C188-9

Product Name: C188-9
CAS No.: 432001-19-9
Chemical Name: C188-9
Synonyms: TTI-101;C188-9;F0808-0084;C188-9, 10 mM in DMSO;STAT3 inhibitor TTI-101;STAT3 Inhibitor XIII, C188-9;C 188-9;C-188-9;C-1889;C1889;C 1889;C-1889;F0808-0084;C188-9; C 188-9; C-188-9; C-1889; C1889; C 1889; C-1889; F0808-0084;N-(1',2-Dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide;N-(1',2-dihydroxy-1.2'-binaphthhalen-4'-yl)-4-methoxybenzene-sulphonamide
CBNumber: CB23959200
Molecular Formula: C27H21NO5S
Formula Weight: 471.52
MOL File: 432001-19-9.mol

More

Less

C188-9 Property

Boiling point:: 680.9±65.0 °C(Predicted)
Density: 1.416±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml
form: A crystalline solid
pka: 8.14±0.50(Predicted)
color: Off-white to pink

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 573128
Product name: STAT3 Inhibitor XIII, C188-9
Purity: The Stat3 Inhibitor XIII, C188-9 controls the biological activity of Stat3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Packaging: 10 mg
Price: $177
Updated: 2025/07/31

ChemScene

Product number: CS-0044737
Product name: C188-9
Purity: 99.50%
Packaging: 5mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-0044737
Product name: C188-9
Purity: 99.50%
Packaging: 10mg
Price: $140
Updated: 2021/12/16

ChemScene

Product number: CS-0044737
Product name: C188-9
Purity: 99.50%
Packaging: 25mg
Price: $290
Updated: 2021/12/16

ChemScene

Product number: CS-0044737
Product name: C188-9
Purity: 99.50%
Packaging: 50mg
Price: $460
Updated: 2021/12/16

More

Less

C188-9 Chemical Properties,Usage,Production

Uses

C188-9 (TTI-101) is a STAT3 inhibitor, with a Kd of 4.7 nM. C188-9 inhibits G-CSF-induced STAT3 activation and STAT3-dependent gene expression. C188-9 induces apoptosis in AML cell lines and primary samples and inhibits colony formation by primary AML blasts[1][2][3][4].

Biological Activity

C188-9 (TTI 101) is a potent STAT3 inhibitor, binds STAT3 with high affinity, Kd=4.7±0.4 nM. It is well tolerated in mice, has good oral bioavailability, and is mainly enriched in tumor tissues.

in vitro

C188-9 is a small molecule inhibitor of STAT3, targeting the phosphotyrosine peptide binding site in the SH2 region of STAT3 with a Ki value of 136 nM. It does not inhibit upstream Jak or Src kinases.

in vivo

C188-9 inhibited tumor growth in mice bearing UM-SCC-17B xenografts after administration of C188-9. C188-9 was well tolerated in mice, had good oral bioavailability, and was concentrated in tumor tissue after administration.

target

Target	Value
STAT3 (Cell-free)	4.7 nM(Kd)

IC 50

STAT3: 4.7 nM (Kd)

References

[1] Silva KA, et al. Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia. J Biol Chem. 2015 Apr 24;290(17):11177-87. DOI:10.1074/jbc.M115.641514
[2] Redell MS, et al. Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood. 2011 May 26;117(21):5701-9. DOI:10.1182/blood-2010-04-280123
[3] Bharadwaj U, et al. Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget. 2016 May 3;7(18):26307-30. DOI:10.18632/oncotarget.8368
[4] Redell MS, et al. Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood. 2011;117(21):5701-5709. DOI:10.1182/blood-2010-04-280123

C188-9 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

C188-9 Suppliers

China 90 India 1 United States 6 Global 97

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354;
Email: support@targetmol.com
Country: United States
ProdList: 39035
Advantage: 58

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

432001-19-9, C188-9Related Search:

C188-9

C 188-9;C-188-9;C-1889;C1889;C 1889;C-1889;F0808-0084

N-(1',2-dihydroxy-1.2'-binaphthhalen-4'-yl)-4-methoxybenzene-sulphonamide

C188-9; C 188-9; C-188-9; C-1889; C1889; C 1889; C-1889; F0808-0084

F0808-0084

TTI-101

Benzenesulfonamide, N-(1',2-dihydroxy[1,2'-binaphthalen]-4'-yl)-4-methoxy-

N-(1',2-Dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide

C1889,Apoptosis,STAT,Inhibitor,C188 9,C-188-9,C188-9,TTI101,TTI 101,inhibit

STAT3 inhibitor TTI-101

C188-9, 10 mM in DMSO

STAT3 Inhibitor XIII, C188-9

432001-19-9