OM99-2
- Product Name
- OM99-2
- CAS No.
- 314266-76-7
- Chemical Name
- OM99-2
- Synonyms
- OM99-2;EVNL-PSI-AAEF;InSolution? OM99-2;InSolution OM99-2 - CAS 314266-76-7 - Calbiochem;GLU-VAL-ASN-(2R,4S,5S)-5-AMINO-*4-HYDROXY-2,7-DIMET;glu-val-asn-[(2r,4s,5s)-5-amino-4-hydroxy-2,7-dimethyloctanoyl]-ala-glu-phe;[2-AMINOBENZOYL-GLY1]-GALANIN FRAGMENT (1-10)-LYS(RETRO-M-NITRO-TYR) AMIDE HUMAN;H-GLU-VAL-ASN-[(2R,4S,5S)-5-AMINO-4-HYDROXY-2,7-DIMETHYL-OCTANOYL]-ALA-GLU-PHE-OH;Glu-Val-Asn-[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyloctanoyl]-Ala-Glu-Phe >93% (HPLC), solid;[2-aminobenzoyl-gly1]-galanin fragment (1-10)-lys(retro-m-nitro-tyr) amide, human trifluoroacetate salt
- CBNumber
- CB2421700
- Molecular Formula
- C41H64N8O14
- Formula Weight
- 892.99
- MOL File
- 314266-76-7.mol
OM99-2 Property
- Boiling point:
- 1346.5±65.0 °C(Predicted)
- Density
- 1.289±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- form
- solid
- pka
- 3.48±0.10(Predicted)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 496000
- Product name
- InSolution OM99-2 - CAS 314266-76-7 - Calbiochem
- Purity
- An eight residue peptidomimetic, tight binding transition-state analog inhibitor of human brain memapsin 2.
- Packaging
- 250μg
- Price
- $617
- Updated
- 2025/07/31
- Product number
- G8291
- Product name
- Glu-Val-Asn-[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyloctanoyl]-Ala-Glu-Phe
- Purity
- >93% (HPLC), solid
- Packaging
- 0.5mg
- Price
- $959
- Updated
- 2022/05/15
- Product number
- CCH0002987
- Product name
- GLU-VAL-ASN-[(2R,4S,5S)-5-AMINO-4-HYDROXY-2,7-DIMETHYLOCTANOYL]-ALA-GLU-PHE
- Purity
- 95.00%
- Packaging
- 0.5MG
- Price
- $1232.39
- Updated
- 2021/12/16
OM99-2 Chemical Properties,Usage,Production
Uses
OM99-2, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a Ki value of 9.58 nM[1]. OM99-2 is significantly advanced the development of BACE1 inhibitor[2]. OM99-2 has the potential for the research of the Alzheimer's disease[3].
Biological Activity
Cell permeable: no', 'Primary Target
human brain memapsin 2', 'Product does not compete with ATP.', 'Reversible: no', 'Target Ki: 1.6 nM against recombinant memapsin 2; 9.58 nM against recombinant pro-memapsin 2; 48 nM against cathepsin D
IC 50
BACE1
References
[1] Ghosh AK, et al. Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase). J Am Chem Soc. 2000;122(14):3522-3523. DOI:10.1021/ja000300g
[2] Zhao J, et al. Targeting Amyloidogenic Processing of APP in Alzheimer's Disease. Front Mol Neurosci. 2020;13:137. Published 2020 Aug 4. DOI:10.3389/fnmol.2020.00137
[3] Dash C, et al. Aspartic peptidase inhibitors: implications in drug development. Crit Rev Biochem Mol Biol. 2003;38(2):89-119. DOI:10.1080/713609213
[4] Park H, et al. Determination of the active site protonation state of beta-secretase from molecular dynamics simulation and docking experiment: implications for structure-based inhibitor design. J Am Chem Soc. 2003;125(52):16416-16422. DOI:10.1021/ja0304493
OM99-2 Preparation Products And Raw materials
Raw materials
Preparation Products
OM99-2 Suppliers
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