9-CIS-RETINOIC ACID
- Product Name
- 9-CIS-RETINOIC ACID
- CAS No.
- 5300-03-8
- Chemical Name
- 9-CIS-RETINOIC ACID
- Synonyms
- Alitretinoin;Panretin;Tretinoin EP Impurity D;Toctino;LGD 1057;Panretyn;ALRT1057;ALRT 1057;ALRT-1057;NSC 659772
- CBNumber
- CB2386395
- Molecular Formula
- C20H28O2
- Formula Weight
- 300.44
- MOL File
- 5300-03-8.mol
9-CIS-RETINOIC ACID Property
- Melting point:
- 189-191°C
- Boiling point:
- 462.8±14.0 °C(Predicted)
- Density
- 1.011±0.06 g/cm3(Predicted)
- RTECS
- VH6450000
- storage temp.
- -20°C
- solubility
- Acetonitrile (Very Slightly), Chloroform (Slightly), DMSO (Slightly), Ethanol (
- pka
- 4.73±0.33(Predicted)
- form
- Light yellow to orange crystalline powder.
- color
- Pale Yellow to Yellow
- Water Solubility
- Soluble in chloroform (50 mg/ml), DMSO (~25 mg/ml), ethanol (25 mg/ml), and acetone (25 mg/ml). Insoluble in water.
- Sensitive
- Moisture & Light Sensitive
- Stability:
- Store Dry in Freezer at -20°C for up to 1 year; in Solution at -20°C for up to 3 Months.
- CAS DataBase Reference
- 5300-03-8(CAS DataBase Reference)
Safety
- Hazard Codes
- T
- Risk Statements
- 61-36/37/38
- Safety Statements
- 53-26-36/37/39-45
- WGK Germany
- 3
- HS Code
- 29162090
- Hazardous Substances Data
- 5300-03-8(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H360May damage fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- R4643
- Product name
- 9-cis-Retinoic acid
- Purity
- ≥98% (HPLC)
- Packaging
- 1MG
- Price
- $97.2
- Updated
- 2024/03/01
- Product number
- J62219
- Product name
- 9-cis-Retinoic acid
- Packaging
- 5mg
- Price
- $226.65
- Updated
- 2024/03/01
- Product number
- 14587
- Product name
- 9-cis-Retinoic Acid
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 14587
- Product name
- 9-cis-Retinoic Acid
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $132
- Updated
- 2024/03/01
- Product number
- 14587
- Product name
- 9-cis-Retinoic Acid
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $238
- Updated
- 2024/03/01
9-CIS-RETINOIC ACID Chemical Properties,Usage,Production
Description
Alitretinoin was introduced in the US for the topical treatment of cutaneous lesions in patients with Kaposi's sarcoma (KS), the most frequent malignancy observed in AIDS patients. It is a derivative of 9-cis-retinoic acid (9- cis-RA) identified as an endogenous hormone in mammalian tissues. Alitretinoin binds to all isoforms of the intracellular retinoid X (RXR) and retinoid A (RAR) receptors thus inducing cell differentiation, increasing cell apoptosis and inhibiting cellular proliferation in experimental models of human cancer. In an international phase III trial in patients with KS, 42% of 82 patients treated with 0.1% gel formulation experienced complete or partial responses cf 7% for controls. Alitretinoin is the first topical therapy for KS and is expected to be a new option to its traditional management.
Chemical Properties
Pale Yellow Solid
Originator
Ligand (US)
Uses
9-cis-Retinoic acid is a vitamin A analog that inhibits cell proliferation and induces cell differentiation. 9-cis-Retinoic acid is an inhibitor of Cox-2 and an activator of RAR α, RAR β, RAR γ and RXR.
Uses
An endogenous retinoic acid isomer, which is capable of binding to both retinoic acid receptors (RAR) and retinoid X receptors (RXR). A biologically active ligand for members of the RAR and RXR subfamilies, implying that it may play a critical role in regulating retinoid-responsive pathways.
Definition
ChEBI: A retinoic acid in which the exocyclic double bonds have 7E,9Z,11E,13E geometry.
Indications
Alitretinoin (Panretin) is a naturally occurring endogenous retinoid that binds to and activates all known retinoid receptors (both RARs and RXRs). It is approved for the topical treatment of cutaneous lesions of Kaposi’s sarcoma. Most patients have local irritation while using alitretinoin gel; however, the irritation rarely necessitates discontinuation of therapy.
brand name
Panretin (Ligand).
Biochem/physiol Actions
Ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR) that act as transcription factors to regulate the growth and differentiation of normal and malignant cells.
9-CIS-RETINOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
9-CIS-RETINOIC ACID Suppliers
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View Lastest Price from 9-CIS-RETINOIC ACID manufacturers
- Product
- 9-cis-Retinoic Acid 5300-03-8
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-04
- Product
- 9-cis-Retinoic Acid 5300-03-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-10-16
- Product
- 9-CIS-RETINOIC ACID 5300-03-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-13