tert-Butyl (4-methylpiperidin-4-yl)carbamate
- Product Name
- tert-Butyl (4-methylpiperidin-4-yl)carbamate
- CAS No.
- 163271-08-7
- Chemical Name
- tert-Butyl (4-methylpiperidin-4-yl)carbamate
- Synonyms
- 4-(Boc-amino)-4-methylpip...;4-Methylpiperidin-4-yl)carbami;4-(Boc-aMino)-4-Methylpiperidine;tert-Butyl (4-methylpiperidin-4-yl);4-Amino-4-methylpiperidine, 4-BOC protected;tert-Butyl N-(4-Methyl-4-piperidyl)carbaMate;tert-Butyl (4-methylpiperidin-4-yl)carbamate;tert-Butyl (4-methyl-4-piperidinyl)carbamate;tert-butyl N-(4-methylpiperidin-4-yl)carbamate;N-(4-Methylpiperidin-1-yl)(tert-butoxy)forMaMide
- CBNumber
- CB81501982
- Molecular Formula
- C11H22N2O2
- Formula Weight
- 214.3
- MOL File
- 163271-08-7.mol
tert-Butyl (4-methylpiperidin-4-yl)carbamate Property
- Boiling point:
- 308 °C
- Density
- 1.01
- Flash point:
- 140 °C
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 12.75±0.20(Predicted)
- form
- powder
- color
- Gray
- InChI
- InChI=1S/C11H22N2O2/c1-10(2,3)15-9(14)13-11(4)5-7-12-8-6-11/h12H,5-8H2,1-4H3,(H,13,14)
- InChIKey
- MVUNGZMGWJXPIM-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)NC1(C)CCNCC1
Safety
- HS Code
- 2933399990
N-Bromosuccinimide Price
- Product number
- T206020
- Product name
- tert-Butyl(4-Methylpiperidin-4-yl)carbamate
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 4H51-1-39
- Product name
- 4-Amino-4-methylpiperidine, 4-Boc protected
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FB144287
- Product name
- tert-Butyl (4-methylpiperidin-4-yl)carbamate
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- W3558
- Product name
- (4-Methylpiperidin-4-yl)carbamicacidtert-butylester
- Packaging
- 1g
- Price
- $112
- Updated
- 2021/12/16
- Product number
- FB144287
- Product name
- tert-Butyl (4-methylpiperidin-4-yl)carbamate
- Packaging
- 2g
- Price
- $160
- Updated
- 2021/12/16
tert-Butyl (4-methylpiperidin-4-yl)carbamate Chemical Properties,Usage,Production
Uses
tert-Butyl (4-methylpiperidin-4-yl)carbamate is versatile intermediates in organic synthesis, particularly in the pharmaceutical industry. They are used in the synthesis of various compounds, including natural products and potential therapeutic agents.
Synthesis
1262787-56-3
163271-08-7
General procedure for the synthesis of tert-butyl (4-methylpiperidin-4-yl)carbamate from (1-benzoyl-4-methylpiperidin-4-yl)carbamate: 1. tert-Butyl (1-benzoyl-4-methylpiperidin-4-yl)carbamate (318 mg, 1.0 mmol) was dissolved in ethanol (3 mL). 2. 6 N aqueous sodium hydroxide (1.0 mL, 6.0 mmol) was added to the above solution. 3. The reaction mixture was heated at reflux for 8 hours. 4. 4. Upon completion of the reaction, the mixture was concentrated under reduced pressure. 5. Ethyl acetate (30 mL) was added to the concentrated mixture. 6. The organic layer was separated and washed twice with distilled water. 7. Dry the organic layer with anhydrous magnesium sulfate. 8. Concentrate the dried organic layer under reduced pressure and dry under reduced pressure to afford the target product tert-butyl (4-methylpiperidin-4-yl)carbamate (145 mg, 0.67 mmol, 67% yield). Characterization data: Mass spectrum (EI, m/z): 214 [M]+. 1H-NMR (CDCl3) δ: 4.37 (1H, br s), 2.84-2.80 (4H, m), 1.91 (2H, dt, J = 13.3, 3.9 Hz), 1.51 (2H, td, J = 12.9, 6.2 Hz), 1.44 (9H, s), 1.34 (3H, s).
References
[1] Patent: US2012/149902, 2012, A1. Location in patent: Page/Page column 24
tert-Butyl (4-methylpiperidin-4-yl)carbamate Preparation Products And Raw materials
Raw materials
Preparation Products
tert-Butyl (4-methylpiperidin-4-yl)carbamate Suppliers
- Tel
- 025-58859352 18068836627
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 15083
- Advantage
- 58
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2922
- Advantage
- 55
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12000
- Advantage
- 60
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 15883
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- +86 (21) 6435-5022
- Country
- China
- ProdList
- 4267
- Advantage
- 65
- Tel
- 021-61551611 13296011611
- Fax
- ＋86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9895
- Advantage
- 58
- Tel
- 18993966060
- Fax
- 0943-8288977
- sales@techbiochem.com
- Country
- China
- ProdList
- 806
- Advantage
- 61
View Lastest Price from tert-Butyl (4-methylpiperidin-4-yl)carbamate manufacturers
- Product
- tert-Butyl (4-methylpiperidin-4-yl)carbamate 163271-08-7
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2021-09-14
- Product
- tert-Butyl (4-methylpiperidin-4-yl)carbamate 163271-08-7
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10KG
- Release date
- 2021-09-16
- Product
- tert-Butyl (4-methylpiperidin-4-yl)carbamate 163271-08-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2018-08-13