C188-9
- Product Name
- C188-9
- CAS No.
- 432001-19-9
- Chemical Name
- C188-9
- Synonyms
- TTI-101;C188-9;F0808-0084;STAT3 inhibitor TTI-101;C 188-9;C-188-9;C-1889;C1889;C 1889;C-1889;F0808-0084;C188-9; C 188-9; C-188-9; C-1889; C1889; C 1889; C-1889; F0808-0084;N-(1',2-Dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide;N-(1',2-Dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide;N-(1',2-dihydroxy-1.2'-binaphthhalen-4'-yl)-4-methoxybenzene-sulphonamide;Benzenesulfonamide, N-(1',2-dihydroxy[1,2'-binaphthalen]-4'-yl)-4-methoxy-
- CBNumber
- CB23959200
- Molecular Formula
- C27H21NO5S
- Formula Weight
- 471.52
- MOL File
- 432001-19-9.mol
C188-9 Property
- Boiling point:
- 680.9±65.0 °C(Predicted)
- Density
- 1.416±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml
- form
- A crystalline solid
- pka
- 8.14±0.50(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0044737
- Product name
- C188-9
- Purity
- 99.50%
- Packaging
- 5mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CS-0044737
- Product name
- C188-9
- Purity
- 99.50%
- Packaging
- 10mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- CS-0044737
- Product name
- C188-9
- Purity
- 99.50%
- Packaging
- 25mg
- Price
- $290
- Updated
- 2021/12/16
- Product number
- CS-0044737
- Product name
- C188-9
- Purity
- 99.50%
- Packaging
- 50mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- CS-0044737
- Product name
- C188-9
- Purity
- 99.50%
- Packaging
- 100mg
- Price
- $720
- Updated
- 2021/12/16
C188-9 Chemical Properties,Usage,Production
Biological Activity
C188-9 (TTI 101) is a potent STAT3 inhibitor, binds STAT3 with high affinity, Kd=4.7±0.4 nM. It is well tolerated in mice, has good oral bioavailability, and is mainly enriched in tumor tissues.
in vitro
C188-9 is a small molecule inhibitor of STAT3, targeting the phosphotyrosine peptide binding site in the SH2 region of STAT3 with a Ki value of 136 nM. It does not inhibit upstream Jak or Src kinases.
in vivo
C188-9 inhibited tumor growth in mice bearing UM-SCC-17B xenografts after administration of C188-9. C188-9 was well tolerated in mice, had good oral bioavailability, and was concentrated in tumor tissue after administration.
target
| Target | Value |
| STAT3 (Cell-free) | 4.7 nM(Kd) |
C188-9 Preparation Products And Raw materials
Raw materials
Preparation Products
C188-9 Suppliers
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6393
- Advantage
- 58
- Tel
- +1-833-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 57511
- Advantage
- 58
- Tel
- +1-781-999-5354
- support@targetmol.com
- Country
- United States
- ProdList
- 19973
- Advantage
- 58