ChemicalBook > CAS DataBase List > MCA-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2

MCA-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2

Product Name: MCA-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2
CAS No.: 140430-53-1
Chemical Name: MCA-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2
Synonyms: MCA-PLGL-DPA-AR-NH2;MMP-2/MMP-7 SUBSTRATE;MCA-PLGL-DAP(DNP)-AR-NH2;390 MMP FRET SUBSTRATE I;MCA-PLGL-DAP(DNP)-ALA-ARG-NH2;FLUORESCENT PEPTIDE SUBSTRATE I;390 MMP FRET Substrate 1 - 1 mg;MMP-2/MMP-7 SUBSTRATE, FLUOROGENIC;MCA-PRO-LEU-GLY-LEU-DPA-ALA-ARG-NH2;MCA-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2
CBNumber: CB2397597
Molecular Formula: C49H68N14O15
Formula Weight: 1093.15
MOL File: 140430-53-1.mol

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MCA-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2 Property

Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: −20°C
solubility: 20% acetic acid: 1mg/mL
form: Solid
pka: 12.99±0.46(Predicted)
color: Light yellow to yellow
Appearance: Yellow Powder
InChIKey: RQASLOJQHHELIQ-QJSKOQLASA-N

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 03-32-5032
Product name: MMP-2/MMP-7 Substrate, Fluorogenic
Purity: Extremely sensitive fluorogenic substrate for matrix metalloproteinases (MMPs).
Packaging: 1MG
Price: $227.05
Updated: 2025/07/31

Cayman Chemical

Product number: 24149
Product name: 7-Methoxycoumarin-4-acetyl-P-L-G-L-β-(2,4-dinitrophenylamino)A-R amide
Purity: ≥95%
Packaging: 500μg
Price: $89
Updated: 2021/12/16

Cayman Chemical

Product number: 24149
Product name: 7-Methoxycoumarin-4-acetyl-P-L-G-L-β-(2,4-dinitrophenylamino)A-R amide
Purity: ≥95%
Packaging: 1mg
Price: $169
Updated: 2021/12/16

Chem-Impex

Product number: 33015
Product name: Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2trifluoroacetatesalt
Packaging: 1MG
Price: $223.64
Updated: 2021/12/16

ApexBio Technology

Product number: A1500
Product name: 7-Methoxycoumarin-4-acetyl-P-L-G-L-β-(2,4-dinitrophenylamino)A-Ramide
Packaging: 10mg
Price: $500
Updated: 2021/12/16

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MCA-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2 Chemical Properties,Usage,Production

Description

7-Methoxycoumarin-4-acetyl-P-L-G-L-β-(2,4-dinitrophenylamino)A-R amide is a fluorogenic substrate for matrix metalloproteinases (MMPs). It is ceaved by an MMP to release the fluorescent moiety 7-methoxycoumarin-4-acetyl (Mca), which can be used to quantify MMP activity.

Uses

MOCAc-PLGL(Dpa)AR is a positively charged fluorescent substrate for matrix metalloproteinase-2 (MMP-2), MMP-7 and MMP-9. MOCAc-PLGL(Dpa)AR is a substrate of matrilysin, can be cleaved at the peptide bond between the glycine and leucine residues[1][2].

Biological Activity

Cell permeable: no', 'Primary Target
Fluorogenic substrate for matrix metalloproteinases (MMPs)', 'Product does not compete with ATP.', 'Reversible: no', 'kcat/Km = 1.7 x 105 M-1sec-1 for MMP-7 and 6.3 x 105 M-¹ sec-¹ for MMP-2

References

[1] Oneda H, et al. Substrate-dependent activation of thermolysin by salt. Biosci Biotechnol Biochem. 2004 Aug;68(8):1811-3. DOI:10.1271/bbb.68.1811
[2] Oneda H, et al. Inhibitory effects of green tea catechins on the activity of human matrix metalloproteinase 7 (matrilysin). J Biochem. 2003 May;133(5):571-6. DOI:10.1093/jb/mvg073

Sequene

Mca-PLGL-Dap(Dnp)-AR-NH2

MCA-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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MCA-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2 Suppliers

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140430-53-1, MCA-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2Related Search:

2-Ethyl-5-nitrobenzenamine ,98% BIS(2-AMINOPROPYL)AMINE 7-Methoxycoumarin N,N'-Bis(2-aminoethyl)-1,3-propanediamine N1-(2,4-DINITRO-PHENYL)-ETHANE-1,2-DIAMINE 7-Methoxycoumarin 1-NITRO-2-PROPYLBENZENE 3-(2-HYDROXYPHENYL)PROPIONAMIDE 3-(4-NITROPHENYL)PROPAN-1-AMINE 3-(2-NITRO-PHENYL)-PROPIONALDEHYDE CHEMBRDG-BB 7932577 MCA-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2 2-(2-NITROPHENYL)ETHANAMINE N-(4-NITRO-BENZYL)-FORMAMIDE N-(4-AMINO-BENZYL)-ACETAMIDE 4-(1-AMINO-ETHYL)-PHENYLAMINE MOCAC-PRO-LEU-GLY 3-[(4-AMINOPHENYL)AMINO]-PROPANAMIDE

MOCAC-PRO-LEU-GLY-LEU-N3-[2,4-DINITROPHENYL]-L-2,3-DIAMINOPROPIONYL-ALA-ARG-NH2

MMP-2/MMP-7 SUBSTRATE

MMP-2/MMP-7 SUBSTRATE, FLUOROGENIC

MCA-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2

MCA-PRO-LEU-GLY-LEU-DPA-ALA-ARG-NH2

MCA-PLGL-DAP(DNP)-ALA-ARG-NH2

MCA-PLGL-DAP(DNP)-AR-NH2

MCA-PLGL-DPA-AR-NH2

FLUORESCENT PEPTIDE SUBSTRATE I

7-methoxycoumarin-4-acetyl-pro-leu-*gly-leu-B-(2,

7-METHOXYCOUMARIN-4-ACETYL-PRO-LEU-*GLY- LEU-B-(2,4-

7-methoxycoumarin-4-acetyl-pro-leu-gly-leu-β-(2,4-dinitrophenylamino)ala-ala-arg amide

7-Methoxycoumarin-4-acetyl-P-L-G-L-β-(2,4-dinitrophenylamino)A-R amide

390 MMP FRET SUBSTRATE I

(7-METHOXYCOUMARIN-4-YL)ACETYL-L-PROLYL-L-LEUCYLGLYCYL-L-LEUCYL-[N-BETA-(2,4-DINITROPHENYL)-L-2,3-DIAMINOPROPIONYL]-L-ALANYL-L-ARGININE AMIDE

7-METHOXYCOUMARIN-4-ACETYL-PRO-LEU-GLY-LEU-BETA-(2,4-DINITROPHENYLAMINO)ALA-ALA-ARG AMIDE

7-METHOXYCOUMARIN-4-ACETYL-PRO-LEU-GLY-LEU-DNP-(2,3-DIAMINOPROPIONYL)-ALA-ARG, AMIDE

MOCAC-PRO-LEU-GLY-LEU-[3-DNP-2,3-DAP]-ALA-ARG, AMIDE

MOCAC-PRO-LEU-GLY-LEU-A2PR(DNP)-ALA-ARG-NH2

7-Methoxycoumarin-4-acetyl-Pro-Leu-Gly-Leu-β-(2,4-dinitrophenylamino)Ala-Arg amide

MCA-PRO-LEU-GLY-LEU-DAP-ALA-ARG-NH2: MCA-PLGL-DAP-AR-NH2

Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (Mca7-MethoxycouMarin-4-acetyl)

7-Methoxycoumarin-4-acetyl-P-L-G-L-β-(2,4-dinitrophenylamino)A-R amide

31:PN:WO2005051299 SEQID:215 unclaimed sequence

L-Argininamide, 1-[(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-prolyl-L-leucylglycyl-L-leucyl-3-[(2,4-dinitrophenyl)amino]-L-alanyl-L-alanyl-

390 MMP FRET Substrate 1 - 1 mg

Mca-Pro-Leu-Gly-Leu-Dap (Dnp)-Ala-Arg-NH2 trifluoroacetate salt

140430-53-1

C49H68N14O15

BioChemical

Biochemicals and Reagents

Substrates by Enzyme

Matrix metalloproteinase

Enzyme Substrates

Enzymes, Inhibitors, and Substrates

peptides

peptide