ChemicalBook > CAS DataBase List > (2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER

(2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER

Product Name: (2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER
CAS No.: 22446-37-3
Chemical Name: (2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER
Synonyms: Einecs 245-004-5;Methyl o-hydroxyphenylacetate;METHYL 2-HYDROXYPHENYL ACETATE;Methyl 2-hydroxybenzeneacetate;Methyl 2-(2-hydroxyphenyl)acetate;vMethyl 2-(2-hydroxyphenyl)acetate;2-Hydroxybenzeneacetic acid methyl ester;(2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER;Benzeneacetic acid, 2-hydroxy-, methyl ester;Acetic acid, (o-hydroxyphenyl)-, methyl ester
CBNumber: CB2403197
Molecular Formula: C9H10O3
Formula Weight: 166.17
MOL File: 22446-37-3.mol

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(2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER Property

Melting point:: 122-124℃
Boiling point:: 115-120℃ (0.3 Torr)
Density: 1.181±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform, Methanol (Slightly)
form: Solid
pka: 9.55±0.30(Predicted)
color: Off-White to Light Brown
InChI: InChI=1S/C9H10O3/c1-12-9(11)6-7-4-2-3-5-8(7)10/h2-5,10H,6H2,1H3
InChIKey: BVBSGGBDFJUSIH-UHFFFAOYSA-N
SMILES: C1(CC(OC)=O)=CC=CC=C1O

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Safety

HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: M312795
Product name: Methyl2-(2-Hydroxyphenyl)acetate
Packaging: 5g
Price: $170
Updated: 2021/12/16

AK Scientific

Product number: E025
Product name: Methyl2-(2-hydroxyphenyl)acetate
Packaging: 1g
Price: $20
Updated: 2021/12/16

AK Scientific

Product number: E025
Product name: Methyl2-(2-hydroxyphenyl)acetate
Packaging: 5g
Price: $60
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2629-1-0Y
Product name: Methyl (2-hydroxyphenyl)acetate
Packaging: 1g
Price: $156
Updated: 2021/12/16

Oakwood

Product number: 234007
Product name: Methyl2-(2-hydroxyphenyl)acetate
Purity: 98%
Packaging: 5g
Price: $180
Updated: 2021/12/16

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(2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER Chemical Properties,Usage,Production

Chemical Properties

It is white powdery crystal, m.p. 70～72℃, insoluble in water, soluble in benzene, toluene, acetone.

Uses

Methyl 2-(2-Hydroxyphenyl)acetate is used as a reactant in the preparation of caffeic acid phenylethyl esters as ?antiproliferative agents.

Definition

ChEBI: Methyl (2-hydroxyphenyl)acetate is a member of phenols.

Synthesis Reference(s)

Synthetic Communications, 24, p. 2743, 1994 DOI: 10.1080/00397919408010590

Synthesis

67-56-1

614-75-5

22446-37-3

Preparative Example 1A: Synthesis of methyl 2-hydroxyphenylacetate: o-hydroxyphenylacetic acid (400 g, 2.63 mmol) was dissolved in methanol (3.0 L), and the esterification reaction was carried out by passing hydrogen chloride gas into the solution. The reaction was stirred continuously for 2 hours at room temperature. Upon completion of the reaction, the reaction mixture was concentrated and dried under vacuum to afford the title compound 1A (415 g, 95% yield), the product was initially a yellow oil and solidified to a solid after standing overnight. The structure of the product was confirmed by 1H NMR (CDCl3, 400 MHz): δ 7.20-7.16 (m, 1H), 7.11-7.09 (m, 1H), 6.93-6.86 (m, 2H), 4.48 (br s, 1H), 3.74 (s, 2H), 3.69 (s, 3H).

References

[1] Organic and Biomolecular Chemistry, 2013, vol. 11, # 31, p. 5147 - 5155
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 21, p. 8948 - 8952
[3] Organic Letters, 2008, vol. 10, # 18, p. 3969 - 3972
[4] Patent: WO2015/102990, 2015, A1. Location in patent: Paragraph 0193-0195
[5] Journal of Organic Chemistry, 1994, vol. 59, # 1, p. 203 - 213

(2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

2-Hydroxyphenylacetic acid Sodium bicarbonate Thionyl chloride

Preparation Products

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View Lastest Price from (2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: (2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER 22446-37-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 97%
Supply Ability: 2000
Release date: 2025-09-25

Career Henan Chemical Co

Product: (2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER 22446-37-3
Price: US $8.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-25

22446-37-3, (2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTERRelated Search:

Propantheline bromide Vinfosiltine Valrubicin METHANTHELINE BROMIDE METHYL 9H-XANTHENE-9-CARBOXYLATE Vincristine sulfate Ethyl 9H-xanthene-9-carboxylate ETHYL 3-HYDROXY-4,6-DIMETHOXY-2-OXOINDOLINE-3-CARBOXYLATE (2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER Methyl cyclopentylphenylglycolate 3,4-DIHYDROXYPHENYLACETIC ACID METHYL ESTER METHYL A YCLOPENTYLMANDELATE Methyl 3,5-dihydroxyphenylacetate HYDROXY-PHENYL-ACETIC ACID METHYL ESTER Methyl 4-hydroxyphenylacetate METHYL 2-AMINO-2-(4-HYDROXYPHENYL)ACETATE Methyl cyclohexylphenylglycolate HYDROXY-PHENYL-ACETIC ACID METHYL ESTER

Benzeneacetic acid, 2-hydroxy-, methyl ester

Methyl o-hydroxyphenylacetate

Methyl 2-(2-hydroxyphenyl)acetate

Methyl 2-hydroxybenzeneacetate

METHYL 2-HYDROXYPHENYL ACETATE

(2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER

Acetic acid, (o-hydroxyphenyl)-, methyl ester

2-Hydroxybenzeneacetic acid methyl ester

Einecs 245-004-5

vMethyl 2-(2-hydroxyphenyl)acetate

22446-37-3

pharmacetical