(2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER
- Product Name
- (2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER
- CAS No.
- 22446-37-3
- Chemical Name
- (2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER
- Synonyms
- Einecs 245-004-5;Methyl o-hydroxyphenylacetate;METHYL 2-HYDROXYPHENYL ACETATE;Methyl 2-hydroxybenzeneacetate;Methyl 2-(2-hydroxyphenyl)acetate;vMethyl 2-(2-hydroxyphenyl)acetate;2-Hydroxybenzeneacetic acid methyl ester;(2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER;Benzeneacetic acid, 2-hydroxy-, methyl ester;Acetic acid, (o-hydroxyphenyl)-, methyl ester
- CBNumber
- CB2403197
- Molecular Formula
- C9H10O3
- Formula Weight
- 166.17
- MOL File
- 22446-37-3.mol
(2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER Property
- Melting point:
- 122-124℃
- Boiling point:
- 115-120℃ (0.3 Torr)
- Density
- 1.181±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform, Methanol (Slightly)
- form
- Solid
- pka
- 9.55±0.30(Predicted)
- color
- Off-White to Light Brown
- InChI
- InChI=1S/C9H10O3/c1-12-9(11)6-7-4-2-3-5-8(7)10/h2-5,10H,6H2,1H3
- InChIKey
- BVBSGGBDFJUSIH-UHFFFAOYSA-N
- SMILES
- C1(CC(OC)=O)=CC=CC=C1O
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- M312795
- Product name
- Methyl2-(2-Hydroxyphenyl)acetate
- Packaging
- 5g
- Price
- $170
- Updated
- 2021/12/16
- Product number
- E025
- Product name
- Methyl2-(2-hydroxyphenyl)acetate
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- E025
- Product name
- Methyl2-(2-hydroxyphenyl)acetate
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 2629-1-0Y
- Product name
- Methyl (2-hydroxyphenyl)acetate
- Packaging
- 1g
- Price
- $156
- Updated
- 2021/12/16
- Product number
- 234007
- Product name
- Methyl2-(2-hydroxyphenyl)acetate
- Purity
- 98%
- Packaging
- 5g
- Price
- $180
- Updated
- 2021/12/16
(2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER Chemical Properties,Usage,Production
Chemical Properties
It is white powdery crystal, m.p. 70～72℃, insoluble in water, soluble in benzene, toluene, acetone.
Uses
Methyl 2-(2-Hydroxyphenyl)acetate is used as a reactant in the preparation of caffeic acid phenylethyl esters as ?antiproliferative agents.
Definition
ChEBI: Methyl (2-hydroxyphenyl)acetate is a member of phenols.
Synthesis Reference(s)
Synthetic Communications, 24, p. 2743, 1994 DOI: 10.1080/00397919408010590
Synthesis
67-56-1
614-75-5
22446-37-3
Preparative Example 1A: Synthesis of methyl 2-hydroxyphenylacetate: o-hydroxyphenylacetic acid (400 g, 2.63 mmol) was dissolved in methanol (3.0 L), and the esterification reaction was carried out by passing hydrogen chloride gas into the solution. The reaction was stirred continuously for 2 hours at room temperature. Upon completion of the reaction, the reaction mixture was concentrated and dried under vacuum to afford the title compound 1A (415 g, 95% yield), the product was initially a yellow oil and solidified to a solid after standing overnight. The structure of the product was confirmed by 1H NMR (CDCl3, 400 MHz): δ 7.20-7.16 (m, 1H), 7.11-7.09 (m, 1H), 6.93-6.86 (m, 2H), 4.48 (br s, 1H), 3.74 (s, 2H), 3.69 (s, 3H).
References
[1] Organic and Biomolecular Chemistry, 2013, vol. 11, # 31, p. 5147 - 5155
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 21, p. 8948 - 8952
[3] Organic Letters, 2008, vol. 10, # 18, p. 3969 - 3972
[4] Patent: WO2015/102990, 2015, A1. Location in patent: Paragraph 0193-0195
[5] Journal of Organic Chemistry, 1994, vol. 59, # 1, p. 203 - 213
(2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
(2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER Suppliers
- Tel
- --
- Fax
- --
- sales@chemos-group.com
- Country
- Germany
- ProdList
- 6350
- Advantage
- 71
View Lastest Price from (2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER manufacturers
- Product
- (2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER 22446-37-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 97%
- Supply Ability
- 2000
- Release date
- 2025-09-25
- Product
- (2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER 22446-37-3
- Price
- US $8.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-25