ChemicalBook > CAS DataBase List > (-)-MK-801 MALEATE

(-)-MK-801 MALEATE

Product Name
(-)-MK-801 MALEATE
CAS No.
77086-22-7
Chemical Name
(-)-MK-801 MALEATE
Synonyms
mk801;(+)MK801;(+)MK108;MK 801 ;MK801;(-)-MK-801 MALEATE;Dizocipine maleate;(+)Mk801/MK801/MK-801;(+)-MK-801·Maleic acid;MK-801(Dizocilpine)Maleate;(+/-)-mk-801 hydrogen maleate
CBNumber
CB2407483
Molecular Formula
C20H19NO4
Formula Weight
337.38
MOL File
77086-22-7.mol
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(-)-MK-801 MALEATE Property

Melting point:
208.5-210°
alpha 
D20 +114° (c = 0.0128 g/2 ml ethanol)
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO: >20 mg/mL
form 
solid
color 
white
optical activity
[α]25/D +117°, c = 1 in methanol(lit.)
InChIKey
QLTXKCWMEZIHBJ-FWHYOZOBSA-N
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
HP1093575
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

H361Suspected of damaging fertility or the unborn child

H370Causes damage to organs

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P307+P311IF exposed: call a POISON CENTER or doctor/physician.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M107
Product name
(+)-MK-801 hydrogen maleate
Purity
powder
Packaging
5mg
Price
$119
Updated
2024/03/01
Sigma-Aldrich
Product number
475878
Product name
(+)-MK 801 Maleate
Packaging
10mg
Price
$152
Updated
2022/05/15
Alfa Aesar
Product number
J63917
Product name
Dizocilpine maleate, 99+%
Packaging
10mg
Price
$120
Updated
2024/03/01
Alfa Aesar
Product number
J63917
Product name
Dizocilpine maleate, 99+%
Packaging
50mg
Price
$369
Updated
2024/03/01
Cayman Chemical
Product number
10009019
Product name
(+)-MK-801 (hydrogen maleate)
Purity
≥99%
Packaging
10mg
Price
$72
Updated
2024/03/01
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(-)-MK-801 MALEATE Chemical Properties,Usage,Production

Uses

Dizocilpine maleate is used to interact at the NMDA-associated ion channel, preventing Ca2+ flux and blocking NMDA-induced depolarizations. (+)-MK 801 demonstrates potent neuroprotective effects against excitotoxic insult, showing substantial protection against neuron loss produced by NMDA and quinolinic acid introduction.

Uses

(-)-MK-801 MALEATE is probe for NMDA receptors

Uses

(-)-MK-801 MALEATE acts as an NMDA receptor antagonist. It is selective and potent, but noncompetitive, used in various ischemia treatments.

Definition

ChEBI: Dizocilpine maleate is a maleate salt obtained by reaction of dizocilpine with one equivalent of maleic acid. It has a role as an anaesthetic, an anticonvulsant, a neuroprotective agent, a nicotinic antagonist and a NMDA receptor antagonist. It is a maleate salt and a tetracyclic antidepressant. It contains a dizocilpine(1+).

General Description

A highly potent, selective and non-competitive NMDA receptor antagonist that acts by binding to a site located within the NMDA associated ion channel, preventing Ca2+ flux. An effective anti-ischemic agent in several animal models. Has been used to develop an in vivo model of NMDA receptor-dependent apoptotic neurodegenerative disease in developing rat brains. Has also been used to develop an in vitro model of NMDA receptor-specific Ca2+ entry induced seizures.

Biological Activity

(-)-MK-801 MALEATE is a potent, selective and non-competitive NMDA receptor antagonist. Acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca 2+ flux. An effective anti-ischemic agent in several animal models. Also available as part of the Mixed NMDA Receptor Tocriset™ .

Biochem/physiol Actions

Primary TargetNMDA receptor

storage

Room temperature

References

[1] wong eh, kemp ja, priestley t, knight ar, woodruff gn, iversen ll . the anticonvulsant mk-801 is a potent n-methyl-d-aspartate antagonist. proc natl acad sci u s a. 1986 sep;83(18):7104-8.

(-)-MK-801 MALEATE Preparation Products And Raw materials

Raw materials

Preparation Products

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(-)-MK-801 MALEATE Suppliers

Canada 2 China 93 Europe 2 Germany 6 India 8 Italy 1 Japan 4 Spain 1 Switzerland 4 United Kingdom 7 United States 22 Global 150
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
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69
ZHIWE CHEMTECH CO LTD
Tel
021-20221225 13917446399
Fax
QQ:115820162
Email
sales@zhiwe.net
Country
China
ProdList
608
Advantage
61
Ascent Scientific
Tel
4401179829988
Fax
4402030 700 369
Email
customerservice@ascentscientific.co.uk
Country
United Kingdom
ProdList
279
Advantage
60
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4552
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62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
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58
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19915
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
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View Lastest Price from (-)-MK-801 MALEATE manufacturers

Career Henan Chemical Co
Product
(-)-MK-801 MALEATE 77086-22-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%HPLC
Supply Ability
100KG
Release date
2020-02-05

77086-22-7, (-)-MK-801 MALEATERelated Search:

(-)-MK 801 MALEATE, >99% (-)-MK-801 MALEATE (+)-MK 801 MALEATE,(-)-MK 801 MALEATE

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  • d)cyclohepten-5,10-imine,10,11-dihydro-5-methyl-5h-dibenzo((5s)-5h-dibenzo((z)-2-b
  • mk801
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  • (+)-MK-801 HYDROGEN MALEATE (DIZOCILPINE MALEATE)
  • (5S,10R)-(+)-5-Methyl-10,11-dihydro-(5H)-dibenzo[a.d]cycloheptene-5,10-iminemaleate
  • Dizocilpine hydrogen maleate, (5R,10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate
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  • [5R,10S,(-)]-10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine
  • [5R,10S,(-)]-10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5β,10β-imine
  • (+)-MK-801·Maleic acid
  • Dizocipine maleate
  • DIZOCILPINE MALEATE;DIZOCILPINE HYDROGEN MALEATE;(+)-MK 801;MK 801;MK801
  • (+)MK801
  • (+)-MK 801 Maleate - CAS 77086-22-7 - Calbiochem
  • MK 801 ;MK801
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  • (5S)-10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine (Z)-2-butenedioate
  • 5-Methyl-10,11-dihydro-5H-5,10-epiMinodibenzo[a,d][7]annulene (2Z)-but-2-enedioate
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  • Dizocilpine Maleate [(+)-MK 801 maleate
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  • (5S,10R)-5-Methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene maleate
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  • BioChemical
  • Ion Channels
  • Ionotropic Glutamate Receptor Modulators
  • Ligand-Gated Ion Channels
  • Glutamate
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  • APIs