6-[(phenylsulfanyl)methyl]-2-sulfanylpyrimidin-4-ol

Product Name: 6-[(phenylsulfanyl)methyl]-2-sulfanylpyrimidin-4-ol
CAS No.: 189057-68-9
Chemical Name: 6-[(phenylsulfanyl)methyl]-2-sulfanylpyrimidin-4-ol
Synonyms: ZINC05626394;ZINC05626394 >=98% (HPLC);6-[(phenylsulfanyl)methyl]-2-sulfanylpyrimidin-4-ol;4(1H)-Pyrimidinone, 2,3-dihydro-6-[(phenylthio)methyl]-2-thioxo-
CBNumber: CB24198516
Molecular Formula: C11H10N2OS2
Formula Weight: 250.34
MOL File: 189057-68-9.mol

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6-[(phenylsulfanyl)methyl]-2-sulfanylpyrimidin-4-ol Property

Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 25mg/mL, clear
pka: 7.32±0.20(Predicted)
form: powder
color: white to beige

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Oral

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1568
Product name: ZINC05626394
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $94.4
Updated: 2025/07/31

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6-[(phenylsulfanyl)methyl]-2-sulfanylpyrimidin-4-ol Chemical Properties,Usage,Production

Description

ZINC05626394 is a Cytochrome b5 reductase 3 (CYB5R3) inhibitor. It acts by increasing NO bioavailability.

Uses

ZINC05626394 is a cytochrome b5 reductase 3 inhibitor with activity by increasing nitric oxide bioavailability. ZINC05626394 may have potential applications in anti-cancer suppression, especially in combination with antibody drug conjugates (ADCs) and immune checkpoint inhibitors. The efficacy of ZINC05626394 may be limited by different mechanisms, including antigen-related resistance and failure of endocytosis[1].

References

[1] Mechanisms of Resistance to Antibody-Drug Conjugates DOI:10.1074/jbc.M114.629964

6-[(phenylsulfanyl)methyl]-2-sulfanylpyrimidin-4-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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6-[(phenylsulfanyl)methyl]-2-sulfanylpyrimidin-4-ol Suppliers

China 3 United Kingdom 1 United States 2 Global 6

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189057-68-9, 6-[(phenylsulfanyl)methyl]-2-sulfanylpyrimidin-4-olRelated Search:

ZINC13466751 6-hydroxy-3-methyl-5-(2-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)pyrimidine-2,4(1H,3H)-dione N-(2-(1H-indol-3-yl)ethyl)-2-((8-oxo-8H-benzo[c]indolo[3,2,1-ij][1,5]naphthyridin-12-yl)oxy)propanamide 3-Thiophenecarboxylic acid, 5-[[4-(carboxymethoxy)-3-methoxyphenyl]methylene]-2-[(4-ethoxyphenyl)amino]-4,5-dihydro-4-oxo-, 3-ethyl ester (5Z)-2-hydroxy-4-methyl-6-oxo-5-[(5-phenylfuran-2-yl)methylidene]-5,6-dihydropyridine-3-carbonitrile Benzamide, 4-[2-[1,5-dihydro-1-(4-nitrophenyl)-5-oxo-3-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]- N-(2-(1H-indol-3-yl)ethyl)-2-((8-oxo-8H-benzo[c]indolo[3,2,1-ij][1,5]naphthyridin-12-yl)oxy)acetamide ZINC03129319

6-[(phenylsulfanyl)methyl]-2-sulfanylpyrimidin-4-ol

ZINC05626394 >=98% (HPLC)

ZINC05626394

4(1H)-Pyrimidinone, 2,3-dihydro-6-[(phenylthio)methyl]-2-thioxo-

189057-68-9