ChemicalBook > CAS DataBase List > C188-9

C188-9

Product Name
C188-9
CAS No.
432001-19-9
Chemical Name
C188-9
Synonyms
TTI-101;C188-9;F0808-0084;STAT3 inhibitor TTI-101;C 188-9;C-188-9;C-1889;C1889;C 1889;C-1889;F0808-0084;C188-9; C 188-9; C-188-9; C-1889; C1889; C 1889; C-1889; F0808-0084;N-(1',2-Dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide;N-(1',2-Dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide;N-(1',2-dihydroxy-1.2'-binaphthhalen-4'-yl)-4-methoxybenzene-sulphonamide;Benzenesulfonamide, N-(1',2-dihydroxy[1,2'-binaphthalen]-4'-yl)-4-methoxy-
CBNumber
CB23959200
Molecular Formula
C27H21NO5S
Formula Weight
471.52
MOL File
432001-19-9.mol
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C188-9 Property

Boiling point:
680.9±65.0 °C(Predicted)
Density 
1.416±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml
form 
A crystalline solid
pka
8.14±0.50(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0044737
Product name
C188-9
Purity
99.50%
Packaging
5mg
Price
$100
Updated
2021/12/16
ChemScene
Product number
CS-0044737
Product name
C188-9
Purity
99.50%
Packaging
10mg
Price
$140
Updated
2021/12/16
ChemScene
Product number
CS-0044737
Product name
C188-9
Purity
99.50%
Packaging
25mg
Price
$290
Updated
2021/12/16
ChemScene
Product number
CS-0044737
Product name
C188-9
Purity
99.50%
Packaging
50mg
Price
$460
Updated
2021/12/16
ChemScene
Product number
CS-0044737
Product name
C188-9
Purity
99.50%
Packaging
100mg
Price
$720
Updated
2021/12/16
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C188-9 Chemical Properties,Usage,Production

Biological Activity

C188-9 (TTI 101) is a potent STAT3 inhibitor, binds STAT3 with high affinity, Kd=4.7±0.4 nM. It is well tolerated in mice, has good oral bioavailability, and is mainly enriched in tumor tissues.

in vitro

C188-9 is a small molecule inhibitor of STAT3, targeting the phosphotyrosine peptide binding site in the SH2 region of STAT3 with a Ki value of 136 nM. It does not inhibit upstream Jak or Src kinases.

in vivo

C188-9 inhibited tumor growth in mice bearing UM-SCC-17B xenografts after administration of C188-9. C188-9 was well tolerated in mice, had good oral bioavailability, and was concentrated in tumor tissue after administration.

target

TargetValue
STAT3
(Cell-free)		 4.7 nM(Kd)

C188-9 Preparation Products And Raw materials

Raw materials

Preparation Products

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C188-9 Suppliers

China 64 India 1 United States 5 Global 70
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 17702719238
Email
sales@sun-shinechem.com
Country
China
ProdList
904
Advantage
64
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4654
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3421
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41438
Advantage
60
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2989
Advantage
60
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4153
Advantage
55
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Fax
021-61350662
Email
sales@zehanbiopharma.com
Country
China
ProdList
993
Advantage
55
Shanghai Biolang biotechnology Co.,Ltd
Tel
17764003753
Fax
13669031409
Email
2326587775@qq.com
Country
China
ProdList
188
Advantage
55
Shanghai Biolang biotechnology Co.,Ltd
Tel
17764003753
Fax
13669031409
Email
2326587775@qq.com
Country
China
ProdList
188
Advantage
55
Guangzhou Zhiya Chemdrugs Co.,Ltd
Tel
18122150900
Fax
QQ:2869377561
Email
sculk28@163.com
Country
China
ProdList
646
Advantage
55

432001-19-9, C188-9Related Search:


  • C188-9
  • C 188-9;C-188-9;C-1889;C1889;C 1889;C-1889;F0808-0084
  • N-(1',2-dihydroxy-1.2'-binaphthhalen-4'-yl)-4-methoxybenzene-sulphonamide
  • C188-9; C 188-9; C-188-9; C-1889; C1889; C 1889; C-1889; F0808-0084
  • F0808-0084
  • TTI-101
  • Benzenesulfonamide, N-(1',2-dihydroxy[1,2'-binaphthalen]-4'-yl)-4-methoxy-
  • N-(1',2-Dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide
  • C1889,Apoptosis,STAT,Inhibitor,C188 9,C-188-9,C188-9,TTI101,TTI 101,inhibit
  • STAT3 inhibitor TTI-101
  • N-(1',2-Dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide
  • 432001-19-9