4-(BOC-AMINO)CYCLOHEXANECARBOXYLIC ACID
- Product Name
- 4-(BOC-AMINO)CYCLOHEXANECARBOXYLIC ACID
- CAS No.
- 130309-46-5
- Chemical Name
- 4-(BOC-AMINO)CYCLOHEXANECARBOXYLIC ACID
- Synonyms
- 4-(BOC-AMINO)CYCLOHEXANECARBOXYLIC ACID;4-N-BOC-AMINOCYCLOHEXANE CARBOXYLIC ACID;4-TERT-BUTOXYCARBONYLAMINO-CYCLOHEXANECARBOXYLIC ACID;4-Aminocyclohexane-1-carboxylic acid, N-BOC protected;1-(t-Butyloxycarbonylamino)cyclohexyl-4-carboxylic acid;4-Aminocyclohexane-1-carboxylic acid, N-BOC protected 98%;4-[(tert-Butoxycarbonyl)amino]cyclohexane-1-carboxylic acid;4-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclohexanecarboxylic acid;Cyclohexanecarboxylicacid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-;4-[(2-methylpropan-2-yl)oxycarbonylamino]cyclohexane-1-carboxylic acid
- CBNumber
- CB4369026
- Molecular Formula
- C12H21NO4
- Formula Weight
- 243.3
- MOL File
- 130309-46-5.mol
4-(BOC-AMINO)CYCLOHEXANECARBOXYLIC ACID Property
- Boiling point:
- 396.7±31.0 °C(Predicted)
- Density
- 1.12
- storage temp.
- 2-8°C
- solubility
- Soluble in methanol and tetrahydrofuran(THF).
- pka
- 4.76±0.10(Predicted)
- form
- powder to crystal
- color
- White to Almost white
Safety
- WGK Germany
- 3
- HS Code
- 2922498590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B3248
- Product name
- 4-(tert-Butoxycarbonylamino)cyclohexanecarboxylic Acid (cis- and trans- mixture)
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $128
- Updated
- 2025/07/31
- Product number
- B3248
- Product name
- 4-(tert-Butoxycarbonylamino)cyclohexanecarboxylic Acid (cis- and trans- mixture)
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $418
- Updated
- 2025/07/31
- Product number
- Z6347
- Product name
- 4-(Boc-amino)cyclohexanecarboxylicacid
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- AK-25352
- Product name
- 4-((tert-Butoxycarbonyl)amino)cyclohexanecarboxylicacid
- Purity
- 97%
- Packaging
- 10g
- Price
- $89
- Updated
- 2021/12/16
- Product number
- 4258-1-09
- Product name
- 4-Aminocyclohexane-1-carboxylic acid, N-Boc protected
- Packaging
- 25g
- Price
- $480
- Updated
- 2021/12/16
4-(BOC-AMINO)CYCLOHEXANECARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
4-(Boc-amino)cyclohexanecarboxylic acid is used as pharmaceutical intermediate.
Synthesis
24424-99-5
1776-53-0
53292-90-3
To a stirred solution of trans-4-aminocyclohexanecarboxylic acid (1 g, 6.98 mmol) in tert-butanol (10 mL) and NaOH (0.307 g, 7.68 mmol) in water (10 mL) was slowly added di-tert-butyl dicarbonate (1.7 g, 7.68 mmol) at 0 °C. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, hexane (50 mL) was added to the mixture and the pH was adjusted to about 6 with 6 N HCl. Subsequently, the mixture was extracted with ethyl acetate (3 x 50 mL) and the organic phases were combined and washed with saturated brine solution (25 mL). The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the white powdery product cis-4-((tert-butoxycarbonyl)amino)cyclohexanecarboxylic acid (1.4 g, 82.8% yield). Mass spectrum (ES-) m/z 242 [M-H]-.
References
[1] Patent: US2017/348315, 2017, A1. Location in patent: Paragraph 0400
[2] Patent: WO2010/45987, 2010, A1. Location in patent: Page/Page column 43-44
[3] European Journal of Medicinal Chemistry, 2001, vol. 36, # 3, p. 265 - 286
[4] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 2, p. 89 - 93
4-(BOC-AMINO)CYCLOHEXANECARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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