3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE
- Product Name
- 3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE
- CAS No.
- 40254-90-8
- Chemical Name
- 3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE
- Synonyms
- NSC 693868;Brimonidine Impurity 8;Cdk1/5 Inhibitor inhibitor;3-Aminopyrazolo[3,4-b]quinoxaline;1H-PYRAZOLO[3,4-B]QUINOXALIN-3-AMINE;3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE;1H-Pyrazolo[3,4-b]quinoxalin-3-ylamine;1H-Pyrazolo[3,4-b]quinoxalin-3-amine(9CI);Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem
- CBNumber
- CB2381002
- Molecular Formula
- C9H7N5
- Formula Weight
- 185.19
- MOL File
- 40254-90-8.mol
3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Property
- Melting point:
- 292-293℃ (ethanol )
- Boiling point:
- 522.8±45.0 °C(Predicted)
- Density
- 1.570±0.06 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- Soluble to 100 mM in DMSO
- form
- Red solid
- pka
- 7.40±0.50(Predicted)
N-Bromosuccinimide Price
- Product number
- 217720
- Product name
- Cdk1/5 Inhibitor
- Packaging
- 5mg
- Price
- $238
- Updated
- 2023/01/07
- Product number
- 18740
- Product name
- Cdk1/5 Inhibitor
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 18740
- Product name
- Cdk1/5 Inhibitor
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- 18740
- Product name
- Cdk1/5 Inhibitor
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $216
- Updated
- 2024/03/01
- Product number
- N900555
- Product name
- NSC693868
- Packaging
- 10mg
- Price
- $180
- Updated
- 2021/12/16
3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Chemical Properties,Usage,Production
Description
Cyclin-dependent kinases (Cdks) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. Cdk1/5 Inhibitor is a pyrazolo [3,4-b] quioxaline that inhibits Cdk1/cyclin B and Cdk5/p25 (IC50s = 600 and 400 nM, respectively). It less potently inhibits GSK3β (IC50 = 1 μM) and does not block Cdc25 activity. This compound is used to help define the roles of Cdk1 and Cdk5 in various signaling pathways.
Uses
Cyclin-dependent kinases (CDKs) are protein kinases and involved with the regulation of the cell cycle. NSC 693868 is an inhibitor of Cdk1/cyclin B and Cdk5/p25.?Small molecules that target these protein kinases are valuable tools for investigating cellular signaling pathways and are potential therapeutic agents.
Definition
ChEBI: 2H-pyrazolo[4,3-b]quinoxalin-3-amine is a quinoxaline derivative.
Biological Activity
Inhibitor of cyclin-dependent kinases (cdks) and glycogen synthase kinase-3 (GSK-3). IC 50 values are 0.6, 0.4 and 1 μ M for cdk1/cyclin B, cdk5/p25 and GSK-3 respectively.