ChemicalBook > CAS DataBase List > 3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE

3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE

Product Name
3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE
CAS No.
40254-90-8
Chemical Name
3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE
Synonyms
NSC 693868;Brimonidine Impurity 8;Cdk1/5 Inhibitor inhibitor;3-Aminopyrazolo[3,4-b]quinoxaline;1H-PYRAZOLO[3,4-B]QUINOXALIN-3-AMINE;3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE;1H-Pyrazolo[3,4-b]quinoxalin-3-ylamine;1H-Pyrazolo[3,4-b]quinoxalin-3-amine(9CI);Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem
CBNumber
CB2381002
Molecular Formula
C9H7N5
Formula Weight
185.19
MOL File
40254-90-8.mol
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3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Property

Melting point:
292-293℃ (ethanol )
Boiling point:
522.8±45.0 °C(Predicted)
Density 
1.570±0.06 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
Soluble to 100 mM in DMSO
form 
Red solid
pka
7.40±0.50(Predicted)
color 
Orange to red
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
217720
Product name
Cdk1/5 Inhibitor
Packaging
5mg
Price
$238
Updated
2023/01/07
Cayman Chemical
Product number
18740
Product name
Cdk1/5 Inhibitor
Purity
≥95%
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
18740
Product name
Cdk1/5 Inhibitor
Purity
≥95%
Packaging
5mg
Price
$120
Updated
2024/03/01
Cayman Chemical
Product number
18740
Product name
Cdk1/5 Inhibitor
Purity
≥95%
Packaging
10mg
Price
$216
Updated
2024/03/01
TRC
Product number
N900555
Product name
NSC693868
Packaging
10mg
Price
$180
Updated
2021/12/16
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3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Chemical Properties,Usage,Production

Description

Cyclin-dependent kinases (Cdks) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. Cdk1/5 Inhibitor is a pyrazolo [3,4-b] quioxaline that inhibits Cdk1/cyclin B and Cdk5/p25 (IC50s = 600 and 400 nM, respectively). It less potently inhibits GSK3β (IC50 = 1 μM) and does not block Cdc25 activity. This compound is used to help define the roles of Cdk1 and Cdk5 in various signaling pathways.

Uses

Cyclin-dependent kinases (CDKs) are protein kinases and involved with the regulation of the cell cycle. NSC 693868 is an inhibitor of Cdk1/cyclin B and Cdk5/p25.?Small molecules that target these protein kinases are valuable tools for investigating cellular signaling pathways and are potential therapeutic agents.

Definition

ChEBI: 2H-pyrazolo[4,3-b]quinoxalin-3-amine is a quinoxaline derivative.

Biological Activity

Inhibitor of cyclin-dependent kinases (cdks) and glycogen synthase kinase-3 (GSK-3). IC 50 values are 0.6, 0.4 and 1 μ M for cdk1/cyclin B, cdk5/p25 and GSK-3 respectively.

3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Suppliers

China 33 Europe 1 Germany 2 India 1 Switzerland 1 United Kingdom 1 United States 11 USA 1 Global 51
3B Pharmachem (Wuhan) International Co.,Ltd.
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40254-90-8, 3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINERelated Search:

Brimonidine Impurity 6 Sodium Salt 5-Bromoquinazolin-6-ylthiourea 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine BriMonidine-2,3-dione Brimonidine Impurity 7 Brimonidine Related Impurity 3 1H-PYRAZOLO[3,4-B]PYRAZIN-3-AMINE 4,7-DIAZA-1H-INDAZOLE 3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE

  • 1H-PYRAZOLO[3,4-B]QUINOXALIN-3-AMINE
  • 3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE
  • NSC 693868
  • 1H-Pyrazolo[3,4-b]quinoxalin-3-amine(9CI)
  • 3-Aminopyrazolo[3,4-b]quinoxaline
  • 1H-Pyrazolo[3,4-b]quinoxalin-3-ylamine
  • Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem
  • Brimonidine Impurity 8
  • Cdk1/5 Inhibitor inhibitor
  • 40254-90-8
  • C9H7N5
  • Protein Kinase
  • PIPERIDINE