ChemicalBook > CAS DataBase List > 3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE

3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE

Product Name: 3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE
CAS No.: 40254-90-8
Chemical Name: 3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE
Synonyms: NSC 693868;Brimonidine Impurity 8;Cdk1/5 Inhibitor inhibitor;3-Aminopyrazolo[3,4-b]quinoxaline;1H-PYRAZOLO[3,4-B]QUINOXALIN-3-AMINE;3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE;1H-Pyrazolo[3,4-b]quinoxalin-3-ylamine;1H-Pyrazolo[3,4-b]quinoxalin-3-amine(9CI);Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem
CBNumber: CB2381002
Molecular Formula: C9H7N5
Formula Weight: 185.19
MOL File: 40254-90-8.mol

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3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Property

Melting point:: 292-293℃ (ethanol )
Boiling point:: 522.8±45.0 °C(Predicted)
Density: 1.570±0.06 g/cm3(Predicted)
storage temp.: Store at +4°C
solubility: Soluble to 100 mM in DMSO
form: Red solid
pka: 7.40±0.50(Predicted)
color: Orange to red

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 217720
Product name: Cdk1/5 Inhibitor
Packaging: 5mg
Price: $238
Updated: 2023/01/07

Cayman Chemical

Product number: 18740
Product name: Cdk1/5 Inhibitor
Purity: ≥95%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 18740
Product name: Cdk1/5 Inhibitor
Purity: ≥95%
Packaging: 5mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 18740
Product name: Cdk1/5 Inhibitor
Purity: ≥95%
Packaging: 10mg
Price: $216
Updated: 2024/03/01

TRC

Product number: N900555
Product name: NSC693868
Packaging: 10mg
Price: $180
Updated: 2021/12/16

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3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Chemical Properties,Usage,Production

Description

Cyclin-dependent kinases (Cdks) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. Cdk1/5 Inhibitor is a pyrazolo [3,4-b] quioxaline that inhibits Cdk1/cyclin B and Cdk5/p25 (IC₅₀s = 600 and 400 nM, respectively). It less potently inhibits GSK3β (IC₅₀ = 1 μM) and does not block Cdc25 activity. This compound is used to help define the roles of Cdk1 and Cdk5 in various signaling pathways.

Uses

Cyclin-dependent kinases (CDKs) are protein kinases and involved with the regulation of the cell cycle. NSC 693868 is an inhibitor of Cdk1/cyclin B and Cdk5/p25.?Small molecules that target these protein kinases are valuable tools for investigating cellular signaling pathways and are potential therapeutic agents.

Definition

ChEBI: 2H-pyrazolo[4,3-b]quinoxalin-3-amine is a quinoxaline derivative.

Biological Activity

Inhibitor of cyclin-dependent kinases (cdks) and glycogen synthase kinase-3 (GSK-3). IC 50 values are 0.6, 0.4 and 1 μ M for cdk1/cyclin B, cdk5/p25 and GSK-3 respectively.

IC 50

Cdk1/cyclin B: 600 nM (IC₅₀); Cdk5/p25: 400 nM (IC₅₀); GSK-3β: 1 μM (IC₅₀)

References

[1] MIGUEL A. ORTEGA . Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-Dependent kinases inhibitors[J]. Bioorganic & Medicinal Chemistry, 2002, 10 7: Pages 2177-2184. DOI: 10.1016/s0968-0896(02)00069-x
[2] SHAOYONG CHEN. Androgen receptor phosphorylation and stabilization in prostate cancer by cyclin-dependent kinase 1.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2006, 103 43: 15969-15974. DOI: 10.1073/pnas.0604193103
[3] TRI K NGUYEN Steven G. Dinaciclib (SCH727965) inhibits the unfolded protein response through a CDK1- and 5-dependent mechanism.[J]. Molecular Cancer Therapeutics, 2014: 662-674. DOI: 10.1158/1535-7163.mct-13-0714
[4] SUPACHAI TOPANURAK. High NaCl- and urea-induced posttranslational modifications that increase glycerophosphocholine by inhibiting GDPD5 phosphodiesterase.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2013: 7482-7487. DOI: 10.1073/pnas.1305220110

3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Suppliers

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40254-90-8, 3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINERelated Search:

Brimonidine Impurity 6 Sodium Salt 5-Bromoquinazolin-6-ylthiourea 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine BriMonidine-2,3-dione Brimonidine Impurity 7 Brimonidine Related Impurity 3 1H-PYRAZOLO[3,4-B]PYRAZIN-3-AMINE 4,7-DIAZA-1H-INDAZOLE 3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE

1H-PYRAZOLO[3,4-B]QUINOXALIN-3-AMINE

3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE

NSC 693868

1H-Pyrazolo[3,4-b]quinoxalin-3-amine(9CI)

3-Aminopyrazolo[3,4-b]quinoxaline

1H-Pyrazolo[3,4-b]quinoxalin-3-ylamine

Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem

Brimonidine Impurity 8

Cdk1/5 Inhibitor inhibitor

40254-90-8

C9H7N5

Protein Kinase

PIPERIDINE