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BUDIPINE

Product Name
BUDIPINE
CAS No.
57982-78-2
Chemical Name
BUDIPINE
Synonyms
budipin;BUDIPINE;BUDIPINE USP/EP/BP;BUDIPINE(FORR&DONLY);4,4-diphenyl-1-tert-butyl-piperidine;1-TERT-BUTYL-4,4-DIPHENYL-PIPERIDINE;1-(1,1-dimethylethyl)-4,4-diphenylpiperidine;1-(1,1-dimethylethyl)-4,4-diphenyl-piperidin;Piperidine,1-(1,1-dimethylethyl)-4,4-diphenyl-;monoamine oxidase type B (MAO-B),inhibit,CNS disorders,Parkinson disease,Budipine,Inhibitor,dopaminergic
CBNumber
CB2369325
Molecular Formula
C21H27N
Formula Weight
293.45
MOL File
57982-78-2.mol
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BUDIPINE Property

Melting point:
108.5°C
Boiling point:
425.29°C (rough estimate)
Density 
0.9665 (rough estimate)
refractive index 
1.4900 (estimate)
storage temp. 
2-8°C
solubility 
DMSO : 25 mg/mL (85.19 mM; Need ultrasonic)
form 
Solid
pka
10.36±0.10(Predicted)
color 
Light yellow to khaki
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
B820055
Product name
1-(tert-Butyl)-4,4-diphenylpiperidine
Packaging
1mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB156517
Product name
1-tert-butyl-4,4-Diphenyl-piperidine
Packaging
5mg
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB156517
Product name
1-tert-butyl-4,4-Diphenyl-piperidine
Packaging
10mg
Price
$80
Updated
2021/12/16
AK Scientific
Product number
M128
Product name
Budipine
Packaging
5mg
Price
$108
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB156517
Product name
1-tert-butyl-4,4-Diphenyl-piperidine
Packaging
25mg
Price
$150
Updated
2021/12/16
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BUDIPINE Chemical Properties,Usage,Production

Description

Parkinsan was launched in Germany as a centrally-active anti-Parkinsonian agent. It can be prepared in three steps: a Mannich-aldol sequence to assemble the 4-phenylpiperidine scaffold followed by a Friedel-Crafts reaction to introduce the second phenyl ring. Parkinsan is effective for the treatment of Parkinsonian tremors and is similar in action to, but more potent than, biperiden. It exhibits use-dependent, open channel, uncompetitive NMDA receptor antagonistic activity. This may occur by binding to the PCP site in addition to interacting with sigma, binding sites in the frontal cortex. Parkinsan is also an antagonist at presynaptic muscarinic autoreceptors but facilitation of direct or indirect dopaminergic transmission does not contribute to its actions. While its mechanism of action is not completely understood, it has a weak inhibitory effect on dopamine reuptake, inhibits evoked GABA release (with low affinity for GABA-A receptors and a lower affinity for benzodiazepine receptors), and has a weak inhibitory effect on MAO-B.

Originator

Byk Gulden (Germany)

Definition

ChEBI: Budipine is a diarylmethane.

Manufacturing Process

24.4 g of 1-(t-butyl)-4-hydroxy-4-phenylpiperidine are suspended in 150 ml of anhydrous benzene. 61.5 g of finely pulverized anhydrous aluminum chloride are added in portions thereto within 25 min while stirring. The reaction temperature increases on starting addition of aluminum chloride to about 45°C. After about 20 min the temperature is increased to and maintained at about 50° to 55°C for about 1 hour. The resulting reaction solution is cooled to about 20°C and is poured into a mixture of ice and concentrated hydrochloric acid. After warming the mixture to room temperature, the hydrochloric acid layer together with the dark oil formed on decomposition is separated from the benzene layer and is washed with benzene. Water is added to said hydrochloric acid -oil phase, while stirring, in portions and in an amount sufficient to produce an almost clear solution. Said acid solution is rendered alkaline by the addition of 40% sodium hydroxide solution whereby the mixture is well cooled. The alkalized mixture is repeatedly extracted with ether. The combined ether extracts are dried over anhydrous potassium carbonate and are concentrated by evaporation of the ether. 24 g of the crude base are obtained as residue in the form of yellowish oil. A water clear oil boiling at 129-131°C/0.005 mm Hg is recovered by distillation of said crude oil in a high vacuum. The oil solidifies to crystals on standing for a short period of time. After recrystallization from aqueous dimethylformamide, the resulting 1-methyl-4,4-diphenylpiperidine has a melting point of 72-74°C.
Its hydrochloride is produced by dissolving the base in acetic acid ethyl ester and adding an ethereal hydrochloric acid solution thereto. After recrystallization from acetic acid ethyl ester, the melting point of the hydrochloride is 152-154°C.

brand name

Parkinsan

Therapeutic Function

Antiparkinsonian, Antidepressant

BUDIPINE Preparation Products And Raw materials

Raw materials

Preparation Products

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BUDIPINE Suppliers

China 38 Europe 2 Germany 2 India 1 United Kingdom 5 United States 10 Global 58
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Leancare Ltd.
Tel
--
Fax
--
Email
enquiry@leancare.co.uk
Country
United Kingdom
ProdList
6446
Advantage
42
CARBONE SCIENTIFIC CO.,LTD
Tel
--
Fax
--
Email
sales@carbonesci.com
Country
United Kingdom
ProdList
6666
Advantage
30
Glentham Life Sciences
Tel
--
Fax
--
Email
info@glenthamls.com
Country
United Kingdom
ProdList
1429
Advantage
0
Sequoia Research Products Ltd.
Tel
--
Fax
--
Email
sales@seqchem.com
Country
United Kingdom
ProdList
3113
Advantage
69
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View Lastest Price from BUDIPINE manufacturers

Dideu Industries Group Limited
Product
BUDIPINE 57982-78-2
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-26
Career Henan Chemical Co
Product
BUDIPINE 57982-78-2
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-18

57982-78-2, BUDIPINERelated Search:

1,3,5-Tri-tert-butylbenzene Diantimony trioxide Prodipine BUDIPINE 4-N-Methylbenzyl-N-carbethoxypiperidine dihydrochloride

  • BUDIPINE
  • 1-(1,1-dimethylethyl)-4,4-diphenyl-piperidin
  • 1-(1,1-dimethylethyl)-4,4-diphenylpiperidine
  • budipin
  • Piperidine,1-(1,1-dimethylethyl)-4,4-diphenyl-
  • 1-TERT-BUTYL-4,4-DIPHENYL-PIPERIDINE
  • BUDIPINE(FORR&DONLY)
  • 4,4-diphenyl-1-tert-butyl-piperidine
  • BUDIPINE USP/EP/BP
  • monoamine oxidase type B (MAO-B),inhibit,CNS disorders,Parkinson disease,Budipine,Inhibitor,dopaminergic
  • 57982-78-2