PAXILLINE
- Product Name
- PAXILLINE
- CAS No.
- 57186-25-1
- Chemical Name
- PAXILLINE
- Synonyms
- PAXILINE;mycillin;PAXILLINE;Paxicillin;Paxilline solution;Paxilline in Methanol;PAXILLINE, PENICILLIUM PAXILLI;paxilline from penicillium paxilli;4b-beta,6a-alpha,12b-beta,12c-alpha,14a-beta)-2-alph;14,14a-decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-(
- CBNumber
- CB2402640
- Molecular Formula
- C27H33NO4
- Formula Weight
- 435.56
- MOL File
- 57186-25-1.mol
PAXILLINE Property
- Flash point:
- 2℃
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO, acetone or chloroform.
- form
- powder
- color
- faint yellow
Safety
- Hazard Codes
- T,Xn,F
- Risk Statements
- 23/24/25-36/37/38-41-36-20/21/22-11
- Safety Statements
- 26-36/37/39-45-36/37-16
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- DJ2830000
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29419090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P2928
- Product name
- Paxilline
- Purity
- powder, ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $414
- Updated
- 2024/03/01
- Product number
- J61341
- Product name
- Paxilline, 97+%
- Packaging
- 5mg
- Price
- $216.65
- Updated
- 2024/03/01
- Product number
- J61341
- Product name
- Paxilline, 97+%
- Packaging
- 25mg
- Price
- $639
- Updated
- 2021/12/16
- Product number
- 11345
- Product name
- Paxilline
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $45
- Updated
- 2024/03/01
- Product number
- 11345
- Product name
- Paxilline
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $121
- Updated
- 2024/03/01
PAXILLINE Chemical Properties,Usage,Production
Description
A complex alkaloid, paxilline occurs in the mycelium of the mold Penicillium paxilli. The structure has been confirmed by X-ray crystallography. The crystals are orthorhombic with space group P2 12 121 and a = 31.009, b = 11.522 and c = 7.70 A.
Description
Paxilline is an indole diterpene from fungi which potently and reversibly inhibits large conductance Ca2+-
Chemical Properties
Powder
Uses
Potent blocker of high-conductance calcium-activated potassium (BKCa) channels
Uses
Paxilline is a tremorgenic mycotoxin isolated from species of Penicillium, Acremonium and Emericella. Paxilline selectively blocks high-conductance Ca2+-activated potassium channels and inhibits binding to the cerebellar inositol 1,4,5-triphosphate (InsP(3)) receptor.
Definition
ChEBI: Paxilline is an indole diterpene alkaloid with formula C27H33NO4 isolated from Penicillium paxilli. It is a potent inhibitor of large conductance Ca2(+)- and voltage-activated K(+) (BK)-type channels. It has a role as a mycotoxin, a Penicillium metabolite, an anticonvulsant, an Aspergillus metabolite, a potassium channel blocker, a genotoxin, a geroprotector and an EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor. It is an organic heterohexacyclic compound, a tertiary alcohol, a terpenoid indole alkaloid, an enone and a diterpene alkaloid.
Biological Activity
Potent blocker of high-conductance Ca 2+ -activated K + (BK Ca ) channels. Binds to the α -subunit of BK Ca (K i = 1.9 nM for block of currents in α -subunit-expressing oocytes) and enhances binding of charybdotoxin to BK Ca channels in vascular smooth muscle. Also inhibits sarco/endoplasmic reticulum Ca 2+ -ATPase (IC 50 = 5-50 μ M).
Enzyme inhibitor
This BKCa/KCa1.1) channel blocker (FW = 435.56 g/mol; CAS 57186-25-1; Solubility: 100 mM in DMSO), also named (2R,4bS,6aS,12bS,12cR,14aS)- 5,6,6a,7,12,12b,12c,13,14,14a-decahydro-4b-hydroxy-2-(1-hydroxy-1- methylethyl)-12b,12c-dimethyl-2H-pyrano[2'',3'': 5',6']benz[1',2':6,7]indeno [1,2-b]indol-3(4bH)-one, binds to the α-subunit of BKCa, exhibiting a Ki value of 1.9 nM in blocking currents in α-subunit-expressing oocytes and enhancing binding of to BKCa channels in vascular smooth muscle. (See Charybdotoxin) Paxilline also inhibits sarco/endoplasmic reticulum Ca2+-ATPase, IC50 = 5 - 50 μM.
storage
-20°C (desiccate)
References
Springer et ai., Tetrahedron Lett., 2531 (1975)
PAXILLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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