9-CIS-RETINOIC ACID

ChemicalBook > CAS DataBase List > 9-CIS-RETINOIC ACID

9-CIS-RETINOIC ACID

Product Name: 9-CIS-RETINOIC ACID
CAS No.: 5300-03-8
Chemical Name: 9-CIS-RETINOIC ACID
Synonyms: Alitretinoin;Panretin;Tretinoin EP Impurity D;Toctino;LGD 1057;Panretyn;ALRT1057;ALRT 1057;ALRT-1057;NSC 659772
CBNumber: CB2386395
Molecular Formula: C20H28O2
Formula Weight: 300.44
MOL File: 5300-03-8.mol

Less

9-CIS-RETINOIC ACID Property

Melting point:: 189-191°C
Boiling point:: 462.8±14.0 °C(Predicted)
Density: 1.011±0.06 g/cm3(Predicted)
RTECS: VH6450000
storage temp.: -20°C
solubility: Acetonitrile (Very Slightly), Chloroform (Slightly), DMSO (Slightly), Ethanol (
pka: 4.73±0.33(Predicted)
form: Light yellow to orange crystalline powder.
color: Pale Yellow to Yellow
Water Solubility: Soluble in chloroform (50 mg/ml), DMSO (~25 mg/ml), ethanol (25 mg/ml), and acetone (25 mg/ml). Insoluble in water.
Sensitive: Moisture & Light Sensitive
Stability:: Store Dry in Freezer at -20°C for up to 1 year; in Solution at -20°C for up to 3 Months.
CAS DataBase Reference: 5300-03-8(CAS DataBase Reference)

Less

Safety

Hazard Codes: T
Risk Statements: 61-36/37/38
Safety Statements: 53-26-36/37/39-45
WGK Germany: 3
HS Code: 29162090
Hazardous Substances Data: 5300-03-8(Hazardous Substances Data)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R4643
Product name: 9-cis-Retinoic acid
Purity: ≥98% (HPLC)
Packaging: 1MG
Price: $97.2
Updated: 2024/03/01

Alfa Aesar

Product number: J62219
Product name: 9-cis-Retinoic acid
Packaging: 5mg
Price: $226.65
Updated: 2024/03/01

Cayman Chemical

Product number: 14587
Product name: 9-cis-Retinoic Acid
Purity: ≥95%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 14587
Product name: 9-cis-Retinoic Acid
Purity: ≥95%
Packaging: 5mg
Price: $132
Updated: 2024/03/01

Cayman Chemical

Product number: 14587
Product name: 9-cis-Retinoic Acid
Purity: ≥95%
Packaging: 10mg
Price: $238
Updated: 2024/03/01

Less

9-CIS-RETINOIC ACID Chemical Properties,Usage,Production

Description

Alitretinoin was introduced in the US for the topical treatment of cutaneous lesions in patients with Kaposi's sarcoma (KS), the most frequent malignancy observed in AIDS patients. It is a derivative of 9-cis-retinoic acid (9- cis-RA) identified as an endogenous hormone in mammalian tissues. Alitretinoin binds to all isoforms of the intracellular retinoid X (RXR) and retinoid A (RAR) receptors thus inducing cell differentiation, increasing cell apoptosis and inhibiting cellular proliferation in experimental models of human cancer. In an international phase III trial in patients with KS, 42% of 82 patients treated with 0.1% gel formulation experienced complete or partial responses cf 7% for controls. Alitretinoin is the first topical therapy for KS and is expected to be a new option to its traditional management.

Chemical Properties

Pale Yellow Solid

Originator

Ligand (US)

Uses

9-cis-Retinoic acid is a vitamin A analog that inhibits cell proliferation and induces cell differentiation. 9-cis-Retinoic acid is an inhibitor of Cox-2 and an activator of RAR α, RAR β, RAR γ and RXR.

Uses

An endogenous retinoic acid isomer, which is capable of binding to both retinoic acid receptors (RAR) and retinoid X receptors (RXR). A biologically active ligand for members of the RAR and RXR subfamilies, implying that it may play a critical role in regulating retinoid-responsive pathways.

Definition

ChEBI: A retinoic acid in which the exocyclic double bonds have 7E,9Z,11E,13E geometry.

Indications

Alitretinoin (Panretin) is a naturally occurring endogenous retinoid that binds to and activates all known retinoid receptors (both RARs and RXRs). It is approved for the topical treatment of cutaneous lesions of Kaposi’s sarcoma. Most patients have local irritation while using alitretinoin gel; however, the irritation rarely necessitates discontinuation of therapy.

brand name

Panretin (Ligand).

Biochem/physiol Actions

Ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR) that act as transcription factors to regulate the growth and differentiation of normal and malignant cells.

9-CIS-RETINOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

Less

9-CIS-RETINOIC ACID Suppliers

Canada 1 China 120 Germany 3 India 4 Japan 1 Spain 1 Switzerland 2 United Kingdom 5 United States 22 Global 159

Hubei wei shi reagent group ltd., company

Tel: 027-59102966 18717199209
Email: 2853877583@QQ.com
Country: China
ProdList: 7853
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemvon Biotechnology Co., Ltd

Tel: 021-50790412
Fax: +86-21-50790419
Email: info@chemvon.com
Country: China
ProdList: 371
Advantage: 57

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19172
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18738
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Aemon Chemical

Tel: 0086-755-86198205
Email: acinfo@aemonchem.com
Country: China
ProdList: 1931
Advantage: 57

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9658
Advantage: 60

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-4000505016 13380397412
Fax: 0755 28094224
Email: 3001272453@qq.com
Country: China
ProdList: 5047
Advantage: 50

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18042
Advantage: 56

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7887
Advantage: 56

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 16166
Advantage: 55

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9484
Advantage: 50

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Nanjing XiZe Biotechnology CO., Ltd.

Tel: 025-66023220 0086-15250997978
Fax: 025-58362220
Email: 1511893459@qq.com
Country: China
ProdList: 7850
Advantage: 55

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

Taizhou Bolon Pharmachem Co., Ltd.

Tel: 0576-88702850 88702851 88702852
Fax: +86 (576) 8855-9527
Country: China
ProdList: 38
Advantage: 58

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9923
Advantage: 55

Raw material medicin reagent co.,Ltd

Tel
Email: sales@njromanme.com
Country: China
ProdList: 4529
Advantage: 58

Chengdu Dianchun Technology Co., Ltd

Tel: 400-1166-196 18502815961
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Chongqing Chemieliva Pharmaceutical Co., Ltd.

Tel: 023-67770219
Fax: +86 (23) 6777-0220
Email: jessica.hu@chemieliva.com
Country: China
ProdList: 1446
Advantage: 60

Wuhan Wsem Biological Co., Ltd.

Tel: 027-83778876 13667159345
Fax: 027-83778876
Email: 13667159345@163.com
Country: China
ProdList: 1991
Advantage: 55

Wellman Pharmaceutical Group Limited

Tel: 027-027-83778875 15807197853
Fax: 027-83991220
Email: 15807197853@163.com
Country: China
ProdList: 4016
Advantage: 58

Rhawn Reagent

Tel: 400-400-1332688 18019345275
Fax: 400-133-2688
Email: amy@rhawn.cn
Country: China
ProdList: 15497
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 18016230971
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 24969
Advantage: 58

Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.

Tel: 027-51831887 15337167856
Fax: 027-51837635 QQ1165326703
Email: hubeixinyuanshun@163.com
Country: China
ProdList: 10295
Advantage: 58

Shanghai Yinlin Pharmaceutical Co., Ltd.

Tel: 021-33690831
Fax: 021-33690831
Email: 813300142@qq.com
Country: China
ProdList: 305
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52693
Advantage: 58

Beijing OKA biological technology co., LTD

Tel: 010-010-010-62971590 18548936886
Fax: 010-62340519
Email: jack@oka-vip.com
Country: China
ProdList: 6897
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57412
Advantage: 58

Shenzhen Botel Biotechnology Co. Ltd.

Tel: 0755-22202135 13316968096
Email: 1979313431@qq.com
Country: China
ProdList: 8895
Advantage: 58

Guangzhou Belka Biological Technology Co., Ltd.

Tel: +86-18665676617
Fax: 18665676617
Country: China
ProdList: 957
Advantage: 58

TOSUN PHARM

Tel: 020-61855200 13326451905
Email: 260366801@qq.com
Country: China
ProdList: 7781
Advantage: 58

Hebei Mojin Biotechnology Co., Ltd

Tel: +86 13288715578 +8613288715578
Email: sales@hbmojin.com
Country: China
ProdList: 12839
Advantage: 58

Zhengzhou Alfa Chemical Co.,Ltd

Tel: +8618530059196
Email: sale04@alfachem.cn
Country: China
ProdList: 13460
Advantage: 58

Wuhan Golt Biotech Co., Ltd.

Tel: +8615389281203
Email: maria@goltbiotech.com
Country: China
ProdList: 970
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: 571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52849
Advantage: 58

Baoji Guokang Healthchem co.,ltd

Tel: +8615604608665 15604608665
Email: dominicguo@gk-bio.com
Country: CHINA
ProdList: 9414
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15352
Advantage: 58

Shanxi Xuanran Import and Export Trade Co., Ltd.

Tel: +8617735180244
Email: mike_yan@xuanranglobal.com
Country: CHINA
ProdList: 4017
Advantage: 58

Guangzhou Dreampharm Biotechnology Co., Ltd.

Tel: 020-36607679 17825480238
Fax: QQ 3008233717
Email: 3008233717@qq.com
Country: China
ProdList: 9919
Advantage: 12

Hubei Ipure Biology Co., Ltd

Tel: +8613367258412
Fax: 18062427325
Email: ada@ipurechemical.com
Country: China
ProdList: 10319
Advantage: 58

Less

View Lastest Price from 9-CIS-RETINOIC ACID manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: 9-cis-Retinoic Acid 5300-03-8
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-04

Hebei Mojin Biotechnology Co., Ltd

Product: 9-cis-Retinoic Acid 5300-03-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-10-16

Henan Aochuang Chemical Co.,Ltd.

Product: 9-CIS-RETINOIC ACID 5300-03-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-13

5300-03-8, 9-CIS-RETINOIC ACIDRelated Search:

4-KETO 13-CIS-RETINOIC ACID Isotretinoin EP Impurity C 9,13-retinoic acid 11-cis Retinoic Acid Isotretinoin Retinoic acid 9-CIS-RETINOIC ACID 9-CIS-RETINAL 9-cis Retinol 4-Keto 9-cis Retinoic Acid,4-Oxo-9-cis-Retinoic Acid 13-cis-Retinoic Acid b-D-Glucopyranuronic Acid,13-cis-Retinoic Acid -D-Glucopyranuronic Acid 9-cis-Retinoic Acid -D-Glucopyranuronic Acid,9-cis-Retinoic Acid b-D-Glucopyranuronic Acid 9-CIS-RETINOIC ACID METHYL ESTER 4-KETO 13-CIS-RETINOIC ACID METHYL ESTER 13-CIS-RETINOIC ACID METHYL ESTER 9-CIS-RETINOIC ACID--N/H 9-CIS-TRETINOIN = 9-CIS-RETINOIC ACID 13-CIS-RETINOIC ACID--N/H

RETINOIC ACID, 9-CIS-

RARECHEM AL BE 0738

(2E,4E,6Z,8E)-3,7-DIMETHYL-9-(2,6,6-TRIMETHYLCYCLOHEX-1-ENYL)NONA-2,4,6,8-TETRAENOIC ACID

9-CIS-RETINOIC ACID

9-CIS-TRETINOIN

Tretinoin EP Impurity D

(2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex

Isotretinoin Impurity 4（Isotretinoin EP Impurity D）

Tretinoin Impurity 4（Tretinoin EP Impurity D）

Alitretinoin

9-cis-tretinoi

3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-t

ALIRETINOIN

9-cis-Rctinoic Acid

(2E,4E,6Z,8E)-3,7-Dimethyl-9-(2,6,6-Trimethylcyclohex-1-Enyl)Nona-2,4,6,8-Tetraenoic Acid, 9-Cis-Tretinoi

LGD 1057

NSC 659772

Panretin

Panretyn

Toctino

9-cis-Retinoic acid,9-cis-Tretinoin

9-cis-retinoicaci

9-cis retinoic acid (Alitretinoin)

AlitretinoinQ: What is Alitretinoin Q: What is the CAS Number of Alitretinoin Q: What is the storage condition of Alitretinoin Q: What are the applications of Alitretinoin

TIANFU CHEM---9-CIS-RETINOIC ACID

Tretinoin EP Impurity D（Isotretinoin EP Impurity D）

(2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoic acid (9-cis-retinoic acid)

Isotretinoin EP Impurity D（Tretinoin EP Impurity D）

ALRT 1057

ALRT1057

ALRT-1057

(2E,4E,6Z,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid

5300-03-8

5300-3-8

1240-43-1

Cell Biology

Cell Signaling and Neuroscience

BioChemical

PPAR and RXR Regulators

Gene Regulation and Expression

Intermediates & Fine Chemicals

Pharmaceuticals

Retinoids