ChemicalBook > CAS DataBase List > 2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE

2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE

Product Name
2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE
CAS No.
99368-67-9
Chemical Name
2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE
Synonyms
C90145;2-Chloro-3-trifluoromethyl-5-nitropyridine;2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE;Pyridine, 2-chloro-5-nitro-3-(trifluoromethyl)-;2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE ISO 9001：2015 REACH
CBNumber
CB2421144
Molecular Formula
C6H2ClF3N2O2
Formula Weight
226.54
MOL File
Mol file
More
Less

2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE Property

Boiling point:
249℃
Density 
1.618
Flash point:
105℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
pka
-6.04±0.10(Predicted)
Appearance
Light yellow to yellow Liquid
InChI
InChI=1S/C6H2ClF3N2O2/c7-5-4(6(8,9)10)1-3(2-11-5)12(13)14/h1-2H
InChIKey
OPEZLLCPUDLUFV-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=C([N+]([O-])=O)C=C1C(F)(F)F
More
Less

Safety

RIDADR 
2810
HazardClass 
6.1
PackingGroup 
Ⅲ
HS Code 
2933399990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

More
Less

N-Bromosuccinimide Price

TRC
Product number
C596118
Product name
2-Chloro-5-nitro-3-(trifluoromethyl)pyridine
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
C596118
Product name
2-Chloro-5-nitro-3-(trifluoromethyl)pyridine
Packaging
5g
Price
$145
Updated
2021/12/16
ChemScene
Product number
CS-W019821
Product name
2-Chloro-5-nitro-3-(trifluoromethyl)pyridine
Purity
99.98%
Packaging
25g
Price
$145
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC105704
Product name
2-chloro-5-nitro-3-(trifluoromethyl)pyridine
Packaging
5G
Price
$180
Updated
2021/12/16
Apolloscientific
Product number
PC56251
Product name
2-Chloro-5-nitro-3-(trifluoromethyl)pyridine
Purity
97%
Packaging
5g
Price
$82
Updated
2021/12/16
More
Less

2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE Chemical Properties,Usage,Production

Synthesis

99368-66-8

99368-67-9

General procedure for the synthesis of 2-chloro-3-trifluoromethyl-5-nitropyridine from 2-hydroxy-5-nitro-3-trifluoromethylpyridine: Thionyl chloride (SOCl2, 18.45 mL, 253 mmol) was slowly added dropwise to a reaction vial containing 5-nitro-3-(trifluoromethyl)pyridin-2-ol (2.63 g, 12.64 mmol). Subsequently, N,N-dimethylformamide (DMF, 1.957 mL, 25.3 mmol) was added as a catalyst. The reaction mixture was stirred at 100°C for 10 hours. Upon completion of the reaction, the reaction solution was concentrated under reduced pressure to remove excess thionyl chloride. The concentrated residue was extracted by partitioning between ethyl acetate (EA) and saturated sodium bicarbonate (NaHCO3) solution. The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford the crude product 2-chloro-5-nitro-3-(trifluoromethyl)pyridine (2.46 g, 10.86 mmol, 86% yield), which could be used in the next reaction without further purification. Thin layer chromatography (TLC) analysis conditions: petroleum ether/ethyl acetate (PE/EA = 5:1), Rf = 0.6. 1H NMR (400 MHz, CDCl3) δ: 9.23-9.59 (m, 1H), 8.79 (d, J = 2.4 Hz, 1H).

References

[1] Patent: US2014/275111, 2014, A1. Location in patent: Paragraph 0259; 0260
[2] Patent: WO2014/141187, 2014, A1. Location in patent: Page/Page column 49; 59; 63; 87; 88; 124
[3] Patent: US2007/60623, 2007, A1. Location in patent: Page/Page column 39
[4] Patent: WO2016/37578, 2016, A1. Location in patent: Page/Page column 84
[5] Patent: WO2006/42289, 2006, A2. Location in patent: Page/Page column 52

2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE Suppliers

China 111 France 1 India 1 Ukraine 1 United Kingdom 3 United States 17 Global 134
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
More
Less

View Lastest Price from 2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Chloro-5-nitro-3-(trifluoroMethyl)pyridine 99368-67-9
Price
US $1.00-1.00/Kg/Drum
Min. Order
1g
Purity
98%
Supply Ability
50tons
Release date
2020-05-12
Dideu Industries Group Limited
Product
2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE 99368-67-9
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-22
Career Henan Chemical Co
Product
2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE 99368-67-9
Price
US $1.00/KG
Min. Order
1G
Purity
99%
Supply Ability
100KG
Release date
2018-08-13

99368-67-9, 2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINERelated Search:


  • 2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE
  • C90145
  • 2-Chloro-3-trifluoromethyl-5-nitropyridine
  • Pyridine, 2-chloro-5-nitro-3-(trifluoromethyl)-
  • 2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE ISO 9001：2015 REACH
  • 99368-67-9
  • C6H2ClF3N2O2