ChemicalBook > CAS DataBase List > 2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE

2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE

Product Name
2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE
CAS No.
111686-79-4
Chemical Name
2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE
Synonyms
pr934-423a;fpl12924aa;RemacemideHCl;REMACEMIDE HYDROCHLORIDE;2-AMino-N-(1,2-diphenylpropan-2-yl)acetaMide hydrochloride;2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE;2-diphenylethyl)acetamidemonohydrochloride(+-)-2-amino-n-(1-methyl-;2-amino-n-(1-methyl-1,2-diphenylethyl)-,monohydrochloride,(+-)-acetamid
CBNumber
CB2360100
Molecular Formula
C17H21ClN2O
Formula Weight
304.82
MOL File
111686-79-4.mol
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2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE Property

Melting point:
253-254°
storage temp. 
room temp
solubility 
H2O: >10mg/mL
form 
powder
color 
white to beige
Water Solubility 
Soluble to 100 mM in water
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-41-50/53
Safety Statements 
26-39-45-60-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
RTECS 
AB4349500
Toxicity
LD50 (calculated as base) in rats (mg/kg): ~50 i.v., ~900 orally (Muir, Palmer)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0335
Product name
Remacemide hydrochloride
Purity
≥98% (HPLC)
Packaging
10mg
Price
$148
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0335
Product name
Remacemide hydrochloride
Purity
≥98% (HPLC)
Packaging
50mg
Price
$540
Updated
2023/01/07
Tocris
Product number
1622
Product name
Remacemide hydrochloride
Purity
≥99%(HPLC)
Packaging
10
Price
$140
Updated
2021/12/16
Tocris
Product number
1622
Product name
Remacemide hydrochloride
Purity
≥99%(HPLC)
Packaging
50
Price
$592
Updated
2021/12/16
TRC
Product number
R143450
Product name
Remacemide hydrochloride
Packaging
2.5mg
Price
$140
Updated
2021/12/16
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2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Anticonvulsant (neuroprotective).

Biological Activity

Non-competitive NMDA receptor antagonist; blocks ion channel and allosteric modulatory site (IC 50 = 8-68 mM). Anticonvulsant in vivo and metabolizes to a more potent desglycine analog. Weakly blocks voltage-dependent Na + channels (IC 50 = 161 mM).

Biochem/physiol Actions

Remacemide HCl is a low affinity NMDA antagonist with anticonvulsant properties. Remacemide also been shown to block voltage-dependent sodium channels.

in vivo

Treatment with low- and high-dose Remacemide (100 mg/kg and 150 mg/kg) delays the acquisition of audio/visual discrimination (AVD) task performance in female Sprague-Dawley rats[3].

Animal Model:Female Sprague–Dawley rats ( 190-210 g )[3]
Dosage:100 mg/kg and 150 mg/kg
Administration:Orogastric gavage; once a day; 7 days
Result:Increased the number of sessions required to complete audio/visual discrimination (AVD) training.

2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE Suppliers

China 16 Germany 1 India 2 South Korea 1 United Kingdom 2 United States 9 Global 31
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111686-79-4, 2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDERelated Search:

2-AMINO-N-(TERT-BUTYL)ACETAMIDE HYDROCHLORIDE 2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE Ramacemide

  • REMACEMIDE HYDROCHLORIDE
  • 2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE
  • RemacemideHCl
  • 2-AMino-N-(1,2-diphenylpropan-2-yl)acetaMide hydrochloride
  • 2-amino-n-(1-methyl-1,2-diphenylethyl)-,monohydrochloride,(+-)-acetamid
  • 2-diphenylethyl)acetamidemonohydrochloride(+-)-2-amino-n-(1-methyl-
  • fpl12924aa
  • pr934-423a
  • 111686-79-4