ChemicalBook > CAS DataBase List > GOSSYPIN

GOSSYPIN

Product Name: GOSSYPIN
CAS No.: 652-78-8
Chemical Name: GOSSYPIN
Synonyms: GOSSYPIN;Nsc656276;Aids032470;Aids-032470;Gossypin-RM;Gossypin 85%;,7-trihydroxy-;COTTON CELLULOSE;GOSSYPIN(P)(CALL);GOSSYPIN(RG) 10mg
CBNumber: CB2385161
Molecular Formula: C21H20O13
Formula Weight: 480.38
MOL File: 652-78-8.mol

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GOSSYPIN Property

Melting point:: 229-230°C
Boiling point:: 886.0±65.0 °C(Predicted)
Density: 1.883±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: -20°C
solubility: DMSO: soluble15mg/mL, clear
form: powder
pka: 5.70±0.40(Predicted)
color: light yellow to dark green-yellow
LogP: -1.320 (est)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-62-37/38-36-22
Safety Statements: 26-36-37
WGK Germany: 3
RTECS: DJ3009900
HS Code: 2938909090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89695
Product name: Gossypin
Purity: phyproof<SUP>®</SUP> Reference Substance
Packaging: 20 mg
Price: $273
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0761
Product name: Gossypin
Purity: ≥90% (HPLC)
Packaging: 50mg
Price: $104
Updated: 2023/06/20

TRC

Product number: G767903
Product name: Gossypin
Packaging: 100mg
Price: $285
Updated: 2021/12/16

Usbiological

Product number: 293684
Product name: Gossypin
Packaging: 500mg
Price: $460
Updated: 2021/12/16

ChemScene

Product number: CS-0102990
Product name: Gossypin
Packaging: 5mg
Price: $130
Updated: 2021/12/16

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GOSSYPIN Chemical Properties,Usage,Production

Uses

antiinflammatory, antiangiogenesis, antineoplastic, inhibits NF-kB cell response

Definition

ChEBI: A glycosyloxyflavone that is gossypetin attached to a beta-D-glucopyranosyl residue at position 8 via a glycosidic linkage.

Biological Activity

Gossypin is an anti-inflammatory pentahydroxyflavone glucoside isolated from Hibiscus vitifolius th at is used as an herbal remedy for diabetes, jaundice, and inflammation. Gossypin potently inhibits human cancer cell proliferation, including melanoma and glioma cells. Gossypin directly binds and inhibits BRAFV600E and CDK4 kinases, and also regulates Chk1 and Cdc25C in U251 glioma cells.

in vivo

Gossypin (10-20 mg/kg; p.o.; 30 days) attenuates Isoprenaline (ISO) (HY-108353)-induced ischemic/reperfusion (I/R) in rats via alteration of oxidative stress, inflammatory reaction and gut microbiota^[2].

Animal Model:	Sprague Dawley (SD) rats (200-225 g; male; 8-10 weeks)^[2]
Dosage:	10, 20 mg/kg
Administration:	Oral gavage (p.o.); 30 days
Result:	Reduced the infarct size induced by Isoprenaline (ISO) (HY-108353). Showed the boosted level of LVESP, SW, ESPVR, DP, EDPVR and suppressed level of LVEDP. Increased the bodyweight and suppressed the heart weight and heart/body weight ratio. Suppressed the level of triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL) and increased the level of high-density lipoprotein (HDL). Suppressed the level of nitric oxide synthase (iNOS) and nitric oxide (NO). Decreased the level of MMP-2 and MMP-9. Suppressed the level of inflammatory cytokines (TNF-α, IL-1β, IL-6) and decreased the level of NF-κB in the serum and heart tissue. Suppressed the apoptosis of muscle fibres with edema and necrosis.

GOSSYPIN Preparation Products And Raw materials

Raw materials

Preparation Products

Hydroxypropyl methyl cellulose

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GOSSYPIN Suppliers

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View Lastest Price from GOSSYPIN manufacturers

R&D Scientific Inc.

Product: Gossypin 652-78-8
Price: US $890.00/g
Min. Order: 1g
Purity: 97
Supply Ability: 500 Kg
Release date: 2024-03-31

652-78-8, GOSSYPINRelated Search:

3',4',7,8-TETRAHYDROXYFLAVONE 2',5'-Dihydroxyacetophenone 2',3',4'-TRIHYDROXYACETOPHENONE 2'-Hydroxy-5'-methoxyacetophenone GOSSYPIN Ethyl vanillin Homovanillyl alcohol 4-Butoxyphenol Wogonin Eugenol 3-(METHOXYMETHOXY)BENZALDEHYDE 3-Ethoxyacetophenone 3-(2-HYDROXYETHOXY)BENZALDEHYDE 2-Propoxyphenol Quercetin 2',3'-DIMETHOXYACETOPHENONE 2-(2-Methoxyphenoxy)ethanol AKOS B000301

3,3',4',5,7,8-HEXAHYDROXYFLAVONE 8-GLUCOSIDE

3,3',4',5,7-PENTAHYDROXY-8-O-GLUCOSYLFLAVONE

GOSSYPIN

,7-trihydroxy-

2-(3,4-dihydroxyphenyl)-8-(beta-d-glucopyranosyloxy)-3,5,7-trihydroxy-4h-1-b

4h-1-benzopyran-4-one,2-(3,4-dihydroxyphenyl)-8-(beta-d-glucopyranosyloxy)-3,5

gossypin from hibiscus vitifolius*flowers

COTTON CELLULOSE

gossypetin-8-glucoside

8-[(β-D-Glucopyranosyl)oxy]-3,3',4',5,7-pentahydroxyflavone

4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-8-(.beta.-D-glucopyranosyloxy)-3,5,7-trihydroxy-

Aids032470

Aids-032470

Nsc656276

GOSSYPIN(P)(CALL)

2-(3,4-Dihydroxyphenyl)-8-(β-D-glucopyranosyloxy)-3,5,7-trihydroxy- 4H-1-benzopyran-4-one

2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-8-[[3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-1-benzopyran-4-one

4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-8-(β-D-glucopyranosyloxy)-3,5,7-trihydroxy-

2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-8-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one

Antiinflammatory,inhibit,Nuclear factor-κB,Gossypin,Inhibitor,Antioxidant,Anticancer,cardiovascular,osteoclastogenesis,Antiallergic,NF-κB,Nuclear factor-kappaB,Antiviral,Analgesic

Phytochemicals Gossypin

Gossypin 85%

GOSSYPIN(RG) 10mg

Gossypin-RM

Gossypin, Chk1/Cdc25C activator

Gossypin, 10 mM in DMSO

652-78-8

C21H20O13

C28H24O18

Flavanols