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MSOP

Product Name
MSOP
CAS No.
66515-29-5
Chemical Name
MSOP
Synonyms
MSOP;2-Methyl-O- phosphonoserine;Serine, 2-methyl-O-phosphono-;(RS)-α-Methylserine-O-phosphate;(R,S)-a-Methylserine-O-phosphate;(RS)-ALPHA-METHYLSERINE-O-PHOSPHATE;MSOP, group III metabotropic glutamate receptor antagonist
CBNumber
CB2407711
Molecular Formula
C4H10NO6P
Formula Weight
199.1
MOL File
66515-29-5.mol
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MSOP Property

Boiling point:
454.0±55.0 °C(Predicted)
Density 
1.681±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
H2O: soluble3mg/mL, clear (warmed)
form 
powder
pka
1.66±0.10(Predicted)
color 
white to beige
Water Solubility 
Soluble to 100 mM in water
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Tocris
Product number
0803
Product name
MSOP
Packaging
5
Price
$115
Updated
2021/12/16
Tocris
Product number
0803
Product name
MSOP
Packaging
25
Price
$432
Updated
2021/12/16
Usbiological
Product number
456675
Product name
MSOP
Packaging
10mg
Price
$439
Updated
2021/12/16
TRC
Product number
M755425
Product name
MSOP
Packaging
50mg
Price
$450
Updated
2021/12/16
Usbiological
Product number
255915
Product name
MSOP
Packaging
10mg
Price
$466
Updated
2021/12/16
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MSOP Chemical Properties,Usage,Production

Uses

MSOP is a selective antagonist of group III mGlu receptors.

Biological Activity

MSOP is a selective group III metabotropic glutamate receptor antagonist. Displays an apparent KD of 51 μM for the L-AP4-sensitive presynaptic mGluR on primary afferent terminals in spinal cord compared to > 700 μM for the (1S,3S)-ACPD-sensitive presynaptic mGlu in the same system. Has no activity on postsynaptic mGlu receptors or on ionotropic glutamate receptors on neonatal rat motoneurons.

in vivo

It is found that TBOA-induced antinociceptive effects are significantly blocked by intrathecal co-administration of MSOP (second phase of formalin model: F3,16=30.96, P<0.001; CFA model: F3,16=30.77, P<0.001). As expected, intrathecal TBOA (10 μg) reduces the number of formalin-induced flinches and shakes by 47% of the value in the saline-treated group in the second phase (P<0.001) and blocked the CFA-induced decrease in ipsilateral paw withdrawal latency by 60% of the value in the saline-treated group (P=0.01). The number of formalin-induced flinches in the second phase in the group treated with MSOP and TBOA is increased by 56% (P=0.04) of the value in the TBOA-treated group. CFA-induced paw withdrawal latency in the group treated with MSOP and TBOA is decreased by 86% (P=0.03) of the value in the TBOA-treated group[2].

storage

Store at RT

MSOP Preparation Products And Raw materials

Raw materials

Preparation Products

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MSOP Suppliers

CHINA 30 Germany 2 Japan 1 United Kingdom 2 United States 10 USA 1 Global 46
EMMX Biotechnology LLC
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info@emmx.com
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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32435
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58
TargetMol Chemicals Inc.
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+1-781-999-5354;
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support@targetmol.com
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United States
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39035
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58
ApexBio Technology
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Abcam Limited
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us.orders@abcam.com
Country
United States
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50
United States Biological
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chemicals@usbio.net
Country
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MedChemExpress
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sales@medchemexpress.com
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Riedel-de Haen AG
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Sciencelab.com, Inc.
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Spectrum Chemicals & Laboratory Products
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66515-29-5, MSOPRelated Search:

ALPHA-METHYL-DL-SERINE MSOP

  • MSOP
  • (RS)-ALPHA-METHYLSERINE-O-PHOSPHATE
  • (R,S)-a-Methylserine-O-phosphate
  • (RS)-α-Methylserine-O-phosphate
  • Serine, 2-methyl-O-phosphono-
  • 2-Methyl-O- phosphonoserine
  • MSOP, group III metabotropic glutamate receptor antagonist
  • 66515-29-5
  • 66515-29-2
  • Glutamate receptor