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1-INDOLEPROPIONIC ACID

Product Name
1-INDOLEPROPIONIC ACID
CAS No.
6639-06-1
Chemical Name
1-INDOLEPROPIONIC ACID
Synonyms
1-INDOLEPROPIONIC ACID;Indole-1-propionic acid;B-N-INDOLEPROPIONIC ACID;1H-indole-1-propanoic acid;3-indol-1-ylpropionic acid;3-indol-1-ylpropanoic acid;3-(1-indolyl)propanoic acid;BETA-N-INDOLE PROPIONIC ACID;3-(1H-INDOL-1-YL)PROPANOIC ACID
CBNumber
CB2379252
Molecular Formula
C11H11NO2
Formula Weight
189.21
MOL File
6639-06-1.mol
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1-INDOLEPROPIONIC ACID Property

Melting point:
91 °C
Boiling point:
180-197 °C
Density 
1.19±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
4.59±0.10(Predicted)
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Safety

HazardClass 
IRRITANT
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S540390
Product name
1-INDOLEPROPIONIC ACID
Purity
Aldrich<sup>CPR</sup>
Packaging
1 unit
Price
$185
Updated
2025/07/31
Sigma-Aldrich
Product number
S540390
Product name
1-INDOLEPROPIONIC ACID
Purity
AldrichCPR
Packaging
1G
Price
$179
Updated
2024/03/01
AK Scientific
Product number
Z5006
Product name
3-(1H-Indol-1-yl)propanoicacid
Packaging
10g
Price
$611
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0118689
Product name
1-INDOLEPROPIONIC ACID
Purity
95.00%
Packaging
1G
Price
$648.81
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0118689
Product name
1-INDOLEPROPIONIC ACID
Purity
95.00%
Packaging
2.5G
Price
$852.21
Updated
2021/12/16
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1-INDOLEPROPIONIC ACID Chemical Properties,Usage,Production

Synthesis

120-72-9

3395-91-3

6639-06-1

General procedure for the synthesis of 1-indolepropionic acid from indole and methyl 3-bromopropionate: Synthesis of 3-(1H-indol-1-yl)propionic acid (Intermediate-25): 10 mL of DMF was added to a 100 mL round bottom flask fitted with a magnetic stirrer. to the stirred solvent was added indole (1.0 g, 8.53 mmol) followed by sodium hydride (400 mg, 10.24 mmol). The resulting mixture was stirred at room temperature for 1 hr. Methyl 3-bromopropionate (2.13 g, 12.79 mmol) was added to the above reaction solution and stirring was continued for 24 hours at room temperature. After completion of the reaction (the progress of the reaction was monitored by TLC), the reaction mixture was diluted with 30 mL of ice water and washed with ether. The aqueous phase was acidified with 1N HCl to pH=2 and subsequently extracted with EtOAc and concentrated to give Intermediate-24 (900 mg).

References

[1] Patent: WO2013/128465, 2013, A1. Location in patent: Page/Page column 94
[2] Patent: US2015/158860, 2015, A1. Location in patent: Paragraph 0332
[3] Patent: WO2004/43899, 2004, A1. Location in patent: Page 37; 38

1-INDOLEPROPIONIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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1-INDOLEPROPIONIC ACID Suppliers

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