CAS No.
848133-35-7
Chemical Name
trans-4-Dimethylaminocrotonic acid hydrochloride
Synonyms
(E)-4-(dimethylamino)but-2-enoic acid hydrochloride;(e)-4-(dimethylamino)-2-butenoic acid hydrochloride;THRX-196194;Afatinib intermediate E;trans-4-Dimethylaminocrotonic;(E)-4-(Dimethylamino)-2-buteno;TRANS-4-DIMETHYLAMINOCROTONIC ACID HCL;(E)-4-(DIMETHYLAMINO)BUT-2-ENOIC ACID HCL;4-DiMethylaMino-But-2-Enoic Acid Hcl Salt;(2E)-4-(Dimethylamino)but-2-enoic acid HCl
CBNumber
CB8854829
Molecular Formula
C6H12ClNO2
Formula Weight
165.62
MOL File
848133-35-7.mol
More
Less

trans-4-Dimethylaminocrotonic acid hydrochloride Property

Melting point:
162 °C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
Solid
color 
White to Off-White
InChI
InChI=1S/C6H11NO2.ClH/c1-7(2)5-3-4-6(8)9;/h3-4H,5H2,1-2H3,(H,8,9);1H/b4-3+;
InChIKey
UUHNQHFOIVLAQX-BJILWQEISA-N
SMILES
C(/CN(C)C)=C\C(=O)O.Cl
CAS DataBase Reference
848133-35-7(CAS DataBase Reference)
More
Less

Safety

HS Code 
2922498590
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
D5625
Product name
(E)-4-(Dimethylamino)-2-butenoic Acid Hydrochloride
Packaging
1G
Price
$52
Updated
2024/03/01
TCI Chemical
Product number
D5625
Product name
(E)-4-(Dimethylamino)-2-butenoic Acid Hydrochloride
Packaging
5G
Price
$180
Updated
2024/03/01
TRC
Product number
D446630
Product name
trans4-DimethylaminocrotonicAcidHydrochloride
Packaging
2.5g
Price
$225
Updated
2021/12/16
TRC
Product number
D446630
Product name
trans4-DimethylaminocrotonicAcidHydrochloride
Packaging
2g
Price
$180
Updated
2021/12/16
SynQuest Laboratories
Product number
4358-5-32
Product name
trans-4-(Dimethylamino)-2-butenoic acid hydrochloride
Packaging
25g
Price
$266
Updated
2021/12/16
More
Less

trans-4-Dimethylaminocrotonic acid hydrochloride Chemical Properties,Usage,Production

Description

trans-4-Dimethylaminocrotonic acid hydrochloride is a very important pharmaceutical intermediate and is an essential part of the structure of the anti-tumour drugs afatinib and neratinib. It is also an important organic synthesis reagent for the preparation of novel pyrazole derivatives and 6-heterocycloalkyl quinazoline derivatives.

Chemical Properties

White Solid

Uses

trans 4-Dimethylaminocrotonic acid HCl is a reagent used in the preparation of tyrosine kinase inhibiting antitumor agents.

Synthesis

trans-4-Dimethylaminocrotonic acid hydrochloride is synthesised using (E)-4-(dimethylamino)-2-butenoic acid methyl ester as a raw material by adding reagents such as water, sodium hydroxide, methanol, and hydrogen chloride through a chemical reaction.

trans-4-Dimethylaminocrotonic acid hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

trans-4-Dimethylaminocrotonic acid hydrochloride Suppliers

Jinan XuanDe Chemical Co., Ltd.
Tel
0531-88803958; 18866891188
Fax
0531-82777287
Email
zhaojiangxia@shiningpharm.com
Country
China
ProdList
275
Advantage
58
Sichuan Hainuowei Technology Co. Ltd.
Tel
13708085536
Fax
QQ : 121102042
Email
hanovichem@163.com
Country
China
ProdList
3383
Advantage
56
Established by Hangzhou Boman Biochem Tech Co., Ltd
Tel
13588048971 13588048971
Email
sales@bomanbiochem.com
Country
China
ProdList
410
Advantage
58
FarmaSino Pharmaceuticals (Jiangsu) Co.,Ltd
Tel
25-8690-7345 18651693585
Email
zfx@farmasino.com
Country
China
ProdList
129
Advantage
58
Mianyang Vandino Pharmaceutical Technology Co., Ltd.
Tel
0816-1568120-1579 15681201579
Fax
15281123955
Email
1755695756@qq.com
Country
China
ProdList
309
Advantage
58
JIANGXI HANHE PHARMACEUTICAL CO.,LTD
Tel
18721221949
Email
zhangle@jxhhzy.com
Country
China
ProdList
49
Advantage
58
TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.
Tel
022-60182192,1339732154 18722583064
Fax
86-22-60979672
Email
marketing@pharmacn.com
Country
China
ProdList
112
Advantage
61
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
4986
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.
Tel
0311-89250318 031166536426
Fax
4000311741
Email
master@sjzsdyn.com
Country
China
ProdList
2963
Advantage
65
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9413
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11655
Advantage
64
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19172
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8843
Advantage
52
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4552
Advantage
62
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4378
Advantage
65
Aemon Chemical
Tel
0086-755-86198205
Email
acinfo@aemonchem.com
Country
China
ProdList
1931
Advantage
57
Shanghai Sphchem Co., Ltd.
Tel
21-21-56491756 13512199871
Fax
021-5649-1756
Email
sales@panhongchem.com
Country
China
ProdList
4000
Advantage
55
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2871
Advantage
58
Wuhan Haizheng Industry & Trade Development Co. Ltd
Tel
027-8866 0053/88660577/88660578
Fax
027-8899 1911
Country
China
ProdList
1073
Advantage
55
Wisdom Pharmaceutical Co., Ltd.
Tel
0086-15189180296
Fax
0086-513-81292226
Email
l_xu@wisdompharma.com
Country
China
ProdList
221
Advantage
60
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4940
Advantage
60
Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.
Tel
022-60116533 13207668525
Fax
022-60979672
Email
saleskc@scipharmacn.com
Country
China
ProdList
683
Advantage
58
Suzhou Sibian Chemical Technology Co.,Ltd.
Tel
0512-65617459 18915409046
Fax
0512-65617459
Email
sales@sibian-chem.com
Country
China
ProdList
1922
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9459
Advantage
58
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
18017383231 18017383231
Fax
qq:2817624287
Email
lyh_antaeus@163.com
Country
China
ProdList
9347
Advantage
55
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.
Tel
021-34666753 13311639313
Fax
+86-21-34979012
Email
info@shyrchem.com
Country
China
ProdList
571
Advantage
55
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9545
Advantage
55
Shanghai Arbor Chemical Co., Ltd.
Tel
021-60451683 15021268886
Fax
+86-21-60451682
Email
sales@arborchemical.com
Country
China
ProdList
853
Advantage
55
China Nobel Chem Co., Limited
Tel
+86(0)21 60484900
Fax
+86(0)21 60484900
Country
China
ProdList
764
Advantage
50
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Shanghai Synmedia Chemical Co., Ltd.
Tel
021-38681880 13817889927
Fax
0213390-8196
Email
sales@synmedia-chem.com
Country
China
ProdList
249
Advantage
58
Shanghai sinco chem Co.,Ltd.
Tel
021-62986072
Email
sincochem@163.com
Country
China
ProdList
11
Advantage
55
Shanghai Hekang Biotechnology Co., Ltd.
Tel
18939837085
Fax
2880152141(QQ)
Email
youchemicals@gmail.com
Country
China
ProdList
1830
Advantage
55
Nanjing Credit Trading Co.,Ltd
Tel
025-52164950
Fax
025-86800069
Email
Googlexu_0114@sina.com
Country
China
ProdList
644
Advantage
58
3B Scientific (Wuhan) Corporation Limited
Tel
0086-27-88063677 18186135292
Fax
027-88063656
Email
sales@3bsc.com
Country
China
ProdList
292
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Porse Fine Chemical Co.,LTD
Tel
20-66003216 18666003216
Fax
+86-20-28069063
Email
info@porsefinechemical.com
Country
China
ProdList
2353
Advantage
62
Nanjing First Pharmaceutical Co., Ltd.
Tel
025-83172655 13585105703
Fax
+86-25-86501191
Email
sales@njfirstpharm.com
Country
China
ProdList
110
Advantage
60
Chongqing Xingcan Pharmaceutical Technology Co., Ltd.
Tel
15523000485
Email
xingcanyaoye@sina.com
Country
China
ProdList
1686
Advantage
58
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Chemfun Medical Technology(Shanghai) Co., Ltd.
Tel
021-67220633 021-54824098
Fax
+86-21-54824069
Email
chemfun@chemfun.net
Country
China
ProdList
491
Advantage
58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883 15367835770
Fax
0731-82251112
Email
viola@huatengsci.com
Country
China
ProdList
5875
Advantage
58
Shanghai SE Pharm Co., Ltd
Tel
18112588827
Email
sales4@sepharm.com.cn
Country
China
ProdList
300
Advantage
60
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10276
Advantage
55
More
Less

View Lastest Price from trans-4-Dimethylaminocrotonic acid hydrochloride manufacturers

Nanjing Fred Technology Co., Ltd
Product
trans-4-dimethylaminocrotonic acid hydrochloride 848133-35-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-20
hebei hongtan Biotechnology Co., Ltd
Product
trans-4-Dimethylaminocrotonic acid hydrochloride 848133-35-7
Price
US $30.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000kg
Release date
2024-05-16
Jinan Finer Chemical Co., Ltd
Product
trans-4-Dimethylaminocrotonic acid hydrochloride 848133-35-7
Price
US $0.00/Kg/Drum
Min. Order
1g
Purity
99%
Supply Ability
100mt/year
Release date
2021-09-23

848133-35-7, trans-4-Dimethylaminocrotonic acid hydrochlorideRelated Search:


  • 2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride
  • Afatinib int-2 Trans-4-Dimethylaminocrotonic acid hydrochloride
  • 2-Butenoic acid, 4-(dimethylamino)-, (2E)-, hydrochloride
  • trans-4-Dimethylaminocrotonic acid hydrochloride, >=97%
  • trans-4-Dimethylaminocrotonic
  • trans-4-dimethylaminocrotonic acid hydrochloride salt
  • 2-Butenoic acid,4-(dimethylamino)-, hydrochloride (1:1), (2E)-
  • trans-4-Dimethylaminocrotonic acid hydrochloride(848133-35-7)
  • (E)-4-(DIMETHYLAMINO)BUT-2-ENOIC ACID HCL
  • (e)-4-(dimethylamino)-2-butenoic acid hydrochloride
  • 4-DiMethylaMino-But-2-Enoic Acid Hcl Salt
  • trans-4-Dimethylaminocrotonic acid hydrochloride
  • TRANS-4-DIMETHYLAMINOCROTONIC ACID HCL
  • 2-BUTENOIC ACID, 4-(DIMETHYLAMINO)-, HYDROCHLORIDE
  • (E)-4-(dimethylamino)but-2-enoic acid hydrochloride
  • Afatinib intermediate E
  • (2E)-4-(diMethylaMino)but-2-enoic acid hydrochloride
  • trans-4-(DiMethylaMino)-2-butenoic Acid Hydrochloride
  • trans-4-Dimethylaminocrotonic acid hydrochloride (E)-4-(Dimethylamino)-2-butenoic acid hydrochloride
  • (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride, trans
  • 2-Butenoic acid, 4-(dimethylamino)-, hydrochloride (1:1)
  • (2E)-4-(Dimethylamino)but-2-enoic acid?hydrochloride (1:1)
  • (E)-4-Dimethylaminocrotonic Acid Hydrochloride
  • trans-4-Dimethylaminocrotonic acid hydrochloride ISO 9001:2015 REACH
  • THRX-196194
  • (E)-4-(Dimethylamino)-2-buteno
  • (2E)-4-(dimethylamino)-2-Butenoic acid hydrochloride (1:1)
  • (2E)-4-(Dimethylamino)but-2-enoic acid HCl
  • trans-4-Dimethylaminocrotonic acid hydrochloride,(E)-4-(Dimethylamino)But-2-Enoic Acid Hydrochloride
  • 848133-35-7
  • Others chemical reagents
  • Amines
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • 848133-35-7