Trans-4-(Boc-amino)cyclohexanecarboxylic acid

Product Name: Trans-4-(Boc-amino)cyclohexanecarboxylic acid
CAS No.: 53292-89-0
Chemical Name: Trans-4-(Boc-amino)cyclohexanecarboxylic acid
Synonyms: TRANS-4-(BOC-AMINO)CYCLOHEXANECARBOXYLIC ACID;RARECHEM AR PA 0013;trans-4-(Boc-Amino);BOC-1,4-TRANS-ACHC-OH;Boc-Trans-1,4-ACHC-OH;BOC-1,4-TRANS-ACHC-OH USP/EP/BP;Trans-4-cyclohexanecarboxylic acid;Trans-4-Boc-cyclohexanecarboxylic acid;N-BOC-trans-4-cyclohexanecarboxylic Acid;trans-N-4-Aminocyclohexyl carboxylic acid
CBNumber: CB9170199
Molecular Formula: C12H21NO4
Formula Weight: 243.3
MOL File: 53292-89-0.mol

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Trans-4-(Boc-amino)cyclohexanecarboxylic acid Property

Melting point:: 181.0 to 185.0 °C
Boiling point:: 396.7±31.0 °C(Predicted)
Density: 1.12±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform, Methanol (Slightly)
pka: 4.76±0.10(Predicted)
form: Powder
color: White
BRN: 7641071
InChI: InChI=1S/C12H21NO4/c1-12(2,3)17-11(16)13-9-6-4-8(5-7-9)10(14)15/h8-9H,4-7H2,1-3H3,(H,13,16)(H,14,15)/t8-,9-
InChIKey: KXMRDHPZQHAXML-KYZUINATSA-N
SMILES: [C@@H]1(C(O)=O)CC[C@@H](NC(OC(C)(C)C)=O)CC1
CAS DataBase Reference: 53292-89-0(CAS DataBase Reference)

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Safety

WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B3250
Product name: trans-4-(tert-Butoxycarbonylamino)cyclohexanecarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $141
Updated: 2025/07/31

TCI Chemical

Product number: B3250
Product name: trans-4-(tert-Butoxycarbonylamino)cyclohexanecarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $564
Updated: 2025/07/31

TRC

Product number: B667860
Product name: Boc-trans-4-aminocyclohexanecarboxylicacid
Packaging: 1g
Price: $55
Updated: 2021/12/16

Usbiological

Product number: 262097
Product name: trans-Boc-4-aminocyclohexane carboxylic acid
Packaging: 10g
Price: $694
Updated: 2021/12/16

TRC

Product number: B667860
Product name: Boc-trans-4-aminocyclohexanecarboxylicacid
Packaging: 25g
Price: $350
Updated: 2021/12/16

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Trans-4-(Boc-amino)cyclohexanecarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

Trans-4-(Boc-amino)cyclohexanecarboxylic acid is a reagent to synthesize N-myristoyltransferase and CD38 inhibitors.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Chemical Reactivity

Trans-4-(Boc-amino)cyclohexanecarboxylic acid is stable under normal conditions, it reacts with strong oxidizing agents.

Synthesis

24424-99-5

1776-53-0

53292-90-3

1. To a stirred aqueous solution (10 mL) of trans-4-aminocyclohexanecarboxylic acid (1 g, 6.98 mmol) in tert-butanol (10 mL) and NaOH (0.307 g, 7.68 mmol) at 0 °C was slowly added di-tert-butyl dicarbonate (1.7 g, 7.68 mmol). 2. The reaction mixture was gradually warmed to room temperature with continuous stirring overnight. 3. Upon completion of the reaction, hexane (50 mL) was added to the mixture and the pH was adjusted to about 6 with 6N HCl. 4. 4. The reaction mixture was extracted with ethyl acetate (3 x 50 mL), the organic phases were combined and washed with brine solution (25 mL). 5. The organic phase was concentrated under pressure to give the white solid product cis-4-((tert-butoxycarbonyl)amino)cyclohexanecarboxylic acid (1.4 g, 82.8% yield). 6. The product was confirmed by mass spectrometry (ES-), m/z 242 [M-H]-.

References

[1] Patent: US2017/348315, 2017, A1. Location in patent: Paragraph 0400
[2] Patent: WO2010/45987, 2010, A1. Location in patent: Page/Page column 43-44
[3] European Journal of Medicinal Chemistry, 2001, vol. 36, # 3, p. 265 - 286
[4] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 2, p. 89 - 93

Trans-4-(Boc-amino)cyclohexanecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Trans-4-(Boc-amino)cyclohexanecarboxylic acid Suppliers

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View Lastest Price from Trans-4-(Boc-amino)cyclohexanecarboxylic acid manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: trans-4-(Boc-Amino)cyclohexanecarboxylic acid 53292-89-0
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-24

Shaanxi Dideu New Materials Co. Ltd

Product: Trans-4-(Boc-amino)cyclohexanecarboxylic acid 53292-89-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-08

Shanghai Yongzeng Technology Co.,Ltd

Product: Trans 4-Boc-amino cyclohexane carboxylia acid 53292-89-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kgs
Release date: 2024-09-03

53292-89-0, Trans-4-(Boc-amino)cyclohexanecarboxylic acidRelated Search:

trans-4-Dimethylaminocrotonic acid hydrochloride Trans-4-(Maleimidomethyl)cyclohexanecarboxylic Acid trans-4-Aminocyclohexanemethanol 1-Cyclohexene-1-carboxylicacid,4-(aminomethyl)-(9CI) TERT-BUTYL TRANS-4-AMINOCYCLOHEXYLMETHYLCARBAMATE 1-METHYL-PROP-2-YNYLAMINE HYDROCHLORIDE Methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate BOC-TRANS-4-AMINOCYCLOHEXANOL Cyclohexylamine 4-AMINOCYCLOHEXANECARBOXYLIC ACID BOC-1,4-TRANS-ACHC-OH BOC-1,2-TRANS-ACHC-OH 7-(tert-butoxycarbonyl)-7-azabicyclo[2.2.1]heptane-1-carboxylic acid 4-TERT-BUTOXYCARBONYLAMINO-CUBANE-1-CARBOXYLIC ACID 4-(TERT-BUTOXYCARBONYLAMINO)BICYCLO[2.2.2]OCTANE-1-CARBOXYLIC ACID 4-(BOC-AMINO)CYCLOHEXANECARBOXYLIC ACID METHYL 4-(TERT-BUTYLCARBONYLAMINO)CUBANECARBOXYLATE FMOC-1, 1-ACCH(4-AMINO-BOC)

RARECHEM AR PA 0013

TRANS-4-TERT-BUTOXYCARBONYLAMINOCYCLOHEXANECARBOXYLIC ACID

TRANS-4-(BOC-AMINO)CYCLOHEXANECARBOXYLIC ACID

TRANS-1-(T-BUTYLOXYCARBONYLAMINO)CYCLOHEXYL-4-CARBOXYLIC ACID

TRANS-1-(TERT-BUTYLOXYCARBONYL-AMINO)-CYCLOHEXYL-4-CARBOXYLIC ACID

BOC-1,4-TRANS-ACHC-OH

BOC-TRANS-1,4-AMINOCYCLOHEXANE CARBOXYLIC ACID

BOC-TRANS-4-AMINOCYCLOHEXANE-1-CARBOXYLIC ACID

BOC-TRANS-4-AMINOCYCLOHEXANE CARBOXYLIC ACID

N-BOC-TRAN(S)-4-AMINOCYCLOHEXANECARBOXYLIC ACID

Trans-4-Boc-cyclohexanecarboxylic acid

trans-4-[(N-tert-butoxycarbonyl)aMino]-1-cyclohexanecarboxylic acid

trans-Boc-4-aminocyclohexane carboxylic acid

rel-(1R,4R)-4-{[(tert-butoxy)carbonyl]aMino}cyclohexane-1-carboxylic acid

Cyclohexanecarboxylicacid, 4-[[(1,1-diMethylethoxy)carbonyl]aMino]-, trans-

(1r,4r)-4-((tert-butoxycarbonyl)aMino)cyclohexanecarboxylic acid

Boc-Trans-1,4-ACHC-OH

(1r,4r)-4-{[(tert-butoxy)carbonyl]amino}cyclohexane-1-carboxylic acid

Trans 4-Boc-aMino cyclohexane carboxylia acid

N-BOC-trans-4-Aminocyclohexane-1-carboxylic acid

trans-4-((tert-Butoxycarbonyl)amino)cyclohexane-1-carboxylic acid

trans-4-(Boc-Amino)

Boc-trans-4-aminocyclohexane carboxylic acid≥ 99% (GC)

trans-4-(tert-Butoxycarbonylamino)cyclohexanecarboxylic Acid &gt

N-BOC-trans-4-cyclohexanecarboxylic Acid

Boc-trans-4-aminocyclohexane-1-carboxylicaci

BOC-1,4-TRANS-ACHC-OH USP/EP/BP

trans-N-4-Aminocyclohexyl carboxylic acid

Trans-4-(tert-butoxycarbonylamino)cyclohexanoic acid

Trans-4-cyclohexanecarboxylic acid

<i>trans</i>-4-(Boc-amino)cyclohexanecarboxylic acid

trans-N-Boc-4-aminocyclohexanecarboxylic acid

53292-89-0

Unnatural Amino Acid Derivatives

Peptide Synthesis

Specialty Synthesis

Alicyclic Amino Acids

Peptide Synthesis

Unnatural Amino Acid Derivatives

53292-89-0