3-(2-PYRIDYL)-3-OXOPROPANENITRILE
Application- Product Name
- 3-(2-PYRIDYL)-3-OXOPROPANENITRILE
- CAS No.
- 54123-21-6
- Chemical Name
- 3-(2-PYRIDYL)-3-OXOPROPANENITRILE
- Synonyms
- Oxopyridinylpropanenitrile;b-oxo-2-Pyridinepropanenitrile;2-Pyridinepropanenitrile, β-oxo-;3-(2-PYRIDYL)-3-OXOPROPANENITRILE;3-OXO-3-(2-PYRIDYL)PROPANENITRILE;Beta-oxo-2-pyridinepropanenitrile;3-OXO-3-PYRIDIN-2-YL-PROPIONITRILE;3-oxo-3-pyridin-2-yl-propionatrile;3-OXO-2-PYRIDIN-3-YL-PROPIONITRILE;3-Oxo-3-pyridin-2-ylpropanenitrile
- CBNumber
- CB2362700
- Molecular Formula
- C8H6N2O
- Formula Weight
- 146.15
- MOL File
- 54123-21-6.mol
3-(2-PYRIDYL)-3-OXOPROPANENITRILE Property
- Melting point:
- 97-99°C
- Boiling point:
- 312.7±22.0 °C(Predicted)
- Density
- 1.177±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 6.05±0.10(Predicted)
- Appearance
- Brown to black Solid
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- O859213
- Product name
- 3-Oxo-3-(pyridin-2-yl)propanenitrile
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 4H37-1-P9
- Product name
- 3-Oxo-3-(pyridin-2-yl)propanenitrile
- Packaging
- 1g
- Price
- $199
- Updated
- 2021/12/16
- Product number
- 4H37-1-P9
- Product name
- 3-Oxo-3-(pyridin-2-yl)propanenitrile
- Packaging
- 100mg
- Price
- $52
- Updated
- 2021/12/16
- Product number
- 046716
- Product name
- 3-Oxo-3-(2-pyridinyl)propanenitrile
- Purity
- 98%
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- V6511
- Product name
- 3-Oxo-3-(2-pyridinyl)propanenitrile
- Packaging
- 1g
- Price
- $158
- Updated
- 2021/12/16
3-(2-PYRIDYL)-3-OXOPROPANENITRILE Chemical Properties,Usage,Production
Application
3-(2-PYRIDYL)-3-OXOPROPANENITRILE can be used as an organic synthesis intermediate and a pharmaceutical intermediate in laboratory research and development processes and in the synthesis of pharmaceutical chemicals.
Synthesis
2524-52-9
75-05-8
54123-21-6
Preparation of Intermediate 35 [General Procedure 14]: Intermediate 34 (3 g, 19.6 mmol) and acetonitrile (0.8 mL, 19.6 mmol, 1 equiv) were dissolved in toluene (10 mL) under dry conditions. This solution was slowly added to a mixture of sodium hydride (784 mg, 19.6 mmol, 1 equiv, 60% mineral oil dispersion) pre-suspended in toluene (50 mL) and the reaction temperature was maintained at 65 °C. The reaction mixture was stirred continuously at 65°C for 16 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched with ice-cold water (20 mL). The resulting solid was collected by filtration to afford Intermediate 35 (1.5 g, 53% yield) as a brown solid. The product was characterized by 1H NMR (CDCl3): δ 8.70 (d, J = 4.8Hz, 1H), 8.12 (d, J = 7.5Hz, 1H), 7.90-7.94 (m, 1H), 7.56-7.60 (m, 1H), 4.41 (s, 2H). Mass spectrometry analysis showed a molecular ion peak [M + H]+ of 147. Thin layer chromatography (TLC) analysis was performed with ethyl acetate as the unfolding agent and an Rf value of 0.40.
References
[1] Tetrahedron Letters, 2006, vol. 47, # 15, p. 2531 - 2534
[2] Patent: WO2011/126903, 2011, A2. Location in patent: Page/Page column 100
[3] Patent: WO2014/145986, 2014, A1. Location in patent: Paragraph 0267; 0268
[4] Patent: US2017/326125, 2017, A1. Location in patent: Paragraph 0406-0408
[5] Patent: US2014/179676, 2014, A1. Location in patent: Paragraph 0898; 0908
3-(2-PYRIDYL)-3-OXOPROPANENITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-(2-PYRIDYL)-3-OXOPROPANENITRILE manufacturers
- Product
- 3-(2-PYRIDYL)-3-OXOPROPANENITRILE 54123-21-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-14