C188-9
- Product Name
- C188-9
- CAS No.
- 432001-19-9
- Chemical Name
- C188-9
- Synonyms
- TTI-101;C188-9;F0808-0084;C188-9, 10 mM in DMSO;STAT3 inhibitor TTI-101;STAT3 Inhibitor XIII, C188-9;C 188-9;C-188-9;C-1889;C1889;C 1889;C-1889;F0808-0084;C188-9; C 188-9; C-188-9; C-1889; C1889; C 1889; C-1889; F0808-0084;N-(1',2-Dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide;N-(1',2-dihydroxy-1.2'-binaphthhalen-4'-yl)-4-methoxybenzene-sulphonamide
- CBNumber
- CB23959200
- Molecular Formula
- C27H21NO5S
- Formula Weight
- 471.52
- MOL File
- 432001-19-9.mol
C188-9 Property
- Boiling point:
- 680.9±65.0 °C(Predicted)
- Density
- 1.416±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml
- form
- A crystalline solid
- pka
- 8.14±0.50(Predicted)
- color
- Off-white to pink
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 573128
- Product name
- STAT3 Inhibitor XIII, C188-9
- Purity
- The Stat3 Inhibitor XIII, C188-9 controls the biological activity of Stat3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
- Packaging
- 10 mg
- Price
- $177
- Updated
- 2025/07/31
- Product number
- CS-0044737
- Product name
- C188-9
- Purity
- 99.50%
- Packaging
- 25mg
- Price
- $290
- Updated
- 2021/12/16
- Product number
- CS-0044737
- Product name
- C188-9
- Purity
- 99.50%
- Packaging
- 10mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- CS-0044737
- Product name
- C188-9
- Purity
- 99.50%
- Packaging
- 5mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CS-0044737
- Product name
- C188-9
- Purity
- 99.50%
- Packaging
- 50mg
- Price
- $460
- Updated
- 2021/12/16
C188-9 Chemical Properties,Usage,Production
Uses
C188-9 (TTI-101) is a STAT3 inhibitor, with a Kd of 4.7 nM. C188-9 inhibits G-CSF-induced STAT3 activation and STAT3-dependent gene expression. C188-9 induces apoptosis in AML cell lines and primary samples and inhibits colony formation by primary AML blasts[1][2][3][4].
Biological Activity
C188-9 (TTI 101) is a potent STAT3 inhibitor, binds STAT3 with high affinity, Kd=4.7±0.4 nM. It is well tolerated in mice, has good oral bioavailability, and is mainly enriched in tumor tissues.
in vitro
C188-9 is a small molecule inhibitor of STAT3, targeting the phosphotyrosine peptide binding site in the SH2 region of STAT3 with a Ki value of 136 nM. It does not inhibit upstream Jak or Src kinases.
in vivo
C188-9 inhibited tumor growth in mice bearing UM-SCC-17B xenografts after administration of C188-9. C188-9 was well tolerated in mice, had good oral bioavailability, and was concentrated in tumor tissue after administration.
target
| Target | Value |
| STAT3 (Cell-free) | 4.7 nM(Kd) |
IC 50
STAT3: 4.7 nM (Kd)
References
[1] Silva KA, et al. Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia. J Biol Chem. 2015 Apr 24;290(17):11177-87. DOI:10.1074/jbc.M115.641514
[2] Redell MS, et al. Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood. 2011 May 26;117(21):5701-9. DOI:10.1182/blood-2010-04-280123
[3] Bharadwaj U, et al. Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget. 2016 May 3;7(18):26307-30. DOI:10.18632/oncotarget.8368
[4] Redell MS, et al. Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood. 2011;117(21):5701-5709. DOI:10.1182/blood-2010-04-280123
C188-9 Preparation Products And Raw materials
Raw materials
Preparation Products
C188-9 Suppliers
- Tel
- 17702719238 18971495150;
- sales@sun-shinechem.com
- Country
- China
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- China
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- 18149758185
- sales-cpd@caerulumpharma.com
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- China
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- 400-164-7117 13681763483
- Fax
- +86-21-61629029
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- China
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- 39966
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- 025-58849295 18951903616;
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- 025-68650336
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- China
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- 021-52996696，15000506266 15000506266
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- +86-21-52996696
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- China
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- 021-61350663 13052117465
- Fax
- 021-61350662
- sales@zehanbiopharma.com
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- China
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- 17764003753
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- 17764003753
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- 13669031409
- 2326587775@qq.com
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- China
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- 18122150900
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- QQ:2869377561
- sculk28@163.com
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