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(4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE

Product Name
(4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE
CAS No.
2011-48-5
Chemical Name
(4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE
Synonyms
USAF LA-7;(4-methoxybenzyl)hydrazinium chloride;(4-Methoxybenzyl)hydrazinehydrochloride;(4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE;p-Methoxybenzylhydrazine monohydrochloride;Hydrazine, p-methoxybenzyl-, hydrochloride;[(4-methoxyphenyl)methyl]hydrazine hydrochloride;1-[(4-methoxyphenyl)methyl]hydrazine hydrochloride;(4-methoxyphenyl)methyl]-Hydrazine hydrochloride (1:1);Hydrazine, [(4-Methoxyphenyl)Methyl]-, hydrochloride (1:1)
CBNumber
CB2369653
Molecular Formula
C8H14Cl2N2O
Formula Weight
225.12
MOL File
2011-48-5.mol
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(4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE Property

Melting point:
194-195℃ (decomposition)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
Pale Yellow to Light Yellow
Stability:
Hygroscopic
InChI
InChI=1S/C8H12N2O.2ClH/c1-11-8-4-2-7(3-5-8)6-10-9;;/h2-5,10H,6,9H2,1H3;2*1H
InChIKey
XMPHUNHAMDBTBE-UHFFFAOYSA-N
SMILES
C1C(OC)=CC=C(CNN)C=1.Cl.Cl
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Safety

HazardClass 
IRRITANT
HS Code 
2928009090
Toxicity
mouse,LD50,intraperitoneal,50mg/kg (50mg/kg),National Technical Information Service. Vol. AD277-689,
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M331173
Product name
(4-Methoxybenzyl)hydrazineHydrochloride
Packaging
500mg
Price
$40
Updated
2021/12/16
TRC
Product number
M331173
Product name
(4-Methoxybenzyl)hydrazineHydrochloride
Packaging
5g
Price
$55
Updated
2021/12/16
Ark Pharm
Product number
AK-33977
Product name
(4-Methoxybenzyl)hydrazinehydrochloride
Purity
97%
Packaging
25g
Price
$56
Updated
2021/12/16
Matrix Scientific
Product number
074107
Product name
(4-Methoxybenzyl)hydrazine hydrochloride
Purity
95+%
Packaging
1g
Price
$98
Updated
2021/12/16
Apolloscientific
Product number
OR55590
Product name
4-Methoxybenzylhydrazinehydrochloride
Purity
97%
Packaging
5g
Price
$145
Updated
2021/12/16
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(4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE Chemical Properties,Usage,Production

Uses

(4-Methoxybenzyl)hydrazine Hydrochloride is used in preparation of Heterocyclic derivatives useful as SHP2 inhibitors.

Synthesis

824-94-2

2011-48-5

Step 1: Synthesis of (4-methoxybenzyl)hydrazine hydrochloride Hydrazine hydrate (40 g, 0.80 mol) and anhydrous ethanol (280 mL) were added to a 500 mL three-necked round bottom flask. A solution of anhydrous ethanol (30 mL) of 4-methoxybenzyl chloride (12.5 g, 0.080 mol) was slowly added dropwise to the above mixture at room temperature. The reaction mixture was heated to 90 °C and stirred for 2 hours. Upon completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent and the residue was subsequently redissolved in anhydrous ethanol (150 mL). The solution was cooled to 0 °C and acidified by slowly adding 5 M hydrochloric acid (120 mL). The precipitated white solid precipitate was collected by filtration and dried to give 8.72 g of the target product (4-methoxybenzyl)hydrazine hydrochloride in 72% yield. Mass spectrometry analysis showed m/z: 153(M+H)+.

References

[1] Patent: US2010/120741, 2010, A1. Location in patent: Page/Page column 87
[2] Patent: WO2011/112731, 2011, A2. Location in patent: Page/Page column 189-190
[3] Patent: WO2014/139150, 2014, A1. Location in patent: Page/Page column 84; 85
[4] Patent: WO2014/150114, 2014, A1. Location in patent: Page/Page column 84; 85
[5] Patent: US2017/145026, 2017, A1. Location in patent: Paragraph 1027; 1028

(4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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(4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE Suppliers

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View Lastest Price from (4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
(4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE 2011-48-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-25
Hebei Yanxi Chemical Co., Ltd.
Product
(4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE 2011-48-5
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-11-08
Career Henan Chemical Co
Product
(4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE 2011-48-5
Price
US $500.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2018-08-04

2011-48-5, (4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDERelated Search:

(R)-1-(TERT-BUTOXYCARBONYL)-3-PIPERIDINECARBOXALDEHYDE tert-Butyl (4-methylpiperidin-4-yl)carbamate tert-butyl (R)-3-formylpyrrolidine-1-carboxylate 2,3-DICHLORO-5,8-DIHYDROXY-1,4-NAPHTHOQUINONE tert-butyl N-(5-cyano-1,3-thiazol-2-yl)carbamate Hydrazine dihydrochloride

  • [(4-methoxyphenyl)methyl]hydrazine hydrochloride
  • Hydrazine, p-methoxybenzyl-, hydrochloride
  • p-Methoxybenzylhydrazine monohydrochloride
  • (4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE
  • Hydrazine, [(4-Methoxyphenyl)Methyl]-, hydrochloride (1:1)
  • USAF LA-7
  • (4-Methoxybenzyl)hydrazinehydrochloride
  • (4-methoxybenzyl)hydrazinium chloride
  • (4-methoxyphenyl)methyl]-Hydrazine hydrochloride (1:1)
  • 1-[(4-methoxyphenyl)methyl]hydrazine hydrochloride
  • 2011-48-5