BOC-TRANS-4-AMINOCYCLOHEXANOL

Product Name: BOC-TRANS-4-AMINOCYCLOHEXANOL
CAS No.: 111300-06-2
Chemical Name: BOC-TRANS-4-AMINOCYCLOHEXANOL
Synonyms: 104582;tert-butyl (1r;BOC-TRANS-4-AMINOCYCLOHEXANOL;TRANS-4-BOC-AMINOCYCLOHEXANOL;Trans-4-n-boc-aminocylohexanol;TRANS-4-N-BOC-AMINOCYCLOHEXANOL;TRANS-N-4-BOC-AMINOCYCLOHEXANOL;TRANS-N-BOC-4-AMINO-CYCLOHEXANOL;TRANS-4-BOC-AMINO-1-CYCLOHEXANOL;4r)-4-hydroxycyclohexylcarbaMate
CBNumber: CB3708479
Molecular Formula: C11H21NO3
Formula Weight: 215.29
MOL File: 111300-06-2.mol

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BOC-TRANS-4-AMINOCYCLOHEXANOL Property

Melting point:: 172-173°C
Boiling point:: 337.7±31.0 °C(Predicted)
Density: 1.06±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform. Ethyl Acetate
form: powder to crystal
pka: 12.36±0.40(Predicted)
color: White to Almost white
InChIKey: DQARDWKWPIRJEH-KYZUINATSA-N
CAS DataBase Reference: 111300-06-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
Hazard Note: Irritant
HS Code: 2906190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B3564
Product name: trans-4-(tert-Butoxycarbonylamino)cyclohexanol
Purity: >98.0%(GC)(N)
Packaging: 1g
Price: $27
Updated: 2025/07/31

TCI Chemical

Product number: B3564
Product name: trans-4-(tert-Butoxycarbonylamino)cyclohexanol
Purity: >98.0%(GC)(N)
Packaging: 5g
Price: $84
Updated: 2025/07/31

TRC

Product number: B617685
Product name: trans-4-(Boc-amino)cyclohexanol
Packaging: 25g
Price: $240
Updated: 2021/12/16

TRC

Product number: B617685
Product name: trans-4-(Boc-amino)cyclohexanol
Packaging: 100g
Price: $725
Updated: 2021/12/16

Apolloscientific

Product number: OR3290
Product name: trans-4-Aminocyclohexan-1-ol,N-BOCprotected
Purity: 98%
Packaging: 1g
Price: $14
Updated: 2021/12/16

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BOC-TRANS-4-AMINOCYCLOHEXANOL Chemical Properties,Usage,Production

Uses

trans-4-(Boc-amino)cyclohexanol is an intermediate in the synthesis of potent activators of Heme-regulated inhibitor kinase.

Synthesis

24424-99-5

50910-54-8

111300-06-2

Step 1: trans-4-Aminocyclohexanol hydrochloride (5.0 g, 33 mmol) was dissolved in 1,4-dioxane (100 mL) and the resulting solution was cooled to 0 °C. Aqueous sodium hydroxide solution (40 mL, 1 N) was slowly added and the reaction mixture was stirred for 15 minutes. Subsequently, di-tert-butyl dicarbonate (7.9 g, 36 mmol) pre-dissolved in 1,4-dioxane (65 mL) was added. The reaction mixture was stirred at room temperature for 14 hours. Upon completion of the reaction, the reaction mixture was neutralized with 1 N hydrochloric acid and extracted with ethyl acetate. The organic phase was washed sequentially with 1 N hydrochloric acid, water and saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated in vacuum to give the white solid product trans-4-BOC-aminocyclohexanol (7.0 g, 100% yield). Mass spectrometry analysis showed (M + H)+ = 216.15.

References

[1] Patent: US2005/54626, 2005, A1. Location in patent: Page/Page column 47
[2] Heterocycles, 2002, vol. 58, p. 471 - 504
[3] Patent: WO2007/67629, 2007, A1. Location in patent: Page/Page column 63

BOC-TRANS-4-AMINOCYCLOHEXANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-TRANS-4-AMINOCYCLOHEXANOL Suppliers

Americas 1 Canada 1 China 152 Europe 1 Germany 2 India 7 Japan 1 United Kingdom 8 United States 30 Global 203

J & K SCIENTIFIC LTD.

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View Lastest Price from BOC-TRANS-4-AMINOCYCLOHEXANOL manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: BOC-TRANS-4-AMINOCYCLOHEXANOL 111300-06-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: BOC-TRANS-4-AMINOCYCLOHEXANOL 111300-06-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000kgs
Release date: 2020-01-02

111300-06-2, BOC-TRANS-4-AMINOCYCLOHEXANOLRelated Search:

Carbamic acid, 3-azabicyclo[3.1.0]hex-6-yl-, 1,1-dimethylethyl ester, tert-butyl 1H-pyrrol-2-ylcarbamate 2-(BOC-AMINO)-3-METHYLPYRIDINE tert-butyl (3-fluoropropyl)(2-hydroxyethyl)carbamate tert-butyl (3-formyl-4-hydroxyphenyl)carbamate TRANS-(4-HYDROXY-CYCLOHEXYLMETHYL)-CARBAMIC ACID TERT-BUTYL ESTER CarbaMic acid,[trans-4-[[[(1,1-diMethylethoxy)carbonyl]aMino]Methyl]cyclohexyl]-, phenylMethyl ester Cyclohexanol N-(3-AMino[1,1'-biphenyl]-4-yl)-carbaMic Acid tert-Butyl Ester tert-butyl (2-bromo-3-fluorophenyl)carbamate tert-Butyl(3-formylbicyclo[1.1.1]pentan-1-yl)carbamate tert-butyl (3-(hydroxymethyl)bicyclo[1.1.1]pentan-1-yl)carbamate tert-butyl (2,2,3,3-tetramethylcyclopropyl)carbamate tert-butyl (3,5-dibromopyrazin-2-yl)carbamate Methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate BOC-1,4-TRANS-ACHC-OH TERT-BUTYL TRANS-4-FORMYLCYCLOHEXYLCARBAMATE 4-Aminocyclohexanol

BOC-TRANS-4-AMINOCYCLOHEXANOL

TERT-BUTYL TRANS-4-HYDROXYCYCLOHEXYLCARBAMATE

N-T-BOC-TRANS-4-AMINO CYCLOHEXANOL

TRANS-4-N-BOC-AMINOCYCLOHEXANOL

TRANS-(4-HYDROXY-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER

TRANS-4-BOC-AMINO-1-CYCLOHEXANOL

TRANS-4-BOC-AMINOCYCLOHEXANOL

TRANS-T-BUTYL-4-HYDROXYCYCLOHEXYLCARBAMATE

TRANS-N-BOC-4-AMINO-CYCLOHEXANOL

TRANS-N-4-BOC-AMINOCYCLOHEXANOL

trans-4-Aminocyclohexanol, N-BOC protected

trans-tert-Butyl-4-hydroxycyclohexylcarbamate

Boc-trans-4-aminocyclohexanol/CH63857

Boc-trans-4-aminocyclohexanol/CH85402

trans-4-Aminocyclohexanol, N-BOC protected 98%

trans-4-(tert-Butoxycarbonylamino)cyclohexanol

tert-butyl ((1r,4r)-4-hydroxycyclohexyl)carbaMate

104582

tert-Butyl (trans-4-hydroxycyclohex-1-yl)carbamate, trans-4-[(tert-Butoxycarbonyl)amino]cyclohexan-1-ol

trans-4-Aminocyclohexan-1-ol, N-BOC protected 98%

CarbaMic acid, N-(trans-4-hydroxycyclohexyl)-, 1,1-diMethylethyl ester

N-(trans-4-Hydroxy-cyclohexyl)-carbamic acid tert-butyl ester

trans-4-Aminocyclohexan-1-ol,N-BOCprotected98%

<i>trans</i>-4-(<i>tert</i>-Butoxycarbonylamino)cyclohexanol

4r)-4-hydroxycyclohexylcarbaMate

tert-butyl (1r

trans-4-(tert-Butoxycarbonylamino)cyclohexanol &gt

tert-butyl(trans-4-hydroxcyclohexyl)carbamate

trans-N-4-Boc-aminocyclohexanol, 98%

trans-4-Aminocyclohexan-1-ol, N-BOC protected

Trans-4-n-boc-aminocylohexanol

111300-06-2

11300-06-2

pharmacetical

API intermediates

pharmaceutical