2'-Hydroxy-5'-methoxyacetophenone

Product Name: 2'-Hydroxy-5'-methoxyacetophenone
CAS No.: 705-15-7
Chemical Name: 2'-Hydroxy-5'-methoxyacetophenone
Synonyms: 1-(2-HYDROXY-5-METHOXYPHENYL)ETHAN-1-ONE;1-(2-HYDROXY-5-METHOXYPHENYL)ETHANONE;2-HYDROXY-5-METHOXYACETOPHENONE;Ethanone, 1-(2-hydroxy-5-methoxyphenyl)-;2'-Hydro;NSC 338218;ASISCHEM D38760;sulfosulfamic acid;5-Methoxy-2-hydroxyacetophenone;2'-Hydroxy-5'-methoxyacetophene
CBNumber: CB6234562
Molecular Formula: C9H10O3
Formula Weight: 166.17
MOL File: 705-15-7.mol

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2'-Hydroxy-5'-methoxyacetophenone Property

Melting point:: 52 °C(lit.)
Boiling point:: 254.38°C (rough estimate)
Density: 1.1708 (rough estimate)
refractive index: 1.5500 (estimate)
Flash point:: >230 °F
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Crystalline Powder
pka: 10.65±0.18(Predicted)
color: Yellow
Odor: Aromatic, somewhat medicinal, warm, woody -the herbaceous odour of good tenacity.
λmax: 355 nm
BRN: 1239364
InChIKey: MLIBGOFSXXWRIY-UHFFFAOYSA-N
CAS DataBase Reference: 705-15-7(CAS DataBase Reference)
NIST Chemistry Reference: Ethanone, 1-(2-hydroxy-5-methoxyphenyl)-(705-15-7)

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Safety

Hazard Codes: Xi
Risk Statements: 37/38-41-36/37/38
Safety Statements: 26-37/39-36/37/39-22
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29145090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 114995
Product name: 2′-Hydroxy-5′-methoxyacetophenone
Purity: 99%
Packaging: 5g
Price: $47.04
Updated: 2025/07/31

Sigma-Aldrich

Product number: 114995
Product name: 2′-Hydroxy-5′-methoxyacetophenone
Purity: 99%
Packaging: 25g
Price: $81
Updated: 2025/07/31

TCI Chemical

Product number: H0868
Product name: 2'-Hydroxy-5'-methoxyacetophenone
Purity: >98.0%(GC)
Packaging: 5g
Price: $26
Updated: 2025/07/31

TCI Chemical

Product number: H0868
Product name: 2'-Hydroxy-5'-methoxyacetophenone
Purity: >98.0%(GC)
Packaging: 25g
Price: $117
Updated: 2025/07/31

TRC

Product number: H714770
Product name: 2-Hydroxy-5-methoxyacetophenone
Packaging: 25g
Price: $175
Updated: 2021/12/16

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2'-Hydroxy-5'-methoxyacetophenone Chemical Properties,Usage,Production

Chemical Properties

yellow crystalline powder

Uses

2′-Hydroxy-5′-methoxyacetophenone is observed as a side reaction product of elbs persulphate oxidation of phenols. 2-Hydroxy-5-methoxyacetophenone is also used to prepare substituted chromanone and chromone derivatives as sirtuin 2-selective inhibitors.

Application

2'-Hydroxy-5'-methoxyacetophenone could find some use in perfume compositions, e. g., in artificial Oakmoss, in New Mown Hay fragrances, and in certain heavy florals. It blends well with Labdanum and with Lavender type oils, and it lends a certain amount of power and undertones to the fragrance.

Preparation

reparation by reaction of dimethyl sulfate on 2,5-dihydroxyacetophenone, ? with potassium carbonate in acetone at r.t. (74%) ; ? with aqueous sodium hydroxide solution at reflux (35%).

Synthesis Reference(s)

Synthesis, p. 901, 1985 DOI: 10.1055/s-1985-31380

General Description

2′-Hydroxy-5′-methoxyacetophenone is observed as a side reaction product of elbs persulphate oxidation of phenols.

Synthesis

77-78-1

490-78-8

705-15-7

To a suspension of 2,5-dihydroxyacetophenone (100 mg, 0.66 mmol) and potassium carbonate (95 mg, 0.69 mmol) was added dimethyl sulfate (87 mg, 0.69 mmol) and the reaction mixture was stirred at room temperature overnight. After completion of the reaction, the mixture was filtered and concentrated under reduced pressure. The resulting residue was treated with 2N NaOH aqueous solution and subsequently extracted with EtOAc. The organic layers were combined, washed with saturated saline, dried over anhydrous MgSO4 and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with hexane-EtOAc (10:1, v/v) as eluent to afford 2'-hydroxy-5'-methoxyacetophenone in 40% yield as a colorless oil.1H NMR (400 MHz, CDCl3) δ: 11.9 (s, 1H), 7.18 (d, J = 2.8 Hz, 1H), 7.12 (dd, J = 8.8, 2.8 Hz, 1H), 6.93 (d, J = 8.8 Hz, 1H), 3.81 (s, 3H), 2.63 (s, 3H).

References

[1] Journal of the Chinese Chemical Society, 2004, vol. 51, # 6, p. 1389 - 1394
[2] European Journal of Medicinal Chemistry, 2018, vol. 157, p. 1143 - 1152
[3] Journal fuer Praktische Chemie (Leipzig), 1937, vol. <2> 149, p. 324,325
[4] Journal of the Indian Chemical Society, 1990, vol. 67, # 6, p. 478 - 481
[5] European Journal of Medicinal Chemistry, 2009, vol. 44, # 6, p. 2552 - 2562

2'-Hydroxy-5'-methoxyacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-Hydroxy-5'-methoxyacetophenone Suppliers

Americas 1 Austria 1 Belgium 3 Canada 1 China 177 Czech Republic 1 Europe 1 Germany 5 India 34 Japan 4 Slovakia 1 Switzerland 3 The Netherlands 1 Ukraine 2 United Kingdom 15 United States 40 USA 1 Global 291

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View Lastest Price from 2'-Hydroxy-5'-methoxyacetophenone manufacturers

R&D Scientific Inc.

Product: 2'-Hydroxy-5'-methoxyacetophenone 705-15-7
Price: US $950.00/Kg
Min. Order: 1Kg
Purity: 98
Supply Ability: 500 Kg
Release date: 2024-04-23

Career Henan Chemical Co

Product: 2'-Hydroxy-5'-methoxyacetophenone 705-15-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2018-08-09

705-15-7, 2'-Hydroxy-5'-methoxyacetophenoneRelated Search:

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5-Methoxy-2-hydroxyacetophenone

Acetophenone, 2'-hydroxy-5'-methoxy-

1-(2-HYDROXY-5-METHOXYPHENYL)ETHAN-1-ONE

1-(2-HYDROXY-5-METHOXYPHENYL)ETHANONE

2-HYDROXY-5'-METHOXYACETOPHENONE

2-HYDROXY-5-METHOXYACETOPHENONE

2'-HYDROXY-5'-METHOXYACETYLPHENONE

ASISCHEM D38760

2'-Hydroxy-5'-methoxyacetophenone 99%

NSC 338218

2'-HYDROXY-5'-METHOXYACETOPHENONE,99%

2'-Hydro

2'-Hydroxy-5'-methoxyacetophene

JR-6832, 1-(2-Hydroxy-5-methoxyphenyl)ethanone, 97%

sulfosulfamic acid

2'-Hydroxy-5'-methoxyacetophenone&gt

Ethanone, 1-(2-hydroxy-5-methoxyphenyl)-

2'-Hydroxy-5'-methoxyacetophenone

2''-Hydroxy-5''-methoxyacetophenone

2''-Hydroxy-5''-methoxyacetophenone, 10 mM in DMSO

2′-Hydroxy-5′-methoxyacetophenone, CAS 705-15-7

705-15-7

Building Blocks

Carbonyl Compounds

C9

Ketones

Organic Building Blocks

ketone| alcohol

Aromatic Acetophenones & Derivatives (substituted)

C9

Carbonyl Compounds

Ketones