ChemicalBook > CAS DataBase List > 2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE

2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE

Product Name: 2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE
CAS No.: 99368-67-9
Chemical Name: 2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE
Synonyms: C90145;2-Chloro-3-trifluoromethyl-5-nitropyridine;2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE;Pyridine, 2-chloro-5-nitro-3-(trifluoromethyl)-;2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE ISO 9001：2015 REACH
CBNumber: CB2421144
Molecular Formula: C6H2ClF3N2O2
Formula Weight: 226.54
MOL File: Mol file

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2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE Property

Boiling point:: 249℃
Density: 1.618
Flash point:: 105℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
pka: -6.04±0.10(Predicted)
Appearance: Light yellow to yellow Liquid
InChI: InChI=1S/C6H2ClF3N2O2/c7-5-4(6(8,9)10)1-3(2-11-5)12(13)14/h1-2H
InChIKey: OPEZLLCPUDLUFV-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C([N+]([O-])=O)C=C1C(F)(F)F

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Safety

RIDADR: 2810
HazardClass: 6.1
PackingGroup: Ⅲ
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: C596118
Product name: 2-Chloro-5-nitro-3-(trifluoromethyl)pyridine
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: C596118
Product name: 2-Chloro-5-nitro-3-(trifluoromethyl)pyridine
Packaging: 5g
Price: $145
Updated: 2021/12/16

ChemScene

Product number: CS-W019821
Product name: 2-Chloro-5-nitro-3-(trifluoromethyl)pyridine
Purity: 99.98%
Packaging: 25g
Price: $145
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC105704
Product name: 2-chloro-5-nitro-3-(trifluoromethyl)pyridine
Packaging: 5G
Price: $180
Updated: 2021/12/16

Apolloscientific

Product number: PC56251
Product name: 2-Chloro-5-nitro-3-(trifluoromethyl)pyridine
Purity: 97%
Packaging: 5g
Price: $82
Updated: 2021/12/16

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2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE Chemical Properties,Usage,Production

Synthesis

99368-66-8

99368-67-9

General procedure for the synthesis of 2-chloro-3-trifluoromethyl-5-nitropyridine from 2-hydroxy-5-nitro-3-trifluoromethylpyridine: Thionyl chloride (SOCl2, 18.45 mL, 253 mmol) was slowly added dropwise to a reaction vial containing 5-nitro-3-(trifluoromethyl)pyridin-2-ol (2.63 g, 12.64 mmol). Subsequently, N,N-dimethylformamide (DMF, 1.957 mL, 25.3 mmol) was added as a catalyst. The reaction mixture was stirred at 100°C for 10 hours. Upon completion of the reaction, the reaction solution was concentrated under reduced pressure to remove excess thionyl chloride. The concentrated residue was extracted by partitioning between ethyl acetate (EA) and saturated sodium bicarbonate (NaHCO3) solution. The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford the crude product 2-chloro-5-nitro-3-(trifluoromethyl)pyridine (2.46 g, 10.86 mmol, 86% yield), which could be used in the next reaction without further purification. Thin layer chromatography (TLC) analysis conditions: petroleum ether/ethyl acetate (PE/EA = 5:1), Rf = 0.6. 1H NMR (400 MHz, CDCl3) δ: 9.23-9.59 (m, 1H), 8.79 (d, J = 2.4 Hz, 1H).

References

[1] Patent: US2014/275111, 2014, A1. Location in patent: Paragraph 0259; 0260
[2] Patent: WO2014/141187, 2014, A1. Location in patent: Page/Page column 49; 59; 63; 87; 88; 124
[3] Patent: US2007/60623, 2007, A1. Location in patent: Page/Page column 39
[4] Patent: WO2016/37578, 2016, A1. Location in patent: Page/Page column 84
[5] Patent: WO2006/42289, 2006, A2. Location in patent: Page/Page column 52

2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Chloro-5-nitro-3-(trifluoroMethyl)pyridine 99368-67-9
Price: US $1.00-1.00/Kg/Drum
Min. Order: 1g
Purity: 98%
Supply Ability: 50tons
Release date: 2020-05-12

Dideu Industries Group Limited

Product: 2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE 99368-67-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-22

Career Henan Chemical Co

Product: 2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE 99368-67-9
Price: US $1.00/KG
Min. Order: 1G
Purity: 99%
Supply Ability: 100KG
Release date: 2018-08-13

99368-67-9, 2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINERelated Search:

2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE

C90145

2-Chloro-3-trifluoromethyl-5-nitropyridine

Pyridine, 2-chloro-5-nitro-3-(trifluoromethyl)-

2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE ISO 9001：2015 REACH

99368-67-9

C6H2ClF3N2O2