TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE

Product Name: TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE
CAS No.: 239074-29-4
Chemical Name: TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE
Synonyms: tert-butyl ((1r,4r)-4-(hydroxymethyl)cyclohexyl)carbamate;tert-Butyl (trans-4-(hydroxymethyl);trans-4-(Boc-amino)cyclohexanemethanol;trans-1-(Boc-amino)-4-(hydroxymethyl)cyclohexane;trans-1-(Boc-amino)-4-(hydroxymethyl)cyclohexane,97%;trans-1-(Boc-aMino)-4-(hydroxyMethyl)cyclohexane, 97%;TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE;Trans tert-butyl 4-(hydroxyMethyl)cyclohexyl)carbaMate;trans-4-(tert-Butoxycarbonylamino)cyclohexane-1-methanol;tert-butyl N-[trans-4-(hydroxymethyl)cyclohexyl]carbamate
CBNumber: CB5301665
Molecular Formula: C12H23NO3
Formula Weight: 229.32
MOL File: 239074-29-4.mol

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TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE Property

Boiling point:: 351.6±11.0 °C(Predicted)
Density: 1.05±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Slightly Soluble (4.4 g/L) (25°C).
form: Solid
pka: 12.50±0.40(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C12H23NO3/c1-12(2,3)16-11(15)13-10-6-4-9(8-14)5-7-10/h9-10,14H,4-8H2,1-3H3,(H,13,15)/t9-,10-
InChIKey: SGNKPJPMWHKOJO-MGCOHNPYSA-N
SMILES: C(OC(C)(C)C)(=O)N[C@@H]1CC[C@@H](CO)CC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: H950080
Product name: (trans-4-Hydroxymethylcyclohexyl)carbamicAcidtert-ButylEster
Packaging: 250mg
Price: $205
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB46677
Product name: tert-Butyl trans-4-(hydroxymethyl)cyclohexylcarbamate
Packaging: 1g
Price: $120
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB46677
Product name: tert-Butyl trans-4-(hydroxymethyl)cyclohexylcarbamate
Packaging: 500mg
Price: $80
Updated: 2021/12/16

Matrix Scientific

Product number: 089350
Product name: tert-Butyl trans-(4-hydroxymethyl)-cyclohexylcarbamate
Packaging: 500mg
Price: $29
Updated: 2021/12/16

Matrix Scientific

Product number: 089350
Product name: tert-Butyl trans-(4-hydroxymethyl)-cyclohexylcarbamate
Packaging: 1g
Price: $44
Updated: 2021/12/16

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TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE Chemical Properties,Usage,Production

Uses

trans-1-(Boc-amino)-4-(hydroxymethyl)cyclohexane is used to prepare C-2 hydroxyethyl imidazopyrrolo pyridines as JAK1 inhibitors. It is also used to prepare Mer kinase inhibitors for treatment of pediatric acute lymphoblastic leukemia.

Synthesis

146307-51-9

239074-29-4

General procedure for the synthesis of tert-butyl trans-(4-hydroxymethyl)cyclohexylcarbamate from methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate: a suspension of LiAlH4 (9.0 g, 0.236 mol, 1.12 eq.) in THF (500 mL) was cooled to 0 °C under ice bath conditions. Subsequently, a solution of methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate (54.3 g, 0.21 mol, 1.0 eq.) in THF (200 mL) was slowly added to ensure that the reaction temperature was maintained below 10 °C. After the addition was completed, the reaction mixture was transferred to room temperature and stirred overnight. Upon completion of the reaction, the reaction was carefully quenched with sodium sulfate decahydrate (27 g) at 15 °C to 25 °C. The insoluble material was removed by filtration and the filtrate was concentrated to give tert-butyl trans-(4-hydroxymethyl)cyclohexylcarbamate (43 g, 89% yield) as a white powder.MS-ESI: [M + 1]+: 229.1.

References

[1] Patent: WO2018/67422, 2018, A1. Location in patent: Page/Page column 44; 45
[2] Patent: WO2018/69863, 2018, A1. Location in patent: Page/Page column 121-122
[3] Patent: EP2017261, 2009, A1. Location in patent: Page/Page column 30-31
[4] Patent: US2010/273841, 2010, A1. Location in patent: Page/Page column 22
[5] Patent: WO2011/92293, 2011, A2. Location in patent: Page/Page column 99-100

TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE Suppliers

China 92 Hungary 1 India 4 United Kingdom 1 United States 12 Global 110

Shanghai Mayzem Pharmtech Co., Ltd.

Tel: 18501708306; 18501708306
Fax: 021-68362870
Email: sales@mayzem.com
Country: China
ProdList: 518
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Taizhou Elitechemie MediPharma Technology Co., Ltd.

Tel: 523-86810021 18921709486
Fax: gwli@elitechemie.com
Email: gwli@elitechemie.com
Country: China
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TaiChem Taizhou Limited

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Alfa Aesar

Tel: 400-6106006
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Beijing HwrkChemical Technology Co., Ltd

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Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
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Energy Chemical

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Accela ChemBio Co.,Ltd.

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Email: sales@accelachem.com
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Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
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shanghai Rainbow MediTech.Co.Ltd.

Tel: 021-64968085,64968086-5815,5812; 13472757003
Fax: +86 21 64968087
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Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
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View Lastest Price from TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: (trans-4-Hydroxymethylcyclohexyl)carbamic acid tert-butyl ester 239074-29-4
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-24

Pharmahands (Taizhou) Co., Ltd.

Product: TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE 239074-29-4
Price: US $0.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg/month
Release date: 2020-11-05

Career Henan Chemical Co

Product: TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE 239074-29-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-07

239074-29-4, TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATERelated Search:

tert-butyl (1r,4r)-4-aminocyclohexane-1-carboxylate trans-Methyl-4-aMinocyclohexanecarboxylate TRANS-4-AMINO-CYCLOHEXANE CARBOXYLIC ACID HYDROCHLORIDE (1r,4r)-methyl 4-(hydroxymethyl)cyclohexanecarboxylate Methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate trans-4-Aminocyclohexanemethanol BOC-1,4-TRANS-ACHC-OH TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE 4-(TERT-BUTOXYCARBONYLAMINO)BICYCLO[2.2.2]OCTANE-1-CARBOXYLIC ACID 4-(BOC-AMINO)CYCLOHEXANECARBOXYLIC ACID METHYL 4-(TERT-BUTYLCARBONYLAMINO)CUBANECARBOXYLATE 4-TERT-BUTOXYCARBONYLAMINO-CUBANE-1-CARBOXYLIC ACID 7-(tert-butoxycarbonyl)-7-azabicyclo[2.2.1]heptane-1-carboxylic acid BOC-(4-CIS/TRANS)-1, 1-ACCH(4-CH2OH) 1, 1-ACCH(4-AMINO-BOC)-OME FMOC-1, 1-ACCH(4-AMINO-BOC) BOC-CIS-1,4-AMINO-1-CYCLOHEXANE CARBOXYLIC ACID 1-BOC-AMINOCYCLOHEXANE-1,4-DICARBOXYLIC ACID

TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE

Trans tert-butyl 4-(hydroxyMethyl)cyclohexyl)carbaMate

carbamic acid, n-[trans-4-(hydroxymethyl)cyclohexyl]-, 1,1-dimethylethyl ester

tert-butyl ((1r,4r)-4-(hydroxymethyl)cyclohexyl)carbamate

tert-butyl N-[trans-4-(hydroxymethyl)cyclohexyl]carbamate

trans-4-(Boc-amino)cyclohexanemethanol

tert-Butyl trans-4-(hydroxymethyl)cyclohexylcarbamate FP160825

tert-Butyl (trans-4-(hydroxymethyl)

trans-1-(Boc-aMino)-4-(hydroxyMethyl)cyclohexane, 97%

(trans-4-Hydroxymethylcyclohexyl)carbamic acid tert-butyl ester

trans-4-(tert-Butoxycarbonylamino)cyclohexane-1-methanol

trans-N-[4-(Hydroxymethyl)cyclohexyl]carbamic acid tert-butyl ester

trans-1-(Boc-amino)-4-(hydroxymethyl)cyclohexane,97%

N-[trans-4-(Hydroxymethyl)cyclohexyl]carbamic acid tert-butyl ester

N - [trans-4- (hydroxymethyl) cyclohexyl] aminomethyl tert butyl ester

trans-1-(Boc-amino)-4-(hydroxymethyl)cyclohexane

239074-29-4