10,12-TRICOSADIYNOIC ACID
- Product Name
- 10,12-TRICOSADIYNOIC ACID
- CAS No.
- 66990-30-5
- Chemical Name
- 10,12-TRICOSADIYNOIC ACID
- Synonyms
- TIMTEC-BB SBB009036;10,12-Tricosadiynoicaci;10,12-TRICOSADIYNOIC ACID;tricosa-10,12-diynoic acid;10,12-Tricosadiynoic acid - [T94776];10,12-Tricosadiynoic acid >=98.0% (GC);10,12-TRICOSADIYNOIC ACID, 97%10,12-TRICOSADIYNOIC ACID, 97%10,12-TRICOSADIYNOIC ACID, 97%10,12-TRICOSADIYNOIC ACID, 97%;10,12-Tricosadiynoic acid,ROS,mono- acylglycerol acyltransferase,10,12Tricosadiynoic acid,fatty,Diacylglycerol acyltransferase,SIRT1-AMPK,Diglyceride acyltransferase,metabolic,mitochondrial,oxidation,insulin,10,12 Tricosadiynoic acid,inhibit,triglyceride,Inhibitor,Acyltransferase,acyl-CoA:cholesterol acyltransferase,acid
- CBNumber
- CB2360625
- Molecular Formula
- C23H38O2
- Formula Weight
- 346.55
- MOL File
- 66990-30-5.mol
10,12-TRICOSADIYNOIC ACID Property
- Melting point:
- 56-60 °C
- storage temp.
- Refrigerator
- solubility
- DMSO : 100 mg/mL (288.56 mM）
- form
- Solid
- color
- White to off-white
- Water Solubility
- Insoluble in water.
- Sensitive
- Light Sensitive
- BRN
- 1880414
- CAS DataBase Reference
- 66990-30-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 91445
- Product name
- 10,12-Tricosadiynoic acid
- Purity
- ≥98.0% (GC)
- Packaging
- 5g
- Price
- $251.75
- Updated
- 2025/07/31
- Product number
- T1200
- Product name
- 10,12-Tricosadiynoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 100mg
- Price
- $14
- Updated
- 2021/12/16
- Product number
- T896460
- Product name
- 10,12-Tricosadiynoic acid
- Packaging
- 1mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 83105
- Product name
- 10,12-Tricosadiynoic acid
- Packaging
- 1g
- Price
- $50.73
- Updated
- 2021/12/16
- Product number
- 83102
- Product name
- 10,12-Tricosadiynoic acid
- Packaging
- 25g
- Price
- $496.57
- Updated
- 2021/12/16
10,12-TRICOSADIYNOIC ACID Chemical Properties,Usage,Production
Uses
It is an active pharmaceutical intermediate.
Definition
ChEBI: 10,12-tricosadiynoic acid is a very long-chain fatty acid.
in vivo
10,12-Tricosadiynoic acid (100 μg/kg; oral gavage; daily; for 8 weeks; male Wistar rats) treatment increases hepatic mitochondrial fatty acid oxidation (FAO) via activation of the SIRT1-AMPK (adenosine 5′-monophosphate-activated protein kinase) pathway and proliferator activator receptor α and reduces hydrogen peroxide accumulation in high fat diet-fed rats, which significantly decreases hepatic lipid and ROS contents, reduces body weight gain, and decreases serum triglyceride and insulin levels[1].
10,12-Tricosadiynoic acid (0 mg/kg, 37.5 mg/kg, 75 mg/kg, and 150 mg/kg diet) treatment does not affect weight gain, but significantly decreases peroxisomal β-oxidation in the liver, and increased body fat accumulation in Nile tilapia. The fish with impaired peroxisomal β-oxidation exhibited higher contents of serum lipid and peroxidation products, and alanine aminotransferase activity, and significantly lowered hepatic activities of superoxide dismutase and catalase[3].
| Animal Model: | Male Wistar rats (210-230 g) fed with high fat diet[1] |
| Dosage: | 100 μg/kg |
| Administration: | Oral gavage; daily; for 8 weeks |
| Result: | Reduced hydrogen peroxide accumulation in high fat diet-fed rats, which significantly decreased hepatic lipid and ROS contents, reduced body weight gain, and decreased serum triglyceride and insulin levels. |
10,12-TRICOSADIYNOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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