ChemicalBook > CAS DataBase List > tert-Butyl (4-methylpiperidin-4-yl)carbamate

tert-Butyl (4-methylpiperidin-4-yl)carbamate

Product Name: tert-Butyl (4-methylpiperidin-4-yl)carbamate
CAS No.: 163271-08-7
Chemical Name: tert-Butyl (4-methylpiperidin-4-yl)carbamate
Synonyms: 4-(Boc-amino)-4-methylpip...;4-Methylpiperidin-4-yl)carbami;4-(Boc-aMino)-4-Methylpiperidine;tert-Butyl (4-methylpiperidin-4-yl);4-Amino-4-methylpiperidine, 4-BOC protected;tert-Butyl N-(4-Methyl-4-piperidyl)carbaMate;tert-Butyl (4-methylpiperidin-4-yl)carbamate;tert-Butyl (4-methyl-4-piperidinyl)carbamate;tert-butyl N-(4-methylpiperidin-4-yl)carbamate;N-(4-Methylpiperidin-1-yl)(tert-butoxy)forMaMide
CBNumber: CB81501982
Molecular Formula: C11H22N2O2
Formula Weight: 214.3
MOL File: 163271-08-7.mol

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tert-Butyl (4-methylpiperidin-4-yl)carbamate Property

Boiling point:: 308 °C
Density: 1.01
Flash point:: 140 °C
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 12.75±0.20(Predicted)
form: powder
color: Gray
InChI: InChI=1S/C11H22N2O2/c1-10(2,3)15-9(14)13-11(4)5-7-12-8-6-11/h12H,5-8H2,1-4H3,(H,13,14)
InChIKey: MVUNGZMGWJXPIM-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NC1(C)CCNCC1

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: T206020
Product name: tert-Butyl(4-Methylpiperidin-4-yl)carbamate
Packaging: 250mg
Price: $45
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H51-1-39
Product name: 4-Amino-4-methylpiperidine, 4-Boc protected
Packaging: 1g
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144287
Product name: tert-Butyl (4-methylpiperidin-4-yl)carbamate
Packaging: 1g
Price: $100
Updated: 2021/12/16

AK Scientific

Product number: W3558
Product name: (4-Methylpiperidin-4-yl)carbamicacidtert-butylester
Packaging: 1g
Price: $112
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144287
Product name: tert-Butyl (4-methylpiperidin-4-yl)carbamate
Packaging: 2g
Price: $160
Updated: 2021/12/16

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tert-Butyl (4-methylpiperidin-4-yl)carbamate Chemical Properties,Usage,Production

Uses

tert-Butyl (4-methylpiperidin-4-yl)carbamate is versatile intermediates in organic synthesis, particularly in the pharmaceutical industry. They are used in the synthesis of various compounds, including natural products and potential therapeutic agents.

Synthesis

1262787-56-3

163271-08-7

General procedure for the synthesis of tert-butyl (4-methylpiperidin-4-yl)carbamate from (1-benzoyl-4-methylpiperidin-4-yl)carbamate: 1. tert-Butyl (1-benzoyl-4-methylpiperidin-4-yl)carbamate (318 mg, 1.0 mmol) was dissolved in ethanol (3 mL). 2. 6 N aqueous sodium hydroxide (1.0 mL, 6.0 mmol) was added to the above solution. 3. The reaction mixture was heated at reflux for 8 hours. 4. 4. Upon completion of the reaction, the mixture was concentrated under reduced pressure. 5. Ethyl acetate (30 mL) was added to the concentrated mixture. 6. The organic layer was separated and washed twice with distilled water. 7. Dry the organic layer with anhydrous magnesium sulfate. 8. Concentrate the dried organic layer under reduced pressure and dry under reduced pressure to afford the target product tert-butyl (4-methylpiperidin-4-yl)carbamate (145 mg, 0.67 mmol, 67% yield). Characterization data: Mass spectrum (EI, m/z): 214 [M]+. 1H-NMR (CDCl3) δ: 4.37 (1H, br s), 2.84-2.80 (4H, m), 1.91 (2H, dt, J = 13.3, 3.9 Hz), 1.51 (2H, td, J = 12.9, 6.2 Hz), 1.44 (9H, s), 1.34 (3H, s).

References

[1] Patent: US2012/149902, 2012, A1. Location in patent: Page/Page column 24

tert-Butyl (4-methylpiperidin-4-yl)carbamate Preparation Products And Raw materials

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View Lastest Price from tert-Butyl (4-methylpiperidin-4-yl)carbamate manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: tert-Butyl (4-methylpiperidin-4-yl)carbamate 163271-08-7
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2021-09-14

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: tert-Butyl (4-methylpiperidin-4-yl)carbamate 163271-08-7
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10KG
Release date: 2021-09-16

Career Henan Chemical Co

Product: tert-Butyl (4-methylpiperidin-4-yl)carbamate 163271-08-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20kg
Release date: 2018-08-13

163271-08-7, tert-Butyl (4-methylpiperidin-4-yl)carbamateRelated Search:

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4-Methylpiperidin-4-yl)carbami

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tert-Butyl (4-methylpiperidin-4-yl)carbamate

4-(Boc-amino)-4-methylpip...

4-(Boc-aMino)-4-Methylpiperidine

tert-Butyl N-(4-Methyl-4-piperidyl)carbaMate

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tert-Butyl (4-methylpiperidin-4-yl)carbamate, 4-[(tert-Butoxycarbonyl)amino]-4-methylpiperidine

CarbaMic acid, N-(4-Methyl-4-piperidinyl)-, 1,1-diMethylethyl ester

tert-butyl N-(4-methylpiperidin-4-yl)carbamate

tert-Butyl (4-methylpiperidin-4-yl)

1,1-Dimethylethyl N-(4-methyl-4-piperidinyl)carbamate

163271-08-7

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