Methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate

Product Name: Methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate
CAS No.: 146307-51-9
Chemical Name: Methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate
Synonyms: RMA-411;trans-Methyl 4-((tert-butoxycarbonyl);Methyl trans-4-N-BOC-cyclohexanecarboxylate;Methyl trans-4-(Boc-aMino)cyclohexanecarboxylate;TRANS-METHYL 4-(BOC-AMINO)CYCLOHEXANECARBOXYLATE;4-tert-butocycarbonylaMinocyclohexanecarboxylicacidMethylester;Methyl trans-4-(tert-Butylcarbonylamino)cyclohexanecarboxylate;Methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate;4-tert-Butoxycarbonylamino-cyclohexanecarboxylic acid methyl...;trans-Methyl 4-((tert-butoxycarbonyl)aMino)cyclohexanecarboxylate
CBNumber: CB02490139
Molecular Formula: C13H23NO4
Formula Weight: 257.33
MOL File: 146307-51-9.mol

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Methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate Property

Boiling point:: 349.0±31.0 °C(Predicted)
Density: 1.07
storage temp.: 2-8°C
pka: 12.28±0.40(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C13H23NO4/c1-13(2,3)18-12(16)14-10-7-5-9(6-8-10)11(15)17-4/h9-10H,5-8H2,1-4H3,(H,14,16)/t9-,10-
InChIKey: RKOQMDUDKCMVFW-MGCOHNPYSA-N
SMILES: [C@@H]1(C(OC)=O)CC[C@@H](NC(OC(C)(C)C)=O)CC1
CAS DataBase Reference: 146307-51-9

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M296523
Product name: Methyltrans-4-(tert-Butylcarbonylamino)cyclohexanecarboxylate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 075547
Product name: Methyl trans-4-(tert-butoxycarbonylamino)-cyclohexanecarboxylate
Purity: 95+%
Packaging: 1g
Price: $59
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4258-1-16
Product name: Methyl trans-4-(Boc-amino)cyclohexanecarboxylate
Packaging: 250mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-W023036
Product name: trans-Methyl4-((tert-butoxycarbonyl)amino)cyclohexanecarboxylate
Purity: ≥97.0%
Packaging: 10g
Price: $73
Updated: 2021/12/16

ChemScene

Product number: CS-W023036
Product name: trans-Methyl4-((tert-butoxycarbonyl)amino)cyclohexanecarboxylate
Purity: ≥97.0%
Packaging: 1g
Price: $14
Updated: 2021/12/16

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Methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate Chemical Properties,Usage,Production

Synthesis

24424-99-5

62456-15-9

146307-51-9

Methyl trans-4-aminocyclohexanecarboxylate (132 g, 401 mmol) was suspended in dichloromethane (1000 ml) under cooling conditions in an ice bath. Triethylamine (123 ml, 882 mmol) and di-tert-butyl dicarbonate (Boc2O, 101 ml, 440 mmol) were sequentially added to the suspension and the reaction was stirred for 10 minutes. Subsequently, the reaction mixture was transferred to room temperature and continued stirring for 2 hours. After completion of the reaction, the solvent was removed by rotary evaporator under reduced pressure. The residue was dissolved in aqueous citric acid solution (prepared by dissolving 50 g of citric acid monohydrate in 400 ml of water, pH adjusted to 4) and extracted with ethyl acetate. The organic phase was sequentially washed with water and dried with anhydrous magnesium sulfate. Finally, the organic phase was concentrated under reduced pressure to quantitatively obtain the target product methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate. The product was characterized by 1H-NMR (DMSO-d6) with the following chemical shift δ (ppm): 1.06-1.25 (m, 2H), 1.25-1.43 (m, 2H), 1.37 (s, 9H), 1.75-1.94 (m, 4H), 2.19 (tt, 1H, J = 11.7,3.9 Hz), 3.07-3.24 (m. 1H), 3.58 (s, 3H), 6.74 (d, 1H, J = 6.6 Hz).

References

[1] Patent: US2010/273841, 2010, A1. Location in patent: Page/Page column 21
[2] Patent: WO2011/92293, 2011, A2. Location in patent: Page/Page column 99

Methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate Suppliers

China 98 India 1 United Kingdom 1 United States 5 Global 105

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View Lastest Price from Methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate 146307-51-9
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-24

Pharmahands (Taizhou) Co., Ltd.

Product: Methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate 146307-51-9
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1g
Purity: 98%
Supply Ability: 200KG/MONTH
Release date: 2020-11-23

146307-51-9, Methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylateRelated Search:

BOC-TRANS-4-AMINOCYCLOHEXANOL BOC-1,4-TRANS-ACHC-OH TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID tert-butyl (1r,4r)-4-aminocyclohexane-1-carboxylate hydrochloride TERT-BUTYL TRANS-4-FORMYLCYCLOHEXYLCARBAMATE Methyl trans-4-AMinocyclohexanecarboxylate Hydrochloride TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE tert-butyl (1r,4r)-4-aminocyclohexane-1-carboxylate trans-Methyl-4-aMinocyclohexanecarboxylate TRANS-4-AMINO-CYCLOHEXANE CARBOXYLIC ACID HYDROCHLORIDE (1r,4r)-methyl 4-(hydroxymethyl)cyclohexanecarboxylate trans-4-Aminocyclohexanemethanol

4-tert-butocycarbonylaMinocyclohexanecarboxylicacidMethylester

4-tert-ButoxycarbonylaMino-cyclohexanecarboxylic acid Methyl ester

(1r,4r)-Methyl4-((tert-butoxycarbonyl)aMino)cyclohexanecarboxylate

trans-Methyl 4-((tert-butoxycarbonyl)aMino)cyclohexanecarboxylate

Methyl trans-4-(Boc-aMino)cyclohexanecarboxylate

trans-methyl-4-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate)

trans-Methyl 4-((tert-butoxycarbonyl)

TRANS-METHYL 4-(BOC-AMINO)CYCLOHEXANECARBOXYLATE

trans-4-(tert-Butoxycarbonylamino)cyclohexane-1-carboxylic acid methyl ester

trans-4-(tert-Butoxycarbonylamino)cyclohexanecarboxylic acid methyl ester

Methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate

Methyl trans-4-N-BOC-cyclohexanecarboxylate

Cyclohexanecarboxylic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester, trans-

Methyl trans-4-(tert-Butylcarbonylamino)cyclohexanecarboxylate

4-tert-Butoxycarbonylamino-cyclohexanecarboxylic acid methyl...

methyl 4-[(2-methylpropan-2-yl)oxycarbonylamino]cyclohexane-1-carboxylate

RMA-411

Methyl trans-4-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexanecarboxylate

methyl Rel-(1r,4r)-4-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate

146307-51-9

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